Effects of Healthy Aging on the Regional Cerebral Metabolic Rate of Glucose Assessed with Statistical Parametric Mapping

Differential age effects on cerebral blood flow and BOLD response to encoding: Associations with cognition and stroke risk

“…First, a significant reduction in resting state perfusion in older adults relative to their younger counterparts was observed. This finding is consistent with several ASL, PET, and SPECT studies demonstrating age-related reductions in resting state CBF and cerebral metabolic rate of glucose (e.g., Hagstadius & Risberg, 1989;Parkes et al, 2004;Petit-Taboue et al, 1998), although rates of perfusion decreases have varied. One particularly relevant study of 34 healthy adults (aged 20-67 years) using continuous arterial spin labeling (CASL) reported gray-matter perfusion reduction of 0.45% each year (Parkes et al 2004).…”

Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [18F]Fluorodeoxyglucose–Positron-Emission Tomography Study with Partial Volume Effects Correction: Fig 1.

“…[2][3][4][5][6] Nevertheless, more recent studies have reported decrements in glucose metabolism in several prefrontal, parietal, and temporal areas during the life span, with relative preservation of limbic structures, the cerebellum, and occipital cortex. [7][8][9][10][11][12] One possible explanation for the difference between newer and older reports of aging-associated brain functional variability is the improvement in PET scanners 13 and the development of automated methods of analysis, 14 which together have clearly increased the power to detect CMRglc changes associated with normal aging. However, it has been suggested that such aging-related CMRglc variability in cognitively healthy individuals could be due to PVE, which cause an apparent metabolic reduction in areas with steep GM atrophy and artificial metabolic preservation in areas with less pronounced GM reduction.…”

Bezafibrate Mildly Stimulates Ketogenesis and Fatty Acid Metabolism in Hypertriglyceridemic Subjects

“…A decline in cerebral glucose metabolism is widely reported in AD (Foster et al, 1984;Blennow et al, 2006;Mosconi et al, 2007). This deterioration in brain fuel supply is progressive, correlates broadly with dementia severity, and may appear during normal aging at which time there can be an approximately 6% reduction in glucose uptake per decade (Petit-Taboué et al, 1998). Reduced brain glucose metabolism can arise before the clinical symptoms of AD (Reiman et al, 2004) and may contribute to neurodegenerative processes leading to AD (Liu 2004(Liu , 2008.…”