Effects of Ginkgo biloba on Early Decompression after Spinal Cord Injury

Abstract

Spinal cord injury (SCI) is a severe trauma of the central nervous system characterized by high disability and high mortality. Clinical progress has been achieved in understanding the pathological mechanism of SCI and its early treatment, but the results are unsatisfactory. In China, increasing attention has been paid to the role of traditional Chinese medicine in the treatment of SCI. In particular, extracts from the leaves of Ginkgo biloba (maidenhair tree), which have been reported to exert anti-inflammatory and antioxidant properties and repair a variety of active cellular damage, have been applied therapeutically for centuries. In this study, we established a rat SCI model to investigate the effects of Ginkgo biloba leaves on decompression at different stages of SCI. The application of Ginkgo biloba leaves during the decompression of SCI at different time points, the neurological recovery of SCI, and the underlying molecular mechanism were explored. The findings provide reliable experimental data that reveal the mechanism of GBI (Ginkgo biloba injection) in the clinical treatment of SCI.

Ginkgo biloba repair spinal cord ischemia reperfusion injury in rats by regulating Ferroptosis signaling pathway

“…The occurrence of SCIRI is di cult to avoid in many cases, and once it occurs, the prognosis is poor and the quality of life of patients is greatly affected, so the treatment after the occurrence is a challenge. GBE has the antioxidant effect of inhibiting ferroptosis, and it has been proved by experiments that GBE can promote the recovery of nerve function in rats with SCI 14 . However, the relationship between GBE and ferroptosis during SCIRI remains unclear.…”

“…At the same time, due to the emergence of ferroptosis, a new form of cell death, some scholars interested in ferroptosis have con rmed that GB can inhibit ferroptosis 13 . As early as 2020, Guo et al 's research results showed that GB can further reduce the in ammatory response after decompression of spinal cord injury, and play a role in protecting neurons and repairing spinal cord injury 14 . However, the exact mechanism of action of GBE in the treatment of SCIRI remains unclear.…”

Design of Mixed Medicinal Plants, Rich in Polyphenols, Vitamins B, and Palmitoylethanolamide-Based Supplement to Help Reduce Nerve Pain: A Preclinical Study

“…Gingko Biloba has been demonstrated to attenuate mechanical and cold allodynia in a rat model of neuropathic pain, suggesting its use in managing neuropathic pain in humans [24]. In addition, other studies explored the effects of Gingko biloba on spinal cord neuron deterioration in several studies in vivo [25,26]. Finally, it is known to have effects on neuronal plasticity [27], leading to neuroprotection through anti-apoptotic activity [28] that, combined with its antioxidant effect [29,30], improved nerve repair.…”