Effects of Fusarium mycotoxins with yeast cell wall absorbent on hematology, serum biochemistry, and oxidative stress in broiler chickens

Jiang, Shuzhen; Li, Zongchen; Wang, G. Y.; Yang, Zhiru; Yang, Weiren; Zhang, G. G.; Wu, Yuanyuan

doi:10.3382/japr.2013-00830

Cited by 28 publications

(21 citation statements)

References 27 publications

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“…The elevated levels of WBC and reduced count of PLT were restored by LpMYS6 administration. Jiang et al (2014) showed that supplementation of yeast cell wall absorbent had a protective effect on WBC, lymphocytes, PLT, and hemoglobin in broilers fed with mycotoxin-contaminated feed. Further, oral administration of LpMYS6 significantly restored the altered levels of serum parameters such as SGOT, SGPT, creatinine, cholesterol, triglycerides and albumin, both in the pre-colonization and challenge study.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum MYS6 Ameliorates Fumonisin B1-Induced Hepatorenal Damage in Broilers

et al. 2017

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Fumonisin B1 (FB1), a mycotoxin produced by Fusarium species is a predominant Group 2B carcinogen occurring in maize and maize-based poultry feeds. It is shown to be nephrotoxic, hepatotoxic, neurotoxic, and immunosuppressing in animals. In this study, we report the ameliorating effects of a probiotic strain, Lactobacillus plantarum MYS6 on FB1-induced toxicity and oxidative damage in broilers. A 6-week dietary experiment consisting of 48 broilers was performed in six treatment groups. Probiotic treatment (109 cells/mL) involved pre-colonization of broilers with L. plantarum MYS6 while co-administration treatment involved supplementation of probiotic and FB1-contaminated diet (200 mg/Kg feed) simultaneously. At the end of the treatment period, growth performance, hematology, serum biochemistry, and markers of oxidative stress in serum and tissue homogenates were evaluated in all the broilers. The histopathological changes in hepatic and renal tissues were further studied. The results demonstrated that administration of L. plantarum MYS6 efficiently improved the feed intake, body weight and feed conversion ratio in broilers. It mitigated the altered levels of hematological indices such as complete blood count, hemoglobin, and hematocrit. Serum parameters such as serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, creatinine, cholesterol, triglycerides, and albumin were significantly restored after administering the probiotic in FB1-intoxicated broilers. Additionally, L. plantarum MYS6 alleviated the levels of oxidative stress markers in serum and tissue homogenate of liver. The histopathological data of liver and kidney further substantiated the overall protection offered by L. plantarum MYS6 against FB1-induced cellular toxicity and organ damage in broilers. Our results indicated that co-administration of probiotic along with the toxin had better effect in detoxification compared to its pre-colonization in broilers. Collectively, our study signifies the protective role of L. plantarum MYS6 in ameliorating the FB1-induced toxicity in the vital organs and subsequent oxidative stress in broilers. The probiotic L. plantarum MYS6 can further be formulated into a functional feed owing to its anti-fumonisin attributes and role in mitigating FB1-induced hepatorenal damage.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum MYS6 Ameliorates Fumonisin B1-Induced Hepatorenal Damage in Broilers

et al. 2017

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“…Although the acute mode of action of YCW is not clear, Raju and Devegowda (2000) hypothesized that mycotoxin molecule might be attached to glucomannan matrix from YCW which prevents toxin absorption from intestinal tract and the subsequent toxin-induced tissue damages. Previous studies in our laboratory indicated that dietary addition of YCW at the level of 0.20% to naturally contaminated diets caused a protective effect on liver and spleen at 21 day of age, relative weight of bursa of fabricius and thymus at 42 day of age, antibody titers of Newcastle disease at both 28 and 42 day of age of broilers (Li et al, 2012;Jiang et al, 2014).…”

Section: Discussionmentioning

confidence: 76%

Effects of feeding naturally contaminated diet with zearalenone, fumonisin and deoxynivalenol with or without yeast cell wall adsorbent on growth, vulva size and organ weights of gilts

Liu¹,

Yang²,

Yang³

et al. 2016

J. Anim. Feed Sci.

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“…Previous studies exhibited that lycopene increased GSH concentration and improved activities of antioxidases in AFB 1 and zearalenone challenged rats and mice [10,17,39], and increased antioxidant capacity in heat-stressed broilers [19]. Similarly, the oxidative stress induced by mycotoxins and anti-stress ability of plant-derived additives with antioxidant capacity in animals have been recognized [8,9,[40][41][42]. Therefore, it is convincible that lycopene can effectively relieve the oxidative damage in animals exposed to mycotoxins not only through improving enzymatic antioxidant system, but also through ameliorating non-enzymatic antioxidant system.…”

Section: Discussionmentioning

confidence: 95%

Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxification and antioxidant systems in broiler chickens

Wan

Yang

et al. 2020

Preprint

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Background Dietary constituents in certain bioactive substances may alleviate the toxicity of aflatoxin B1 (AFB1). Lycopene is a natural bioactive substance with powerful antioxidant, this study investigated whether dietary lycopene supplementation could alleviate AFB1-induced liver damage through inhibiting cytochrome P450 (CYP450) isozymes and improving detoxification and antioxidation with nuclear factor erythroid 2-related factor 2 (Nrf2) activation in broiler chickens. 320 healthy one-day-old male broiler chickens were randomly allotted into five groups and fed basal diet (Control), basal diet with AFB1 and 0, 100, 200 or 400 mg/kg lycopene, respectively. At 42 days of age, 8 broiler chickens per group were sampled.Results Compared to the control group, AFB1-exposed birds had depressed growth performance, hepatotoxicity and oxidative damage. The various lycopene levels prevented AFB1-induced growth depression, decreased activities and mRNA expressions of hepatic CYP450 isozymes, reduced reactive oxygen species and oxidative damage products, improved reduced glutathione (GSH)-dependent detoxification system and antioxidant system. Moreover, lycopene elevated the mRNA expressions of Nrf2 and its target genes, containing glutathione-s-transferase isozymes, GSH synthesis-related enzymes and antioxidases in AFB1-exposed broiler chickens.Conclusions As an effective anti-stress and hepatoprotective antioxidant, lycopene alleviated AFB1-induced liver damage possibly through inhibiting CYP450 isozymes and improving Nrf2-mediated detoxification and antioxidant systems in broiler chickens. Therefore, Lycopene and lycopene-enriched materials could be taken into consideration as effective hepatoprotective and anti-stress additives in poultry, and benefit the resulting food safety.

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Effects of Fusarium mycotoxins with yeast cell wall absorbent on hematology, serum biochemistry, and oxidative stress in broiler chickens

Cited by 28 publications

References 27 publications

Lactobacillus plantarum MYS6 Ameliorates Fumonisin B1-Induced Hepatorenal Damage in Broilers

Lactobacillus plantarum MYS6 Ameliorates Fumonisin B1-Induced Hepatorenal Damage in Broilers

Effects of feeding naturally contaminated diet with zearalenone, fumonisin and deoxynivalenol with or without yeast cell wall adsorbent on growth, vulva size and organ weights of gilts

Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxification and antioxidant systems in broiler chickens

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