Effects of<i>Pistacia atlantica</i>on Oxidative Stress Markers and Antioxidant Enzymes Expression in Diabetic Rats

Bagheri, Shahrokh; Sarabi, Mostafa Moradi; Khosravi, Peyman; Khorramabadi, Reza Mohammadrezaei; Veiskarami, Saeid; Ahmadvand, Hassan; Keshvari, Mahrokh

doi:10.1080/07315724.2018.1482577

Cited by 21 publications

(24 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress plays a central role in the development of many diseases such as cancer, diabetes, coronary heart disease and inflammation. Since, prescribing antioxidants is a beneficial way to prevent the progression of such diseases [8]. Hence, the aim of present study was to evaluate total antioxidant capacity of Z. nummularia, C. pontica and S. striata using FRAP assay.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the widespread use of chemical drugs, medicinal plants still play an important role in the production of drugs in the pharmaceutical industry [7]. The presence of bioactive compounds in medicinal plants causes the numerous biological effects such as antioxidant properties [8,9]. Natural antioxidants derived from medicinal plants are composed of polyphenols (including phenolic acids and flavonoids), carotenoids and vitamins [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Dokhani

Nazer²,

skokri³

et al. 2022

Egyptian Journal of Veterinary Sciences

View full text Add to dashboard Cite

R ESEARCHERS have shown an increasing attention to the use of medicinal plants because of their beneficial effect on human health. The antioxidant properties of medicinal plants is a strong reason to use them in the food and pharmaceutical industries. Hence, the aim of this study was to evaluate the antioxidant properties of Ziziphus nummularia, Crataegus pontica and Scrophularia striata. Aerial parts of Ziziphus nummularia, Crataegus pontica and Scrophularia striata were dried and ground. Then, plant samples were prepared using homogenizing plant powders in methanol solution. Finally, the total antioxidant capacity of the plants was assessed by ferric iron reducing antioxidant power (FRAP) assay.The results indicated that the total antioxidant capacity was found as 3.16, 2.95 and 1.14 mmol Fe 2+ /L for Ziziphus nummularia, Crataegus pontica and Scrophularia striata, respectively. According to our results, Ziziphus nummularia, Crataegus pontica and Scrophularia striata showed a potent antioxidant activity. It is recommended that utilization of Ziziphus nummularia, Crataegus pontica and Scrophularia striata in food and pharmaceutical industries could possibly possess beneficial health effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Dokhani

Nazer²,

skokri³

et al. 2022

Egyptian Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Daily nut consumption can improve dysmetabolic conditions such as obesity, type 2 diabetes, and related cardiovascular diseases [17,18]. In particular, Pistacia atlantica oleoresin has been proposed as an agent that protects the body against conditions associated with oxidative stress [19], including memory impairment, in lipopolysaccharide-treated rats [20]. Nevertheless, the potential beneficial impact of nut intake on neurodegenerative disorders, as well as on other cognitive-behavioral deficits, has been poorly explored.Compared to other nuts, pistachios possess a healthier nutritional profile, with low-fat content, high content of polyunsaturated fatty acids (13.3 g/100 g) and mono-unsaturated fatty acids (24.5 g/100 g), minerals (potassium, phosphorus, magnesium, and calcium) and vitamins (vitamin A, vitamin E, vitamin C, and vitamins B).…”

mentioning

confidence: 99%

Regular Intake of Pistachio Mitigates the Deleterious Effects of a High Fat-Diet in the Brain of Obese Mice

et al. 2020

View full text Add to dashboard Cite

Obesity has been associated with neurodegeneration and cognitive dysfunctions. Recent data showed that pistachio consumption is able to prevent and ameliorate dyslipidemia, hepatic steatosis, systemic and adipose tissue inflammation in mice fed a high-fat diet (HFD). The present study investigated the neuroprotective effects of pistachio intake in HFD mice. Three groups of mice were fed a standard diet (STD), HFD, or HFD supplemented with pistachio (HFD-P) for 16 weeks. Metabolic parameters (oxidative stress, apoptosis, and mitochondrial dysfunction) were analyzed by using specific assays and biomarkers. The pistachio diet significantly reduced the serum levels of triglycerides and cholesterol in the HFD model. No difference was observed in the index of insulin resistance between HFD and HFD-P. A higher number of fragmented nuclei were found in HFD cerebral cortex compared to STD and HFD-P. A decrease in reactive oxygen species, singlet oxygen and phosphorylated extracellular signal-regulated kinase, and an increase of superoxide dismutase 2 and heme oxygenase expression were found in the brains of the HFD-P samples compared to HFD. Furthermore, the impaired mitochondrial function found in HFD brain was partially recovered in HFD-P mice. These results suggest that the regular intake of pistachio may be useful in preventing obesity-related neurodegeneration, being able to reduce both metabolic and cellular dysfunctions.The positive effects of the Mediterranean diet on health have been well documented [9,10]. The longevity of one Mediterranean population, over 90 years old without dementia, was attributed to the nutraceutical components of the Mediterranean diet [11]. Functional food has been reported to delay or inhibit neurodegeneration, suggesting their employment as an alternative therapeutic strategy for correlated diseases [12][13][14].Benefits of nut consumption (mainly pistachios, walnuts, and almonds) have been described in studies on both animals and humans [15,16]. Daily nut consumption can improve dysmetabolic conditions such as obesity, type 2 diabetes, and related cardiovascular diseases [17,18]. In particular, Pistacia atlantica oleoresin has been proposed as an agent that protects the body against conditions associated with oxidative stress [19], including memory impairment, in lipopolysaccharide-treated rats [20]. Nevertheless, the potential beneficial impact of nut intake on neurodegenerative disorders, as well as on other cognitive-behavioral deficits, has been poorly explored.Compared to other nuts, pistachios possess a healthier nutritional profile, with low-fat content, high content of polyunsaturated fatty acids (13.3 g/100 g) and mono-unsaturated fatty acids (24.5 g/100 g), minerals (potassium, phosphorus, magnesium, and calcium) and vitamins (vitamin A, vitamin E, vitamin C, and vitamins B). Phytochemicals of pistachio show high bioavailability, contributing to the beneficial relationship between pistachio consumption and health-related outcomes [21]. Furthermore, recent data have demonstra...

show abstract

“…Pistachios contain polyphenols that act as radical scavengers, neutralising reactive oxygen species (ROS) and enhancing endogenous antioxidant defences. Many studies have demonstrated the antioxidant activity of extracts obtained from different pistachio parts in both in vitro [ 97 , 98 , 99 , 100 , 101 ] and in vivo models, such as in animals [ 64 , 97 , 99 , 102 , 103 , 104 , 105 , 106 , 107 , 108 ] and humans [ 7 , 15 , 54 , 55 , 76 , 109 ]. Therefore, antioxidants present in pistachios could have significant effects on the regulation of oxidative stress and a reduced risk of chronic diseases.…”

Section: Health Benefits Of Pistachio Consumptionmentioning

confidence: 99%

Why Should Pistachio Be a Regular Food in Our Diet?

et al. 2022

View full text Add to dashboard Cite

The pistachio is regarded as a relevant source of biologically active components that, compared to other nuts, possess a healthier nutritional profile with low-fat content composed mainly of monounsaturated fatty acids, a high source of vegetable protein and dietary fibre, remarkable content of minerals, especially potassium, and an excellent source of vitamins, such as vitamins C and E. A rich composition in terms of phytochemicals, such as tocopherols, carotenoids, and, importantly, phenolic compounds, makes pistachio a powerful food to explore its involvement in the prevention of prevalent pathologies. Although pistachio has been less explored than other nuts (walnut, almonds, hazelnut, etc.), many studies provide evidence of its beneficial effects on CVD risk factors beyond the lipid-lowering effect. The present review gathers recent data regarding the most beneficial effects of pistachio on lipid and glucose homeostasis, endothelial function, oxidative stress, and inflammation that essentially convey a protective/preventive effect on the onset of pathological conditions, such as obesity, type 2 diabetes, CVD, and cancer. Likewise, the influence of pistachio consumption on gut microbiota is reviewed with promising results. However, population nut consumption does not meet current intake recommendations due to the extended belief that they are fattening products, their high cost, or teething problems, among the most critical barriers, which would be solved with more research and information.

show abstract

Effects ofPistacia atlanticaon Oxidative Stress Markers and Antioxidant Enzymes Expression in Diabetic Rats

Cited by 21 publications

References 34 publications

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Regular Intake of Pistachio Mitigates the Deleterious Effects of a High Fat-Diet in the Brain of Obese Mice

Why Should Pistachio Be a Regular Food in Our Diet?

Contact Info

Product

Resources

About