Effects of induced premaxillary suture fusion on the craniofacial morphology in growing rats

Ruan, Wen hua; Winger, Julia N.; Yu, Jack C.; Borke, James L.

doi:10.1016/j.archoralbio.2007.07.002

Cited by 6 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the Fgfr3 P244R mutant, we found that in animals with shortened or twisted snouts the premaxillary sutures lacked interdigitation and that snout deviation correlated with the presence of ipsilateral fusion of this suture. That premaxillary suture fusions can lead to skewing and shortening of the snout has been demonstrated in a rat model (Ruan et al,2008), and loss of extensive interdigitation has been correlated with lack of growth in the frontonasal suture (Nelson and Williams,2004). Additional fusions of the zygomatic arch bones, which develop through membranous ossification, were also present in Fgfr3 P244R mice.…”

Section: Discussionmentioning

confidence: 99%

Skeletal analysis of the Fgfr3^P244R mouse, a genetic model for the Muenke craniosynostosis syndrome

Twigg

Healy

Babbs

et al. 2009

Developmental Dynamics

View full text Add to dashboard Cite

Muenke syndrome, defined by heterozygosity for a Pro250Arg substitution in fibroblast growth factor receptor 3 (FGFR3), is the most common genetic cause of craniosynostosis in humans. We have used gene targeting to introduce the Muenke syndrome mutation (equivalent to P244R) into the murine Fgfr3 gene. A rounded skull and shortened snout (often skewed) with dental malocclusion was observed in a minority of heterozygotes and many homozygotes. Development of this incompletely penetrant skull phenotype was dependent on genetic background and sex, with males more often affected. However, these cranial abnormalities were rarely attributable to craniosynostosis, which was only present in 2/364 mutants; more commonly, we found fusion of the premaxillary and/or zygomatic sutures. We also found decreased cortical thickness and bone mineral densities in long bones. We conclude that although both cranial and long bone development is variably affected by the murine Fgfr3 P244R mutation, coronal craniosynostosis is not reliably reproduced. Developmental Dynamics 238:331-342, 2009.

show abstract

Section: Discussionmentioning

confidence: 99%

Skeletal analysis of the Fgfr3^P244R mouse, a genetic model for the Muenke craniosynostosis syndrome

Twigg

Healy

Babbs

et al. 2009

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the postnatal influence of the nasal septum potentially extends beyond the facial skeleton proper affecting the spatial relationship between the facial skeleton and neurocranium. Experimentally induced facial suture synostosis coupled with continued growth of the nasal septum results in changes in cranial base flexion (Rönning and Kantomaa, 1985), anterior cranial base length (Ruan et al, 2008) and the orientation of the facial skeleton relative to the cranial base and neurocranium (Rönning and Kantomaa, 1985;Mooney et al, 1992;Holton et al, 2010). Thus, relative differences in nasal septal and facial growth potentially explain part of the variation in cranial base angulation due to facial size differences between modern and premodern hominins (i.e., facial packing; e.g., Lieberman et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Holton

Franciscus

Marshall

et al. 2010

The Anatomical Record

View full text Add to dashboard Cite

The influence of the chondrocranium in craniofacial development and its role in the reduction of facial size and projection in the genus Homo is incompletely understood. As one component of the chondrocranium, the nasal septum has been argued to play a significant role in human midfacial growth, particularly with respect to its interaction with the premaxilla during prenatal and early postnatal development. Thus, understanding the precise role of nasal septal growth on the facial skeleton is potentially informative with respect to the evolutionary change in craniofacial form. In this study, we assessed the integrative effects of the nasal septum and premaxilla by experimentally reducing facial length in Sus scrofa via circummaxillary suture fixation. Following from the nasal septal-traction model, we tested the following hypotheses: (1) facial growth restriction produces no change in nasal septum length; and (2) restriction of facial length produces compensatory premaxillary growth due to continued nasal septal growth. With respect to hypothesis 1, we found no significant differences in septum length (using the vomer as a proxy) in our experimental (n ¼ 10), control (n ¼ 9) and surgical sham (n ¼ 9) trial groups. With respect to hypothesis 2, the experimental group exhibited a significant increase in premaxilla length. Our hypotheses were further supported by multivariate geometric morphometric analysis and support an integrative relationship between the nasal septum and premaxilla. Thus, continued assessment of the growth and integration of the nasal septum and premaxilla is potentially informative regarding the complex developmental mechanisms that underlie facial reduction in genus Homo evolution. Anat Rec, 294:68-78, 2011. V V C 2010 Wiley-Liss, Inc.

show abstract

“…It is also interesting to note that premature synostosis of the premaxillary suture in animal models can affect other aspects of facial form such as anterior cranial base morphology (Mooney et al. 1992; Ruan et al. 2008).…”

Section: Discussionmentioning

confidence: 99%

Sutural growth restriction and modern human facial evolution: an experimental study in a pig model

et al. 2009

View full text Add to dashboard Cite

Facial size reduction and facial retraction are key features that distinguish modern humans from archaic Homo. In order to more fully understand the emergence of modern human craniofacial form, it is necessary to understand the underlying evolutionary basis for these defining characteristics. Although it is well established that the cranial base exerts considerable influence on the evolutionary and ontogenetic development of facial form, less emphasis has been placed on developmental factors intrinsic to the facial skeleton proper. The present analysis was designed to assess anteroposterior facial reduction in a pig model and to examine the potential role that this dynamic has played in the evolution of modern human facial form. Ten female sibship cohorts, each consisting of three individuals, were allocated to one of three groups. In the experimental group (n = 10), microplates were affixed bilaterally across the zygomaticomaxillary and frontonasomaxillary sutures at 2 months of age. The sham group (n = 10) received only screw implantation and the controls (n = 10) underwent no surgery. Following 4 months of post-surgical growth, we assessed variation in facial form using linear measurements and principal components analysis of Procrustes scaled landmarks. There were no differences between the control and sham groups; however, the experimental group exhibited a highly significant reduction in facial projection and overall size. These changes were associated with significant differences in the infraorbital region of the experimental group including the presence of an infraorbital depression and an inferiorly and coronally oriented infraorbital plane in contrast to a flat, superiorly and sagittally infraorbital plane in the control and sham groups. These altered configurations are markedly similar to important additional facial features that differentiate modern humans from archaic Homo, and suggest that facial length restriction via rigid plate fixation is a potentially useful model to assess the developmental factors that underlie changing patterns in craniofacial form associated with the emergence of modern humans.

show abstract

Effects of induced premaxillary suture fusion on the craniofacial morphology in growing rats

Cited by 6 publications

References 25 publications

Skeletal analysis of the Fgfr3^P244R mouse, a genetic model for the Muenke craniosynostosis syndrome

Skeletal analysis of the Fgfr3^P244R mouse, a genetic model for the Muenke craniosynostosis syndrome

Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Sutural growth restriction and modern human facial evolution: an experimental study in a pig model

Contact Info

Product

Resources

About

Effects of induced premaxillary suture fusion on the craniofacial morphology in growing rats

Cited by 6 publications

References 25 publications

Skeletal analysis of the Fgfr3P244R mouse, a genetic model for the Muenke craniosynostosis syndrome

Skeletal analysis of the Fgfr3P244R mouse, a genetic model for the Muenke craniosynostosis syndrome

Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Sutural growth restriction and modern human facial evolution: an experimental study in a pig model

Contact Info

Product

Resources

About

Skeletal analysis of the Fgfr3^P244R mouse, a genetic model for the Muenke craniosynostosis syndrome

Skeletal analysis of the Fgfr3^P244R mouse, a genetic model for the Muenke craniosynostosis syndrome