Effects of Gastrodiae rhizoma on proliferation and differentiation of human embryonic neural stem cells

Baral, Samrat; Pariyar, Ramesh; Yoon, Chi–Su; Kim, Dongcheol; Yun, Jong Min; Jang, Seok O.; Kim, Sung Yeon; Oh, Hyuncheol; Kim, Youn‐Chul; Seo, Jooyeok

doi:10.1016/j.apjtm.2015.09.004

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Regarding NSC differentiation, the expressions of specific neural markers including nestin, neuron‐specific class III beta‐tubulin (TuJ1) and MAP‐2 were assessed using quantitative reverse transcription polymerase chain reaction and immunocytochemistry, resulting in a high expression of TuJ1 and MAP‐2, whereas a decreased expression of nestin was observed. The differential gene expression suggests that EEGR induces NSC differentiation, as nestin is considered an early differentiation marker specific to NSCs, contrary to TuJ1 and MAP‐2 that are specific to neurons 53 . It would be interesting if electrophysiology techniques were to be included in these studies in order to evaluate cell functionality, neuron–glia communication and synaptic transmission.…”

Section: Effect Of Plant Derivatives On Stem Cell Differentiationmentioning

confidence: 99%

“…The differential gene expression suggests that EEGR induces NSC differentiation, as nestin is considered an early differentiation marker specific to NSCs, contrary to TuJ1 and MAP-2 that are specific to neurons. 53 It would be interesting if electrophysiology techniques were to be included in these studies in order to evaluate cell functionality, neuron-glia communication and synaptic transmission.…”

Section: Neural Stem Cellsmentioning

confidence: 99%

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Stem cell culture media enriched with plant‐derived compounds: Cell differentiation enhancement

Chairez‐Cantu

Ornelas‐González

Ortiz‐Martínez

et al. 2021

J of Chemical Tech & Biotech

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The development of cell therapies to replace lost or damaged cells has attracted interest in the regenerative medicine field due to the multilineage differentiation ability of stem cells. However, there are some drawbacks regarding optimization in the differentiation protocols to obtain high efficiency and further translation into clinic settings, which have led to the identification of specific compounds that could overcome these challenges. For years, plants have been associated with useful therapeutic effects for the treatment of some human diseases due to their high content of bioactive compounds. These plant derivatives act as growth factors that could either modulate or promote cell differentiation by the activation of specific signaling pathways. In this context, the administration of stem cells supplemented with these compounds could have better outcomes as a treatment. Hence, supplementing stem cell culture with plant derivatives represents a cost‐effective strategy, as the purification of plant extracts is of relatively low cost compared to the production of recombinant growth factors, and also their use facilitates the compliance of good manufacturing practice guidelines compared to xenogeneic compounds. This review aims to describe the mechanism of action of the most well‐studied plant derivatives involved in cell differentiation enhancement, particularly in osteogenic and neural lineages. Additionally, current trends and challenges that must be addressed for successful implementation in clinical applications are discussed. © 2021 Society of Chemical Industry (SCI).

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Section: Effect Of Plant Derivatives On Stem Cell Differentiationmentioning

confidence: 99%

Section: Neural Stem Cellsmentioning

confidence: 99%

Stem cell culture media enriched with plant‐derived compounds: Cell differentiation enhancement

Chairez‐Cantu

Ornelas‐González

Ortiz‐Martínez

et al. 2021

J of Chemical Tech & Biotech

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show abstract

“…Gastrodiae rhizome [ 27 ], Astragalus mongholicus [ 28 ], Angelica [ 29 ], and other herbs are well-known, and many researchers have studied their effects on the proliferation and differentiation of NSCs. In conclusion, Chinese herbal medicine has shown great potential in inducing the proliferation and differentiation of NSCs.…”

Section: Chemical Factorsmentioning

confidence: 99%

The Effects of Different Factors on the Behavior of Neural Stem Cells

Huang

Wang

2017

Stem Cells International

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The repair of central nervous system (CNS) injury has been a worldwide problem in the biomedical field. How to reduce the damage to the CNS and promote the reconstruction of the damaged nervous system structure and function recovery has always been the concern of nerve tissue engineering. Multiple differentiation potentials of neural stem cell (NSC) determine the application value for the repair of the CNS injury. Thus, how to regulate the behavior of NSCs becomes the key to treating the CNS injury. So far, a large number of researchers have devoted themselves to searching for a better way to regulate the behavior of NSCs. This paper summarizes the effects of different factors on the behavior of NSCs in the past 10 years, especially on the proliferation and differentiation of NSCs. The final purpose of this review is to provide a more detailed theoretical basis for the clinical repair of the CNS injury by nerve tissue engineering.

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Recent Research Progress on the Antidepressant-like Effect and Neuropharmacological Potential of Gastrodia elata Blume

Lin

Sheen

2018

Curr Pharmacol Rep

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Effects of Gastrodiae rhizoma on proliferation and differentiation of human embryonic neural stem cells

Abstract: In conclusion, our study demonstrates for the first time that EEGR induced proliferation and neuronal differentiation of NSCs, suggesting its potential benefits on NSC-based therapies and neuroregeneration in various neurodegenerative diseases and brain injuries.

Cited by 6 publications

References 26 publications

Stem cell culture media enriched with plant‐derived compounds: Cell differentiation enhancement

Stem cell culture media enriched with plant‐derived compounds: Cell differentiation enhancement

The Effects of Different Factors on the Behavior of Neural Stem Cells

Recent Research Progress on the Antidepressant-like Effect and Neuropharmacological Potential of Gastrodia elata Blume

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