Effects of Gossypol on the fertility of male rats, hamsters and rabbits

Chang, M. C.; Gu, Zhi-ping; Saksena, S.K.

doi:10.1016/0010-7824(80)90011-6

Cited by 136 publications

(40 citation statements)

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“…The weights of the reproductive organs were not altered by gossypol treatment in the present work, indicating that gossypol did not cause systemic effects, even in the intact group, that lost body weight . Other studies report no effect of gossypol on testis weight Soufir et al, 1989;Chang et al, 1980;Kaur et al, 1988) while some observed a decrease in testis weight (Srivastava et al, 1989). Changes in epididymal weight following gossypol exposure are equally conflicting, with a decrease observed in some studies (Srivastava et al, 1989;Bhiwgade and Nair, 1989;Soufir et al, 1989;Taylor et al, 1991) and no decrease observed in other studies (Swan et al, 1990;Wang et al, 1984;Chang et al, 1980;Kaur et al, 1988).…”

Section: Discussionmentioning

confidence: 97%

Epididymis-Specific Pathologic Disorders in Rats Exposed to Gossypol from Weaning Through Puberty

et al. 2006

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Previous work in our laboratory revealed that the pubertal period of reproductive development in the male rat was particularly vulnerable to gossypol exposure, with a higher frequency of round structures in the lumen of the cauda epididymidis in the treated rats. Herein, we utilized hemicastration and electron microscopy to confirm that the epididymis is a definitive target of gossypol. Although exposure to gossypol from weaning through puberty caused a significant decrease in daily sperm production, as well as in the concentration of sperm in the epididymis, serum testosterone levels and reproductive organ weights were not altered. In gossypol treated rats, sperm morphology was compromised severely, but the epithelium in testis and epididymis appeared morphologically normal. Ultrastructural examination revealed that round structures, present only in gossypol exposed males, represented: (1) principal cells exfoliated from the epididymal epithelium; (2) epididymal epithelial cell cytoplasm containing degenerating sperm; and (3) degenerating epithelial cells, consisting of vesicles and particles of different sizes, forms and densities. Taken together, the data confirm that gossypol targets the epididymis, disturbing both the structure and function of this organ, and presumably disrupts sperm maturation.

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Section: Discussionmentioning

confidence: 97%

Epididymis-Specific Pathologic Disorders in Rats Exposed to Gossypol from Weaning Through Puberty

et al. 2006

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“…Chang et al [4] have shown inhibition of sperm motility in rats and hamsters after gossypol treatment (5-10 mg/kg body weight for 8-14 weeks). Weinbauer et al…”

Section: Resultsmentioning

confidence: 99%

Semen Characteristics of Gossypol-Treated Langurs (Presbytis Entellus Entellus Dufresne)

Bhargava

1984

Archives of Andrology

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Gossypol isolated from cottonseed was fed to sexually adult male langurs at 50 and 100 mg/kg body weight per day for 90 days. Semen was collected every 2 wk, and the observations made on semen characteristics showed gossypol's detrimental effect The gossypol administration caused a significant decline in percent sperm cells motility and a significant rise in abnormalities. The semen characteristics returned to normal levels during a 180-day recovery period following the discontinuation of gossypol treatment. A clear relationship exists between the inhibition of sperm cell motility and dose as well as duration of gossypol treatment. The testicular biopsies taken from two langurs after 90 days of gossypol treatment showed normal histoarchitecture at both the dose levels.

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“…Oral administration of gossypol or gossypol acetic acid to male rats at a dosage of 15-40 mg/kg body weighVday for 2-4 weeks also induced infertility [ 1 I]. Similar results were observed in hamster but not in rabbit [4]. The antifertility effect was denoted by the presence of dead spermatozoa in the caudal epididymis and by the presence of abnormal spermatozoa in the testes [6].…”

Section: Introductionmentioning

confidence: 87%

Effect of Gossypol on Boar Spermatozoa in Vitro

Tso¹,

Lee²

1981

Archives of Andrology

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Gossypol, the active component in cottonseed oil, inhibits spermatogenesis in many mammals. Gossypol enhanced respiration and abolished forward motility of boar spermatozoa. The effective concentration was M, similar to that reported in its uncoupling of oxidative phosphorylation in rat liver mitochondria. Its antifertility effect may be a combination of the effect on the developing spermatids as well as that on spermatozoal motility.

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Effects of Gossypol on the fertility of male rats, hamsters and rabbits

Cited by 136 publications

References 1 publication

Epididymis-Specific Pathologic Disorders in Rats Exposed to Gossypol from Weaning Through Puberty

Epididymis-Specific Pathologic Disorders in Rats Exposed to Gossypol from Weaning Through Puberty

Semen Characteristics of Gossypol-Treated Langurs (Presbytis Entellus Entellus Dufresne)

Effect of Gossypol on Boar Spermatozoa in Vitro

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