Effects of Greenshell Mussel (Perna canaliculus) Intake on Pathological Markers of Multiple Phenotypes of Osteoarthritis in Rats

Siriarchavatana, Parkpoom; Kruger, Marlena C.; Miller, Matthew R.; Tian, Huiling; Wolber, Frances M.

doi:10.3390/app10176131

Cited by 5 publications

(11 citation statements)

References 61 publications

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“…The data are consistent with the literature, where a P. canaliculus diet affects visceral fat in rodents (Loehfelm et al., 2020). In addition, the LDL‐C level was significantly reduced in the group with the highest level of P. canaliculus in the diet, thus indicating a reduction in the inflammatory response in several chronic and acute inflammatory disorders such as atherosclerosis, as shown in previous studies (Cetin et al., 2020; Singh et al., 2008; Siriarchavatana et al., 2020; Whitehouse et al., 1997).…”

Section: Discussionsupporting

confidence: 64%

“…The biochemical markers of the renal functions showed that kidney function was not affected by increasing the amount of diet, where creatinine levels were comparable to the control group. Indeed, the BUN/creatinine ratio suggested pre‐renal uremia, which pointed to be associated with a high protein intake, as shown in the literature (Siriarchavatana et al., 2020).…”

Section: Discussionmentioning

confidence: 63%

“…Thus, it would be suggested due to the high levels of protein catabolism derived from the mussels. Accordingly, it was found in the literature that mussels soft‐body contain about 43% proteins (Siriarchavatana et al., 2020). The total protein levels were not affected in all mussels‐containing diet groups, which would indicate that proteins were catabolized, leading to increased urea formation (Matsumoto et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant and antithrombotic effects of green mussels ( Perna canaliculus ) in rats

et al. 2021

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In the past decade, the use of marine mussels as seafood is being more popular. They considered being a rich source of various nutritional bioactive compounds that aroused the scientific community's interest. This study investigated the antioxidant and the antithrombotic consequences on Sprague‐Dawley male rats after adding dried New Zealand mussel Perna canaliculus in their diet. The biochemical, hematological and histopathological changes were also observed. Forty rats were divided into four groups according to the amount of dried mussels in their diet, in addition to a control group that consumed a basal diet only. Group 1 consumed 25% dried mussels in its basal diet; Group 2 consumed 35% dried mussels in its basal diet, and Group 3 was consumed 45% dried mussels in its basal diet. The biochemical parameters showed improvements in liver function. Interestingly, the lipid profile decreased, especially the low‐density lipoprotein cholesterol (LDL‐C) levels which were reduced significantly in Group 3 (p < .01). These observations were accompanied by a decrease in iron levels significantly as the amount of dried mussels increased (p < .01). Furthermore, the noticed changes in the hematological profile prove that there is an increase in antithrombotic activity. Dried mussels had potent antioxidant effects in the liver as shown by increased lipid peroxide (p < .05), reduced glutathione (p < .05), and glutathione peroxidase (GSH‐Px; p < .05). Additionally, antioxidant activity in the kidney was shown to increase through GSH‐Px activity (p < .01). In conclusion, these results indicate that consuming dried mussels resulted in improved biochemical and antioxidants activities and could be used as an antithrombotic agent.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Antioxidant and antithrombotic effects of green mussels ( Perna canaliculus ) in rats

et al. 2021

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“…( 47 ) There was a significant increase of interscapular brown fat due to feeding HFHS diet, but this effect was not present in OVX rats. This conflicting data may not be due to the sole effect of estrogen deficiency but rather combined effects of the hormone and HFHS diet resulting in severely impaired insulin sensitivity, which was revealed by significantly increased HbA1c in the OVX rats fed HFHS diet in our previous report ( 48 ) and which influenced brown fat mass. Similar results of decreased brown fat mass were also revealed in obese male rats with insulin resistance.…”

Section: Discussionmentioning

confidence: 81%

The Influence of Obesity, Ovariectomy, and Greenshell Mussel Supplementation on Bone Mineral Density in Rats

et al. 2021

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Obesity is considered to impair long-term health by disturbing multiple physiological functions. However, it remains a controversial issue as to whether obesity has beneficial or detrimental effects on bone health in postmenopausal women. The aims of this study were to investigate the relationships between obesity and bone mineral density (BMD) under conditions of ovarian hormone deficiency in an animal model and to evaluate the potential health benefits of Greenshell mussel (GSM) on bone health. A total of 144 adult female Sprague-Dawley rats were fed from age 12 weeks on one of four diets (normal [ND]; ND + GSM; high fat/high sugar [HF/HS]; HF/HS + GSM; n = 36 per diet). At age 20 weeks, after a dual-energy X-ray absorptiometry (DXA) scan, 12 of the rats on each diet underwent ovariectomy (OVX) and the remaining rats were left intact. Twelve of the intact rats in each diet group were culled at age 26 weeks (short-term cohort). The remaining rats were culled at age 48 weeks (long-term cohort). Rats were DXA scanned before cull, then various fat pads were dissected. The results revealed that HF/HS rats and OVX rats dramatically increased body weight and fat deposition in correlation with leptin. In the long-term cohort, vertebral spine BMD rapidly declined after OVX. At termination, the OVX rats had decreased plasma bone turnover markers of CTX-1 and TRAP when compared with sham rats. Significantly higher BMD was found in OVX rats fed the HF/HS diet compared with ND, but this difference was not recapitulated in intact rats. BMD of right femur was significantly increased 5% to 10% by GSM in the short-term cohort. The data demonstrated that obesity can be beneficial by increasing BMD in OVX rats, and this may extrapolate to postmenopausal women as adipocyte-produced estrogen may slightly compensate for the reduction in ovarian hormones. Finally, the data showed that GSM may be beneficial to bone health by increasing BMD accrual.

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“…This model has been frequently used in obesity research as the convenience of the protocol and representing the public health problem. The surgical model using ovariectomy in female subjects can mimic the menopause condition in women as estrogen loss induces increased food consumption at the transitional period (Siriarchavatana et al, 2022) and worsens metabolic and lipid profiles (Siriarchavatana et al, 2020;Abshirini et al, 2021). Boonyapakorn et al (2019) demonstrated that lacks of testosterone in castrated dogs resulted in significant weight gain due to the reduction of physical activities but this manipulation did not affect metabolic profiles or cardiac function.…”

Section: Discussionmentioning

confidence: 99%

Correlation between body condition score and body composition in a rat model for obesity research

Siriarchavatana

Kruger

Wolber

2022

VIS

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The incidences of obesity-associated chronic diseases are increasing worldwide. Research into the causes of obesity as well as potential treatments has highlighted the crucial role of preclinical studies using animal models. Rats are one of the most widely used species in obesity research. However, even with decades of research in both genetically obese rats and diet-induced obese rat models, definitive criteria to practically classify levels of obesity in the rat are not well established. The current study proposes new criteria modified from a 5-point body condition score (BCS) using in an animal health monitoring system and added a half-point scale to extend the range of body weight associated with subcutaneous fat deposition. The modified criteria were tested and compared with body composition from dual energy X-ray absorptiometry scans and selected adipose tissue weights. The results showed that the modified body condition scale was highly correlated with fat deposition in the rat body, particularly the visceral and inguinal fat pads. Both pads were closely related to changes in some specific landmarks used for the scale determination. These finding should extrapolate to obese rats in other models, with the advantage that data classified in BCS can pair the animal data with human body mass index. This will enhance the value of information from preclinical studies to design and predict outcomes of subsequent human clinical trials.

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Effects of Greenshell Mussel (Perna canaliculus) Intake on Pathological Markers of Multiple Phenotypes of Osteoarthritis in Rats

Cited by 5 publications

References 61 publications

Antioxidant and antithrombotic effects of green mussels ( Perna canaliculus ) in rats

Antioxidant and antithrombotic effects of green mussels ( Perna canaliculus ) in rats

The Influence of Obesity, Ovariectomy, and Greenshell Mussel Supplementation on Bone Mineral Density in Rats

Correlation between body condition score and body composition in a rat model for obesity research

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