Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes

Kruse, Rikke; Vienberg, Sara G.; Vind, Birgitte F.; Andersen, Birgitte; Højlund, Kurt

doi:10.1007/s00125-017-4373-5

Cited by 64 publications

(70 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, circulating FGF21 and CHI3L1 correlated positively with fasting plasma glucose and HbA1c, but inversely with insulin sensitivity in the total study cohort. These findings are consistent with several other studies, which has demonstrated elevated circulating levels of FGF21 and CHI3L1 in patients T2D (Nielsen et al 2008;Chavez et al 2009;Cheng et al 2011;Kruse et al 2017). However, in contrast to our hypothesis, these alterations did not attenuate the exerciseinduced regulation of these myokines in the muscle or the circulation.…”

Section: Discussionsupporting

confidence: 91%

“…The role of FGF21 as a myokine was first suggested by experimental work showing increased muscle expression and release of FGF21 in Akt1 overexpressing mice (Izumiya et al 2008). This was supported by studies showing increased muscle expression and serum FGF21 levels in response to physiological concentrations of insulin in humans (Hojman et al 2009;Kruse et al 2017). However, as reported previously (Kjobsted et al 2016), serum insulin levels declined~50% immediately after exercise in our study, supporting that the increase in circulating FGF21 in response to acute exercise does not originate from skeletal muscle but rather from the liver, where it seems to be mediated by an elevated glucagon-to-insulin ratio (Hansen et al 2015a).…”

Section: Discussionsupporting

confidence: 90%

“…; Kruse et al. ). However, in contrast to our hypothesis, these alterations did not attenuate the exercise‐induced regulation of these myokines in the muscle or the circulation.…”

Section: Discussionmentioning

confidence: 98%

“…For most novel putative myokines, it remains to be established whether skeletal muscle is the major origin of the exercise-induced increase in circulating levels. Moreover, the circulating levels of IL-6, CHI3L1, and FGF21 and less consistently ANGPTL4 have been reported to be elevated in patients with T2D and other insulin resistant conditions in the resting, fasting state (Duncan et al 2003;Nielsen et al 2008;Chavez et al 2009;Cheng et al 2011;Kruse et al 2017;Tjeerdema et al 2014;Xu et al 2005). Together with the reported existence of exercise resistance in some cohorts of insulin resistant individuals, these observations suggest that the exercise-mediated regulation of these known and putative myokines may be altered in patients with T2D.…”

Section: Introductionmentioning

confidence: 84%

See 3 more Smart Citations

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

et al. 2018

Self Cite

View full text Add to dashboard Cite

Regular exercise plays an important role in the prevention and treatment of type 2 diabetes (T2D). The synthesis and secretion of myokines in response to contraction may contribute to the beneficial metabolic effects of exercise. However, some exercise‐induced responses may be attenuated in T2D. Here, we investigated whether the effect of acute exercise on selected myokines are impaired in T2D. Skeletal muscle biopsies and blood samples were obtained from 13 men with T2D and 14 weight‐matched, glucose‐tolerant men before, immediately after and 3‐h after acute exercise (60 min cycling) to examine muscle expression and plasma/serum levels of selected myokines. One‐hour of exercise increased muscle expression of IL6, FGF21, ANGPTL4, CHI3L1, CTGF and CYR61, of which FGF21, ANGPTL4 and CHI3L1 increased further 3‐h into recovery, whereas expression of IL6, CYR61, and CTGF returned to baseline levels. There was no immediate effect of exercise on IL15 expression, but it decreased 3‐h into recovery. Plasma IL‐6 increased robustly, whereas circulating levels of FGF21, ANGPTL4, IL‐15, and CHI3L1 increased only modestly in response to exercise. All returned toward baseline levels 3‐h into recovery except for plasma ANGPTL4, which increased further. No significant differences in these responses to exercise were observed between the groups. Our results demonstrate that muscle expression and circulating levels of selected known and putative myokines were equally regulated by acute exercise in patients with T2D and weight‐matched controls. This suggests that the potential beneficial metabolic effects of these myokines are not impaired in patients with T2D.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

“…; Kruse et al. ). However, in contrast to our hypothesis, these alterations did not attenuate the exercise‐induced regulation of these myokines in the muscle or the circulation.…”

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 84%

See 2 more Smart Citations

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…The NCOA1 gene in adipocytes has also been shown to be associated with metabolic disease [87][88][89]. The KSR2 gene [60,90,91] and FGF21 [92][93][94] are also integrated genes in the network associated with obesity, Figure 7 and S3. Therefore, a number of the genes and pathways identified in Figure 7 and S3 provide potential therapeutic targets for adipocytes associated with obesity and metabolic disease.…”

Section: Discussionmentioning

confidence: 95%

Adipocyte epigenetic alterations and potential therapeutic targets in transgenerationally inherited lean and obese phenotypes following ancestral exposures

et al. 2019

View full text Add to dashboard Cite

The incidence of obesity has increased dramatically over the past two decades with a prevalence of approximately 40% of the adult population within the United States. The current study examines the potential for transgenerational adipocyte (fat cell) epigenetic alterations. Adipocytes were isolated from the gonadal fat pad of the great-grand offspring F3 generation 1-year old rats ancestrally exposed to DDT (dichlorodiphenyltrichloroethane), atrazine, or vehicle control in order to obtain adipocytes for DNA methylation analysis. Observations indicate that there were differential DNA methylated regions (DMRs) in the adipocytes with the lean or obese phenotypes compared to control normal (non-obese or lean) populations. The comparison of epigenetic alterations indicated that there were substantial overlaps between the different treatment lineage groups for both the lean and obese phenotypes. Novel correlated genes and gene pathways associated with DNA methylation were identified, and may aid in the discovery of potential therapeutic targets for metabolic diseases such as obesity. Observations indicate that ancestral exposures during critical windows of development can induce the epigenetic transgenerational inheritance of DNA methylation changes in adipocytes that ultimately may contribute to an altered metabolic phenotype. ARTICLE HISTORY

show abstract

The Next Generation Fecal Microbiota Transplantation: To Transplant Bacteria or Virome

Yu,

Wang,

Zhang

2023

Advanced Science

View full text Add to dashboard Cite

Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach for dysbiosis‐related diseases. However, the clinical practice of crude fecal transplants presents limitations in terms of acceptability and reproductivity. Consequently, two alternative solutions to FMT are developed: transplanting bacteria communities or virome. Advanced methods for transplanting bacteria mainly include washed microbiota transplantation and bacteria spores treatment. Transplanting the virome is also explored, with the development of fecal virome transplantation, which involves filtering the virome from feces. These approaches provide more palatable options for patients and healthcare providers while minimizing research heterogeneity. In general, the evolution of the next generation of FMT in global trends is fecal microbiota components transplantation which mainly focuses on transplanting bacteria or virome.

show abstract

Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes

Cited by 64 publications

References 50 publications

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

Adipocyte epigenetic alterations and potential therapeutic targets in transgenerationally inherited lean and obese phenotypes following ancestral exposures

The Next Generation Fecal Microbiota Transplantation: To Transplant Bacteria or Virome

Contact Info

Product

Resources

About