2017
DOI: 10.1186/s12933-017-0628-1
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Abstract: BackgroundHypoglycemia is associated with increased mortality rate in patients with diabetes. The underlying mechanisms may involve reduced myocardial tolerance to ischemia and reperfusion (IR) or reduced capacity for ischemic preconditioning (IPC). As IPC is associated with increased myocardial glucose uptake (MGU) during reperfusion, cardioprotection is linked to glucose metabolism possibly by O-linked β-N-acetylglucosamine (O-GlcNAc). We aimed to investigate the impact of hypoglycemia in hearts from animals… Show more

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Cited by 29 publications
(32 citation statements)
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“…Furthermore, early and prolonged exenatide administration, and the use of a long-acting GLP-1 agonist, such as liraglutide, could provide a higher cardioprotective effect, as reported by Chen et al [ 44 ] in myocardial infarction. Finally, by treating hyperglycemia and by favoring hypoglycemia, both exenatide and insulin could have lowered the activation of the cardioprotective pathways [ 43 , 45 ].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, early and prolonged exenatide administration, and the use of a long-acting GLP-1 agonist, such as liraglutide, could provide a higher cardioprotective effect, as reported by Chen et al [ 44 ] in myocardial infarction. Finally, by treating hyperglycemia and by favoring hypoglycemia, both exenatide and insulin could have lowered the activation of the cardioprotective pathways [ 43 , 45 ].…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, acute hyperglycaemia may blunt infarct size reduction by IPC, as well as the protection induced by mitochondrial K ATP channel opener and anaesthetics (Kehl et al, 2002;Kersten et al, 1998 Table 2). Yet studies emphasise that hypoglycaemia and glucose fluctuations, obtained with insulin or sulphonylureas, can aggravate the cardiac susceptibility to acute ischaemia-reperfusion injury and the response to cardioprotective manoeuvres to a greater extent in a non-diabetic when compared with a diabetic model (Paelestik et al, 2017;Saito et al, 2016; see also later section on the effects of anti-hyperglycaemic medications).…”
Section: Type 2 Diabetes Mellitusmentioning
confidence: 99%
“…To the best of our knowledge, ischaemia/reperfusion (I/R) has so far been the principal or only strategy for MI treatment, which is clinically achieved by angioplasty or thrombolytic therapy, thereby promptly restoring blood supply (Vincent et al 2017). Yet, this sudden reperfusion should result in secondary cascade damages, known as myocardial ischaemia/reperfusion injury (MI/RI), which paradoxically deteriorated ischaemic damages and further swelled infarct size (Paelestik et al 2017). In addition, MI/RI may trigger a large variety of pathological changes, including local acute inflammatory reactions, metabolic disorders and cell apoptosis and/or necrosis, ultimately leading to cardiac dysfunction (Kitano et al 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Yet, this sudden reperfusion should result in secondary cascade damages, known as myocardial ischaemia/reperfusion injury (MI/RI), which paradoxically deteriorated ischaemic damages and further swelled infarct size (Paelestik et al. 2017 ). In addition, MI/RI may trigger a large variety of pathological changes, including local acute inflammatory reactions, metabolic disorders and cell apoptosis and/or necrosis, ultimately leading to cardiac dysfunction (Kitano et al.…”
Section: Introductionmentioning
confidence: 99%