Effects of Formulation Variables and Storage Conditions on Light Protected Vitamin B12 Mixed Parenteral Formulations

Monajjemzadeh, Farnaz; Ebrahimi, Fatemeh; Zakeri–Milani, Parvin; Valizadeh, Hadi

doi:10.5681/apb.2014.048

Cited by 15 publications

(7 citation statements)

References 15 publications

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“…Thus, CNCbl contents remained at >95% of the labeled claim after 12 months of storage at room temperature in all three single-ingredient preparations, whereas its contents decreased to 28-37% of the labeled claim in the four multi-ingredient preparations [151]. CNCbl degradation in commercial parenteral preparations containing thiamine and pyridoxine, after two months of their light-protected storage at 40 • C, was additionally confirmed by Monajjemzadeh et al By evaluating the CNCbl stability after 5 days at 55 • C in experimentally prepared parenteral formulations containing different CNCbl, thiamine, and pyridoxine combinations, they confirmed the CNCbl stability in a single-ingredient CNCbl solution as well as in combination with pyridoxine (97%) and its degradation in solutions with thiamine (79%) and especially in combination with thiamine and pyridoxine (41%) [150]. Recently, there is an increasing number of studies that highlight the photolability of MeCbl in liquid dosage forms and the need for its light-protected storage and proper stabilization [212][213][214].…”

Section: Vitamin B 12 Stability In Foodsmentioning

confidence: 54%

“…As reported above, Bajaj and Singhal evaluated CNCbl degradation kinetics at less extreme pH values (2, 4, 6, 8, and 10) at three temperatures (4, 25, and 37 • C) with the highest degradation extent and rate at pH 2 and lowest at pH 6 [142]. Other papers report the highest CNCbl stability in different pH ranges: 4-7 [3,117], 4-6.5 [150], 4.5-5 [151], and 4-4.5 [131]. The official requirements for the pH of CNCbl solutions are 4.0-5.0 for CNCbl oral solution in the British Pharmacopeia [152], and 4.5-7.0 for CNCbl injections in the United States Pharmacopeia [153].…”

Section: Ph Of the Solutionmentioning

confidence: 92%

“…Doerge et al identified the thiol-containing thiamine degradation product, cysteine, as responsible for CNCbl degradation [191]. This destabilization effect is enhanced by the presence of high thiamine concentrations and the presence of pyridoxine or nicotinamide [150,177,192].…”

Section: Vitamin B 12 -Thiaminementioning

confidence: 99%

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Vitamin B12 in Foods, Food Supplements, and Medicines—A Review of Its Role and Properties with a Focus on Its Stability

et al. 2022

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Vitamin B12, also known as the anti-pernicious anemia factor, is an essential micronutrient totally dependent on dietary sources that is commonly integrated with food supplements. Four vitamin B12 forms—cyanocobalamin, hydroxocobalamin, 5′-deoxyadenosylcobalamin, and methylcobalamin—are currently used for supplementation and, here, we provide an overview of their biochemical role, bioavailability, and efficacy in different dosage forms. Since the effective quantity of vitamin B12 depends on the stability of the different forms, we further provide a review of their main reactivity and stability under exposure to various environmental factors (e.g., temperature, pH, light) and the presence of some typical interacting compounds (oxidants, reductants, and other water-soluble vitamins). Further, we explore how the manufacturing process and storage affect B12 stability in foods, food supplements, and medicines and provide a summary of the data published to date on the content-related quality of vitamin B12 products on the market. We also provide an overview of the approaches toward their stabilization, including minimization of the destabilizing factors, addition of proper stabilizers, or application of some (innovative) technological processes that could be implemented and contribute to the production of high-quality vitamin B12 products.

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Section: Vitamin B 12 Stability In Foodsmentioning

confidence: 54%

Section: Ph Of the Solutionmentioning

confidence: 92%

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Vitamin B12 in Foods, Food Supplements, and Medicines—A Review of Its Role and Properties with a Focus on Its Stability

et al. 2022

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“…4 [57]. Physical and chemical factors such as light, heat, moisture, oxidizing and reducing agents, acids and bases all impact the stability of vitamin B negatively [58]. A study on fortification of freeze-dried meals demonstrated that this method would be a significantly fruitful means of improving the quality of military pack meals that addresses shortfalls in vitamin B levels [59].…”

Section: Vitamin Bmentioning

confidence: 99%

A Synthesis Review of Vitamins Involved in the Fight against Covid‐19

Mciteka

2023

ChemBioEng Reviews

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Although literature studies on earlier viruses such as the Severe Acute Respiratory Syndrome (SARS), the Middle East Respiratory Syndrome (MERS), and other similar viruses, in terms of treatment of coronavirus suggested the repurposing of some antiviral drugs, some Covid-19 specific treatments, general forms of treatments, the use of convalescent plasma, as well as nutritional interventions in the form of vitamins, it is imperative to interrogate the nutritional status, age, and comorbidities of each infected patient before receiving any form of treatment. In the absence of any conclusive treatment so far, the study encourages the use of all likely interventions that could help arrest the spread of the disease. In addition, the current study has a particular interest in the syntheses and applications of vitamins and their derivatives which have been touted to play a significant role in the fight against Covid-19, namely, vitamins A-E. It must, however, be mentioned that literature is not comprehensive.

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“…Es posible administrar las vitaminas B neurotrópicas para el tratamiento de la neuropatía periférica de forma combinada por vía oral, sin embargo, es importante tener presente que debe evitarse su administración conjunta por vía parenteral debido a incompatibilidad farmacéutica entre la vitamina B12 y los otros componentes de la formulación (141). Además, la vitamina B12 es altamente fotosensible, con el consecuente riesgo de degradación de la molécula (142).…”

Section: Consideraciones Farmacéuticasunclassified

Vitaminas B neurotrópicas y neuropatía periférica: estado del arte y acuerdo de expertos

Calderón-Ospina,

Palacios-Sánchez,

Nava-Mesa

et al. 2023

Acta Neurol Colomb

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Propósito: la neuropatía periférica tiene un espectro clínico inespecífico y multifactorial, con frecuente subdiagnóstico y terapéutica de eficacia variable. Existe una heterogénea prescripción de vitaminas B, las cuales pueden desempeñar un rol importante en el manejo de diferentes neuropatías; sin embargo, en Colombia no existen guías clínicas al respecto. El propósito de este trabajo es orientar en el reconocimiento temprano de las neuropatías periféricas y genera recomendaciones sobre el uso adecuado de vitaminas B neurotrópicas. Descripción de la metodología: acuerdo de expertos sobre la neuropatía periférica y el rol terapéutico de las vitaminas B con énfasis en la epidemiología en Colombia, diagnóstico y tratamiento. Contenidos: en Colombia, la prevalencia de neuropatía periférica se estima en alrededor del 10?%, sin embargo, no hay datos recientes. Dentro de las etiologías más frecuentes se encuentran la neuropatía diabética, infecciosas, inflamatorias, carenciales, toxicas y farmacológicas. Se recomiendan las siguientes herramientas de tamizaje en población de riesgo: DN4, MNSI, test de monofilamento, test de vibración y valoración de reflejos. Las vitaminas B1, B6 y B12 son seguras, accesibles y pueden ser eficaces en neuropatía periférica, incluso cuando el déficit no ha sido demostrado, pero con requerimientos particulares en su administración conjunta. Conclusiones: las neuropatías periféricas son un reto diagnóstico y terapéutico que requiere la identificación oportuna para el tratamiento de la etiología subyacente y el control de síntomas. El uso de vitaminas B neurotrópicas es efectivo y seguro en neuropatía periférica carencial, y también parece ser eficaz en el manejo de neuropatías periféricas de diferentes etiologías.

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Effects of Formulation Variables and Storage Conditions on Light Protected Vitamin B12 Mixed Parenteral Formulations

Cited by 15 publications

References 15 publications

Vitamin B12 in Foods, Food Supplements, and Medicines—A Review of Its Role and Properties with a Focus on Its Stability

Vitamin B12 in Foods, Food Supplements, and Medicines—A Review of Its Role and Properties with a Focus on Its Stability

A Synthesis Review of Vitamins Involved in the Fight against Covid‐19

Vitaminas B neurotrópicas y neuropatía periférica: estado del arte y acuerdo de expertos

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