Effects of increasing durations of immobilization stress on plasma corticosterone level, learning and memory and hippocampal BDNF gene expression in rats

Nooshinfar, Elaheh; Akbarzadeh-Baghban, Alireza; Meisami, Esmail

doi:10.1016/j.neulet.2011.05.243

Cited by 16 publications

(13 citation statements)

References 30 publications

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“…Further, the behavioral effects on memory of stressors when assayed in the PA test depend on the severity, duration of the stress, and the stage of the animal within the sexual cycle. In male rats, long‐term restraint stress increased memory impairments as assayed in the PA test, which was an effect associated with decreases in hippocampal BDNF gene expression (Nooshinfar et al., 2011). Interestingly, BDNF expression in the hippocampus has been shown to be inhibited by corticosterone (Schaaf et al., 2000).…”

Section: Discussionmentioning

confidence: 99%

Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Khaleghi

Rajizadeh

Bashiri³

et al. 2021

Brain and Behavior

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Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. Methods In this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress‐induced impairments in cognitive‐behaviors. Adult female Wistar rats at 21–22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MWM) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety‐like behaviors. Results In sham and OVX rats, both physical and psychological stressors were associated with an increase in EPM‐determined anxiety‐like behavior. OVX rats exhibited decreased explorative behavior in comparison with nonstressed sham rats (p < .05). Both physical stress and psychological stress resulted in disrupted spatial cognition as assayed in the MWM (p < .05) and impaired learning and memory as determined by the PA test when the OVX and sham groups were compared with the nonstressed sham group. Estrogen increased explorative behavior, learning and memory (p < .05), and decreased anxiety‐like behavior compared with vehicle in OVX rats exposed to either type of stressor. Conclusions When taken together, estrogen and both stressors had opposite effects on memory, anxiety, and PA performance in a rat model of menopause, which has important implications for potential protective effects of estrogen in postmenopausal women exposed to chronic stress.

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Section: Discussionmentioning

confidence: 99%

Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Khaleghi

Rajizadeh

Bashiri³

et al. 2021

Brain and Behavior

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“…Several studies have demonstrated that the stress may cause increase in blood corticosterone level [ 21 , 22 , 23 ], this may cause increase in blood glucose level to meet energy demand during stress. Magariños et al [ 24 ] demonstrated that, the stress-induced rise in plasma glucose may be attributed to corticosterone mediated enhanced metabolism to meet the increased demands of the body organs during stress.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model

Sharma

Sim

Park

et al. 2015

Korean J Physiol Pharmacol

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Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice were once enforced into immobilization stress for 30 min and returned to the cage. The blood glucose level was measured 30, 60, and 120 min after immobilization stress initiation. We found that intracerebroventricular (i.c.v.) injection with 30 µg of glyburide, glipizide, glimepiride or tolazamide attenuated the increased blood glucose level induced by immobilization stress. Immobilization stress causes an elevation of the blood corticosterone and insulin levels. Sulfonylureas pretreated i.c.v. caused a further elevation of the blood corticosterone level when mice were forced into the stress. In addition, sulfonylureas pretreated i.c.v. alone caused an elevation of the plasma insulin level. Furthermore, immobilization stress-induced insulin level was reduced by i.c.v. pretreated sulfonylureas. Our results suggest that lowering effect of sulfonylureas administered supraspinally against immobilization stress-induced increase of the blood glucose level appears to be primarily mediated via elevation of the plasma insulin level.

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“…Taken together, we believe that the BDNF up-regulation identified in the GR DBHCre female mutants is a secondary effect to which the increased depressive-like behavior of these animals cannot be attributed. Other authors have demonstrated that short-term stress can cause an increase in BDNF levels in the hippocampus and PFC, and this finding was suggested to represent a compensatory effect (Marmigere et al, 2003, Fanous et al, 2010, Nooshinfar et al, 2011. Similarly, increased BDNF levels observed in the GR DBHCre females could be compensatory for the mutation-related impairments for which changes in other systems are primary mechanisms or be unrelated to observed phenotype.…”

Section: Accepted Manuscriptmentioning

confidence: 90%

Disruption of glucocorticoid receptors in the noradrenergic system leads to BDNF up-regulation and altered serotonergic transmission associated with a depressive-like phenotype in female GRDBHCre mice

Chmielarz

Kreiner

Kot

et al. 2015

Pharmacology Biochemistry and Behavior

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Effects of increasing durations of immobilization stress on plasma corticosterone level, learning and memory and hippocampal BDNF gene expression in rats

Cited by 16 publications

References 30 publications

Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model

Disruption of glucocorticoid receptors in the noradrenergic system leads to BDNF up-regulation and altered serotonergic transmission associated with a depressive-like phenotype in female GRDBHCre mice

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