Effects of glucose modulation in lateral hypothalamus on motivated behavior to obtain sucrose in an operant task

Stamos, Joshua P.; Stalnaker, Katherine J.; Teegala, Suraj B.; Routh, Vanessa H.; Beck, Kevin D.

doi:10.1016/j.appet.2023.106621

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…In some animals, low density DREADD expression was also observed in a small medial portion of the caudate putamen, globus pallidus, ventral pallidum, and other surrounding regions. Hence, we cannot definitely attribute all effects to manipulation of the BNST, as some other regions expressing DREADD have been shown to be involved in socio-sexual behavior 39 , ingestive behavior 40,41 , and/or reward and motivation [42][43][44] . However, most DREADD was expressed in the BNST.…”

Section: Discussionmentioning

confidence: 99%

CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state

Huijgens,

Heijkoop,

Vanderschuren

et al. 2023

Preprint

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This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context of sexual behavior and sucrose self-administration. The role of CaMKIIa+ neurons in the bed nucleus of the stria terminalis (BNST) was explored using chemogenetic silencing and stimulation techniques. Additionally, the study examined how these effects interacted with the internal state of the animals. Through detailed behavioral analysis, it was demonstrated that CaMKIIa+ neurons in the BNST play a significant role in the regulation of both sexual behavior and sucrose self-administration. Although the behavioral outcome measures differed between the two behaviors, the regulatory role of the CaMKIIa+ neurons in the BNST was found to converge on the modulation of the pacing of engagement in these behaviors in male rats. Moreover, our study confirmed that the internal physiological state of the animal affects how the BNST modulates these behaviors. These findings suggest that different types of natural rewards may recruit a similar brain circuitry to regulate the display of motivated behaviors. Overall, this research provides valuable insights into the neural mechanisms underlying natural reward seeking and sheds light on the interconnected nature of reward-related behaviors in male rats.

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Section: Discussionmentioning

confidence: 99%

CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state

Huijgens,

Heijkoop,

Vanderschuren

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state

Huijgens,

Heijkoop,

Vanderschuren

et al. 2024

Psychopharmacology

View full text Add to dashboard Cite

This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context of sexual behavior and sucrose self-administration. The role of CaMKIIa+ neurons in the bed nucleus of the stria terminalis (BNST) was explored using chemogenetic silencing and -stimulation. Additionally, the study examined how these effects interacted with the internal state of the animals. Through detailed behavioral analysis, it was demonstrated that CaMKIIa+ neurons in the BNST play a significant role in the regulation of both sexual behavior and sucrose self-administration. Although the behavioral outcome measures differed between the two behaviors, the regulatory role of the CaMKIIa+ neurons in the BNST was found to converge on the modulation of the pacing of engagement in these behaviors in male rats. Moreover, our study confirmed that the internal physiological state of the animal affects how the BNST modulates these behaviors. These findings suggest that different types of natural rewards may recruit a similar brain circuitry to regulate the display of motivated behaviors. Overall, this research provides valuable insights into the neural mechanisms underlying natural reward seeking and sheds light on the interconnected nature of reward-related behaviors in male rats.

show abstract

Effects of glucose modulation in lateral hypothalamus on motivated behavior to obtain sucrose in an operant task

Cited by 2 publications

References 28 publications

CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state

CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state

CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state

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