2017
DOI: 10.1080/00207454.2017.1396986
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Abstract: Higher BMI and creatinine clearance are protective regarding cognitive and functional decline for women, whereas higher cognitive reserve may lead to faster decline in instrumental functionality. APOE haplotypes affected the age at AD onset, but not cognitive or functional decline.

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Cited by 8 publications
(3 citation statements)
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“…The research on cardiovascular patients shows that when patients have glucose metabolism abnormalities, their MMSE score is 0.4 lower than that of normal patients. With the increase of blood glucose concentration, the branches decrease continuously, and there is a negative correlation between them (Oliveira et al, 2018). In the MMSE test of 182 elderly people, it was found that the MMSE score of 3% patients with impaired fasting glucose tolerance was greater than 28.3, and the probability ratio of cognitive impairment of the patients reached 9.08 (Dubois et al, 2018).…”
Section: Discussionmentioning
confidence: 98%
“…The research on cardiovascular patients shows that when patients have glucose metabolism abnormalities, their MMSE score is 0.4 lower than that of normal patients. With the increase of blood glucose concentration, the branches decrease continuously, and there is a negative correlation between them (Oliveira et al, 2018). In the MMSE test of 182 elderly people, it was found that the MMSE score of 3% patients with impaired fasting glucose tolerance was greater than 28.3, and the probability ratio of cognitive impairment of the patients reached 9.08 (Dubois et al, 2018).…”
Section: Discussionmentioning
confidence: 98%
“…The research on cardiovascular patients shows that when patients have glucose metabolism abnormalities, their MMSE score is 0.4 lower than that of normal patients. With the increase of blood glucose concentration, the branches decrease continuously, and there is a negative correlation between them (Oliveira et al, 2018). In the MMSE test of 182 elderly people, it was found that the MMSE score of 3% patients with impaired fasting glucose tolerance was greater than 28.3, and the probability ratio of cognitive impairment of the patients reached 9.08 (Dubois et al, 2018).…”
Section: Discussionmentioning
confidence: 98%
“…Moreover, high blood pressure and atherogenic mechanisms give rise to increased arterial stiffness, which alters cerebral autoregulation and leads to cognitive decline2, but these mechanisms may be prevented by therapy with anti-hypertensive and lipid-lowering drugs. While neurodegeneration may affect blood pressure variation in late life20, gender differences have been reported for the associations of cerebrovascular risk factors with cognitive and functional decline21. This prospective study was aimed to estimate the variations in one year of systolic and diastolic blood pressure in patients with AD, as well as of creatinine clearance, by pharmacogenetic analyses of the effects of ACE inhibitors and statins, while also taking into account possible impacts of these cardiovascular measures over variations of the CHD risk.…”
mentioning
confidence: 99%