Effects of hypertension on the outcomes of COVID-19: a multicentre retrospective cohort study

Abstract

Objectives: Hypertension is thought to be a contributor to mortality in coronavirus disease 2019 patients; however, limited clinical data on the outcomes of COVID-19 in patients with hypertension are available. Methods: This study was designed to confirm whether hypertension affects the outcomes of COVID-19. Results: A total of 983 patients with COVID-19 (female, 48%; male, 52%) were enrolled. Significantly higher odds of 60-day mortality (p = .017) were observed in the hypertensive group. In the hypertensive group, even after adjustment in multivariate analysis, the subgroup of patients 70 years old and older had higher 28-day mortality and total 60-day mortality rates than the other age subgroups (both p < .05). A total of 297 (89%) COVID-19 patients with hypertension survived, and 35 (11%) died. In addition, compared with hypertensive patients who survived COVID-19, non-survivors had more pre-existing conditions, including cardiovascular diseases and stroke, higher blood pressure on admission, more severe inflammation, and more liver and kidney damage. Conclusion: Hypertension does not affect the outcome of COVID-19, which is different than the conclusions drawn in other studies. However, the 28-day mortality and total 60-day mortality rates of hypertensive patients (age ! 70) with COVID-19 were significantly elevated, and compared with the group of survivors, non-surviving COVID-19 patients with hypertension were older, had more basic diseases and had a more severe clinical condition.

Prevalence and risk of COVID-19 in patients with rheumatic diseases: a systematic review and meta-analysis

“…Our article conducted subgroup analysis based on the area, which showed differentiation in the prevalence and clinical characteristics of COVID-19 in rheumatism group. Hypertension was generally considered to be related to the prognosis of severe COVID-19 [ 2 , 6 , 49 ], and a new study denies it [ 50 ]. The incomplete coincidence of conclusions between studies may also be due to the following: the lag and deviation in voluntary data reporting and the lack of detailed information on the countries or continents from which these data are sourced.…”

The Effects of Different Classes of Antihypertensive Drugs on Patients with COVID-19 and Hypertension: A Mini-Review

“…In several other studies, the rate of this infection was found to be higher in men than in women [ 87 , 88 ]. Similarly, the male gender comprised the majority of hospitalized patients affected by COVID-19 [ 89 , 90 ]. Moreover, among the hypertensive population with COVID-19, most patients have been reported to be males [ 89 , 90 ].…”

“…Similarly, the male gender comprised the majority of hospitalized patients affected by COVID-19 [ 89 , 90 ]. Moreover, among the hypertensive population with COVID-19, most patients have been reported to be males [ 89 , 90 ].…”

Clinical outcomes of hospitalized COVID-19 patients with renal injury: a multi-hospital observational study from Wuhan

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