Effects of <i>Bifidobacterium lactis</i> HN019 and Prebiotic Oligosaccharide Added to Milk on Iron Status, Anemia, and Growth Among Children 1 to 4 Years Old

Sazawal, Sunil; Dhingra, Usha; Hiremath, Girish; Sarkar, Archana; Dhingra, Pratibha; Dutta, Arup; Menon, Venugopal P.; Black, Robert E.

doi:10.1097/mpg.0b013e3181d98e45

Cited by 63 publications

(111 citation statements)

References 42 publications

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“…This is especially true for the group of B vitamins [85,86]. Furthermore, pro-and prebiotics can promote absorption of minerals like magnesium, iron, and calcium [87][88][89]. This may be due to increased SCFA production, which decreases intestinal pH and promotes epithelial health leading to increased mineral solubility and uptake [90].…”

Section: Pre- Pro- and Antibioticsmentioning

confidence: 99%

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

Fluitman

Clercq

Keijser

et al. 2017

Expert Review of Endocrinology & Metabolism

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Introduction: Malnutrition refers to both over-and undernutrition and results from a disruption in energy balance. It affects one in three people worldwide and is associated with increased morbidity and mortality. The intestinal microbiota represents a newly identified factor that might contribute to the development of malnutrition, as it harbors traits that complement the human metabolic and endocrine capabilities, thereby influencing energy balance. Areas covered: In the current review, we aim to give a comprehensive overview on the microbiota, its development and its possible influence on energy balance, with emphasis the role of short-chain fatty acids. We also consider microbial characteristics associated with obesity and undernutrition and evaluate microbial manipulating strategies. The PubMed database was searched using the terms:

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Section: Pre- Pro- and Antibioticsmentioning

confidence: 99%

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

Fluitman

Clercq

Keijser

et al. 2017

Expert Review of Endocrinology & Metabolism

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“…There is also some evidence that probiotic can enhance bioavailability of iron. Human studies have been performed to discover underlying mechanism of probiotic effect on iron status, such as creating an acidic environment in the intestinal tract which makes iron more absorbable, making iron biologically available by producing iron-chelating ligands, or degrading mineral complexing phytic acid from food [13][14][15]. Therefore, making probiotics a part of a diet plan, can prevent and ameliorate iron deficiency anemia in humans.…”

Section: Introductionmentioning

confidence: 99%

Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia

Korcok¹,

Tršić-Milanović²,

Ivanović

et al. 2018

Chem. Pharm. Bull.

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Probiotics are increasingly more present both as functional foods, and in pharmaceutical preparations with multiple levels of action that contribute to human health. Probiotics realize their positive effects with a proper dose, and by maintaining a declared number of probiotics cells by the expiration date. Important precondition for developing a probiotic product is the right choice of clinically proven probiotic strain, the choice of other active components, as well as, the optimization of the quantity of active component of probiotic per product dose. Optimal quantity of active component L. plantarum of 50 mg, was selected. The purpose of this scientific paper is to select the optimal formulation of probiotic culture in a dietary supplement that contains iron and vitamin C, and to also determine its expiration date by the analysis of the number of viable probiotic cells.

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“…Many Bifidobacterium species are not inhibited by the bacteriostatic properties of lactoferrin, and the growth of some is actually enhanced in the presence of lactoferrin (Kim et al 2004). A recent study has shown that the addition of Bifidobacterium species to milk as a probiotic decreases the incidence of iron deficiency in young children (Sazawal et al 2010). Although the mechanism for this effect is unknown, it was suggested that the use of probiotics could reduce enteric infections resulting in better iron absorption.…”

Section: Iron Absorption During Sucklingmentioning

confidence: 97%

Intestinal iron absorption during suckling in mammals

2011

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The maintenance of appropriate iron levels is important for mammalian health, particularly during the rapid growth period following birth. Too little iron can lead to irreversible damage to the developing central nervous system and too much iron at this point can have adverse long term consequences, possibly due to excessive free radical production. In order to maintain iron levels, intestinal iron absorption is very efficient in young mammals, such that almost all of the iron in breast milk is utilized. However this high level of absorption is unable to be down regulated in response to excess iron as it can be in adults, implying that different regulatory processes are involved during suckling. Various mechanisms have been proposed to explain this high absorption, including enhanced expression of the proteins involved in iron absorption in adults (particularly DMT1 and ferroportin), non-specific uptake via pinocytosis, and the uptake of lactoferrin bound iron by the lactoferrin receptor. However, at present the precise mechanism is unclear. It is possible that all of these components contribute to the high intestinal iron absorption seen during suckling, or a novel, as yet undescribed, mechanism could be involved. This review summarises the evidence for and against each of the mechanisms described above and highlights how little is known about iron homeostasis in this vital stage of development.

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Effects of Bifidobacterium lactis HN019 and Prebiotic Oligosaccharide Added to Milk on Iron Status, Anemia, and Growth Among Children 1 to 4 Years Old

Abstract: Preschoolers are usually fed milk, which has good acceptance and can be easily fortified for delivery of probiotics. Consumption of B lactis HN019 and prebiotic-fortified milk resulted in a smaller number of iron-deficient preschoolers and increased weight gain.

Cited by 63 publications

References 42 publications

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia

Intestinal iron absorption during suckling in mammals

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