Effects of fluticasone propionate dosage in an experimental model of feline asthma

Abstract

Cats with inflammatory bronchial disease are usually treated with glucocorticoid (GC) drugs to reduce airway inflammation. Inhalant GC delivery can preserve airway effects while systemic effects are minimized. An appropriate dosage regimen for inhaled GC in cats has not been investigated. A blinded, randomized, cross-over study design was used to investigate the ability of three different dosages of the inhalant GC fluticasone propionate delivered by metered dose inhaler to ameliorate eosinophilic airway inflammation in cats with experimentally induced allergic airway inflammation. Further, suppression of the hypothalamic-pituitary-adrenal axis (HPAA) at each dose was assessed. Fluticasone administered at dosages of 44, 110, or 220 microg q 12h reduced airway eosinophilia by 74%, 82%, or 81%, respectively (no difference). None of the dose regimens tested caused HPAA suppression. We conclude that a twice daily dosage of 44 microg fluticasone should be evaluated for the management of cats with naturally occurring inflammatory bronchial disease.

Long‐term follow‐up in dogs with idiopathic eosinophilic bronchopneumopathy treated with inhaled steroid therapy

“…Only one study assessed three different doses in a model of feline asthma and demonstrated that airway inflammation was similarly improved regardless the dose of inhaled fluticasone (Cohn et al . ). Based on this observation and regarding the pharmacokinetic considerations in dogs and humans discussed above, getting a better clinical response by increasing dosage in dogs with EBP appears unlikely.…”

“…2014. In cats, IST is also used for the management of experimental asthma (Cohn et al . 2010 ) and spontaneous chronic bronchial disease (Allerton et al .…”

Inhaled budesonide therapy in cats with naturally occurring chronic bronchial disease (feline asthma and chronic bronchitis)

“…, Cohn et al . ). The uncontrolled character of this study represents a major limitation, as cases were selected retrospectively and iB therapy was the standard treatment regimen for all cats included during the observation period.…”

“…A recent study in cats with experimentally induced asthma evaluating different dosages of iGC showed that airway eosinophilia was reduced in all groups and did not differ significantly when cats received 44, 110 or 220 µg fluticasone twice daily for 3 weeks (Cohn et al . ). Therefore a lower dose of budesonide might also allow for disease control in cats with spontaneous asthma while minimising the effects on the HPAA axis.…”

Correlation of bronchoalveolar eosinophilic percentage with airway responsiveness in cats with chronic bronchial disease

“…, Cohn et al . ). Although aerosol therapy is widely advocated for the treatment of feline asthma (Padrid, , , Ettinger ) studies demonstrating a benefit in clinical cases are lacking.…”