Effects of genistein aglycone in glucocorticoid induced osteoporosis: A randomized clinical trial in comparison with alendronate

Squadrito, Francesco; Imbalzano, Egidio; Rottura, Michelangelo; Arcoraci, Vincenzo; Pallio, Giovanni; Catalano, Antonino; Atteritano, Marco; Irrera, Natasha; Mannino, Federica; Squadrito, Giovanni; Vaccaro, Mario; Irrera, Pierangela; Pirrotta, Igor; Bitto, Alessandra

doi:10.1016/j.biopha.2023.114821

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…On the contrary, although an improvement in SP was observed in both groups, it was a not significant change, probably because of the great variability of SP degree found in CVI affected patients [47][48][49]. Although brown pigmentation of the skin has been reported to be due to the accumulation of hemosiderin or melanin, hemosiderin is believed to be the primary factor [47][48][49][50].…”

Section: Discussionmentioning

confidence: 79%

Effects of a Dietary Supplement Composed of Baicalin, Bromelain and Escin for Venous Chronic Insufficiency Treatment: Insights from a Retrospective Observational Study

Drago,

Rottura,

Molonia

et al. 2024

Pharmaceuticals

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Chronic venous insufficiency (CVI) represents a risk factor for cardiovascular events. The first-line treatment includes the use of compression stockings and lifestyle changes. Natural products, such as flavonoids, could be used to improve the effects of compression therapy due to their anti-inflammatory and anti-oxidant properties. This study aims to evaluate the effects of a dietary supplement containing baicalin, bromeline and escin in CVI patients. A retrospective cohort study was performed by using the medical records of CVI affected outpatients. Patients treated with the dietary supplement were defined as “users”. A modified Venous Clinical Severity Score (VCSS) was calculated, including pain, inflammation, vessels induration and skin pigmentation. All clinical variables were evaluated at baseline (T0), after 30 (T1) and 90(T2) days in “users” and “non-users”. Out of 62 patients, 30 (48.4%) were “users”. No difference was observed between groups at baseline. A lower VCSS value was recorded in “users” than that observed in “non-users” at T2 (7.0 (4.0–9.0) vs. 9.0 (5.0–10.0); p = 0.025). Vessels’ induration and pain significantly reduced in 53.3% and 43.3% of “users” and in 18.8% and 9.4% of “non-users”. Only “users” (33.3%) showed a reduction of the inflammatory signs as well as a decrease in malleolar circumference, from 29.0 (26.5–30.0) to 27.5 (26.0–28.5) (p < 000.1). A reduction of C-reactive Protein levels was found in “users” compared to “non-users” at T2 (1.0 (0.9–1.2) vs. 1.3 (1.0–1.5); p = 0.006). These findings suggest that implementation of a dietary supplement could improve the clinical outcomes of CVI patients.

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Section: Discussionmentioning

confidence: 79%

Effects of a Dietary Supplement Composed of Baicalin, Bromelain and Escin for Venous Chronic Insufficiency Treatment: Insights from a Retrospective Observational Study

Drago,

Rottura,

Molonia

et al. 2024

Pharmaceuticals

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“…Zhang et al 2020 [9] found that the isoflavone group's mean changes in BMD values were significantly higher than the control group's after three months of phytoestrogen intervention (-0.29 ± 0.17 vs. -0.31 ± 0. [10] used genistein (0.77 g/cm2 from baseline to 0.80 g/cm2 at 24 months, P<0.05).…”

Section: Bone Mineral Density (Bmd) Analysismentioning

confidence: 99%

“…These findings suggest that phytoestrogens protect against bone loss by stimulating osteoblastic bone formation and inhibiting bone resorption [13]. Interestingly, a study by Squadrito et al discovered that phytoestrogens had similar effects and did not differ significantly from alendronate, the first-line treatment for osteoporosis [10].…”

Section: Other Serum Bone Biomarkers Analysismentioning

confidence: 99%

“…Premenopausal women with osteoporosis, due to lower levels of estrogen, are advised to begin treatment with HRT [9]. In contrast, males with osteoporosis may be prescribed first-line treatment in the form of bisphosphonates [10]. On the other hand, HRT has been linked to an increased risk of coronary heart disease, breast cancer, pulmonary embolism (PE), and stroke, and bisphosphonate consumption can result in jaw osteonecrosis and atypical fracture [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…In a separate study, Corbi et al(2023) [39] found that fermented soy increased BMD by a percentage between baseline and final values (+3.17 ± 2.74%, p < 0.0001). Guo et al(2018) [40] found that using Xianling herb capsules before and after intervention increased BMD (0.891 ± 0.166 vs 0.672 ± 0.141, p < 0.05), andSquadrito et al (2023)…”

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confidence: 99%

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Comprehensive Analysis of Phytoestrogens Intervention in Osteoporosis Management: A Systematic Review of Randomized Controlled Trials

Sutrisno,

Widowati

2023

a-jhr

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Introduction: Osteoporosis is a medical condition characterized by increased bone turnover and decreased bone mass, which leads to bone fractures. Antiresorptive therapy, hormone replacement therapy (HRT), and bisphosphonates are used as first-line therapy related to numerous side effects. The osteoprotective properties of phytoestrogens are well known. This systematic review aims to explore the potential of phytoestrogen in the management of osteoporosis patients based on serum bone biomarker analysis. Methods: The literature search was conducted in six databases. The outcome of interest measures the mean changes in bone mineral density (BMD) and other serum bone biomarkers. Various forms of phytoestrogen intervention were used, including isoflavone extracts with an administered dose (tablets, capsules), genistein extract (tablets), resveratrol, and isolated soy protein (IBS) in powder form, beverages, food and snacks, and soy products. Quality appraisal was done using the Cochrane Risk of Bias Tool 2. Ten articles were included in the systematic review. Results: Seven studies found the mean changes in BMD values were significantly higher than the control group's after phytoestrogen intervention. Phytoestrogens dramatically boost numerous bone formation markers, including calcium, phosphorus, Ca/P ratio, and vitamin D, followed by a drop in BAP and osteocalcin levels. Phytoestrogens dramatically increased numerous bone formation markers, including calcium, phosphorus, Ca/P ratio, and vitamin D, followed by a decrease in BAP and osteocalcin levels. Furthermore, intervention may reduce bone resorption indicators such as CTX, RANKL, AKP, OPG, DPD, and PTH. Conclusion: Phytoestrogen intervention has demonstrated effectiveness in increasing bone mineral density and serum bone biomarkers.

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Efficient recovery of genistein from soy sauce residue via UiO-66-F4(Zr) modified with hydrophobic ligands

Yang,

Yao,

Zhou

et al. 2024

Chemical Physics Letters

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Effects of genistein aglycone in glucocorticoid induced osteoporosis: A randomized clinical trial in comparison with alendronate

Cited by 6 publications

References 26 publications

Effects of a Dietary Supplement Composed of Baicalin, Bromelain and Escin for Venous Chronic Insufficiency Treatment: Insights from a Retrospective Observational Study

Effects of a Dietary Supplement Composed of Baicalin, Bromelain and Escin for Venous Chronic Insufficiency Treatment: Insights from a Retrospective Observational Study

Comprehensive Analysis of Phytoestrogens Intervention in Osteoporosis Management: A Systematic Review of Randomized Controlled Trials

Efficient recovery of genistein from soy sauce residue via UiO-66-F4(Zr) modified with hydrophobic ligands

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