Effects of fermentation products of<i>Cordyceps militaris</i>on growth performance and bone mineralization of broiler chicks

Han, J.C.; Qu, Hongxia; Wang, J.G.; Yan, Yong; Zhang, J.L.; Yang, Linxi; Zhang, M.; Cheng, Yeong-Hsiang

doi:10.1080/09712119.2014.928630

Cited by 19 publications

(16 citation statements)

References 18 publications

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“…Notably, the inclusion of SM improved the growth performance of weaning pigs. This improvement agrees with previous observations showing that the addition of 1, 2, and 10 g/kg SM significantly improved the zootechnical performance of broiler chickens, growing pigs, and Nile tilapia, respectively [ 23 , 24 , 26 ]. This positive effect may be caused by the weaning pigs being able to uptake nutrients more efficiently and maintain their health status, resulting in better growth performance.…”

Section: Discussionsupporting

confidence: 92%

“…Spent mushroom (SM) from C. militaris contains various bioactive compounds such as gamma-oryzanol, cordycepin, adenosine, D-mannitol, and polysaccharides [ 21 , 22 , 23 ]. The use of C. militaris significantly improved growth performance and immunity [ 24 , 25 ], in agreement with a previous study in which Nile tilapia were fed 10 g/kg SM [ 26 ]. The supplementation of 2 g/kg SM in the diet has recently been reported to stimulate immunoglobulin secretion and antioxidant activity in growing pigs [ 22 ].…”

Section: Introductionsupporting

confidence: 89%

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Effect of Spent Mushroom (Cordyceps militaris) on Growth Performance, Immunity, and Intestinal Microflora in Weaning Pigs

Boontiam

Wachirapakorn

Phaengphairee

et al. 2020

Animals

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There are limited published reports regarding the optimal dosage of spent mushroom. This study investigated the effect of various levels of spent mushroom derived from C. militaris as an alternative growth promoter to an in-feed antibiotic on the growth performance, blood profiles, immunoglobulin, inflammation, and microbial count of weaning pigs. A total of 120 pigs (6.63 ± 0.13 kg initial body weight) were blocked by weight and sex in a randomized complete block design. Each treatment had six replicates of four pigs each. The pigs were allotted into five treatments: (1) positive control (PC) with 150 mg/kg colistin; (2) negative control (NC) without antibiotic inclusion; and (3–5) negative control groups with 0.5, 1.0, and 1.5 g/kg of C. militariss pent mushroom (SM), respectively. Blood samples were collected at day 35 for determination of blood-related lipid metabolism and immunity. Fresh fecal samples were collected to examine microbial counts on day 35 postweaning. The results showed that SM at 1.5 g/kg improved the body weight, average daily weight gain, and average daily feed intake of weaning pigs in the overall period (p < 0.05). Moreover, the highest dosage of SM caused improvements in the concentrations of high-density lipoprotein, and immunoglobulin A, along with suppressions of total cholesterol, interleukin-1, tumor necrosis factor-α, and E. coli (p < 0.05). Therefore, the weaned pigs fed a 1.5 g/kg SM diet showed improved growth performance and displayed greater immunoglobulin secretion and lower inflammation, pathogenic population, and cholesterol concentration.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionsupporting

confidence: 89%

Effect of Spent Mushroom (Cordyceps militaris) on Growth Performance, Immunity, and Intestinal Microflora in Weaning Pigs

Boontiam

Wachirapakorn

Phaengphairee

et al. 2020

Animals

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“…Furthermore, many studies have reported that Cordyceps substances and active ingredients have the ability to improve growth performance and antioxidant function. The improvement of growth performance in broiler chicks (18) and laying hens (19) after feeding with fermentation products and the by-product of Cordyceps militaris, and the enhancement of BW and feed conversion rate of white shrimp (20) after supplementing with Cordyceps polysaccharides suggest that Cordyceps substances and active ingredients are effective in applications for animal husbandry. Additionally, our previous study showed that ATC supplementations accelerated the BW gain of calves, increased the BW and feed efficiency, and improved antioxidant and immune functions (7), which are results similar to those of the current study.…”

Section: Discussionmentioning

confidence: 99%

Acremonium terricola culture plays anti-inflammatory and antioxidant roles by modulating MAPK signaling pathways in rats with lipopolysaccharide-induced mastitis

Jiang

et al. 2020

Food & Nutrition Research

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Background As a major disease affecting dairy cow production worldwide, bovine mastitis is caused by a variety of pathogenic microorganisms that eventually cause mammary gland inflammation. Acremonium terricola culture (ATC) is a new type of affordable feed additive produced by the solid fermentation of A. terricola isolated from Cordyceps gunnii and exerted its anti-inflammatory effect. Objectives To evaluate the protective effects of ATC on mastitis and investigate its active mechanism, a lipopolysaccharide (LPS)-induced rat mastitis model was used in two experiments. Design In Experiment 1, a total of 40 female Sprague–Dawley rats were used to determine the optimal supplementary dose of ATC via gavage trial. In Experiment 2, we examined the effects of an optimal dose of ATC on LPS-induced mastitis in rats. Results The results of Experiment 1 showed that administration of ATC improved growth performance and antioxidant functions in the serum and the liver, as well as immunoglobulin A, G, and M levels in rat serum, and it decreased the content of alanine aminotransferase, aspartate aminotransferase, triglyceride, cholesterol, low-density lipoprotein, and serum urea nitrogen in rat serum; a dosage of 250–1,250 mg/kg/day was shown to be high enough to be effective. The results of Experiment 2 indicated that ATC can relieve the inflammatory reaction of mammary glands in rats, and the LPS-induced expression of tumor necrosis factor-α, interleukin-1β, interleukin-6, and inducible nitric oxide synthase significantly decreased after ATC treatment. Moreover, our results demonstrated that ATC markedly enhanced the activity of antioxidase in this rat mastitis model. The results of Western blot analysis revealed that ATC could suppress the expression of toll-like receptor 4, phosphorylation of extracellular signal-regulated kinase, and activity of c-Jun N-terminal kinase in the LPS-stimulated mastitis model. Conclusion Taken together, ATC was shown to exert its anti-inflammatory effect by blocking mitogen-activated protein kinase signaling pathways. These results demonstrate that ATC exerts anti-inflammatory and antioxidant effects in mastitis prevention.

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“…Therefore, it is marketable in western countries as an over-the-counter medicine. Recently, Hana et al (2014) indicated that supplementation of 0.1% fermentation products of Cordyceps militaris (FPCM) could increase the body weight gain of broilers from 22 to 42 days of age. Hence, the addition of 0.2% FPCM significantly increased the tibia calcium content at 21 and 42 days of chicken broilers; therefore, the authors suggested that FPCM had positive effects on the growth performance of broilers.…”

Section: Introductionmentioning

confidence: 99%

Effect of <i>Cordyceps Militaris </i>Waster Medium on Production Performance, Egg Traits and Egg Yolk Cholesterol of Laying Hens

et al. 2015

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Cordyceps militaris waster medium (CMWM) is a by-product of the edible portion of the fruiting body of Cordyceps fungi. This study was conducted to investigate the effects of the CMWM on the production performance, egg quality and egg yolk cholesterol of laying hens. An in vitro study showed that the reducing power of the CMWM extracts increased linearly with its concentration; at a concentration of 4.0 mg/mL, it reached a level of roughly 60% ascorbic acid at 0.5 mg/mL, while inhibition of lipid peroxidation of the CMWM extracts at 15.0 mg/mL reached nearly 50%. Sixty 22-week-old laying hens (Hendrix) were randomly allocated into 4 groups with 5 replicates, 3 birds per replicate. They were fed diets supplemented with the following levels of the CMWM: 0 (control group, corn-soybean meal), 5.0, 10.0, or 20.0 g/kg dried CMWM groups for 12 weeks, respectively. The results revealed that the 20.0 g/kg CMWM group exhibited significantly decreased feed conversion ratio (FCR) and increased egg white weight compared to the control group at 5-8 and 9-12 weeks. The supplemented CMWM groups showed significantly elevated egg mass in comparison to the control group at 5-8 and 9-12 weeks. There were no effects for egg yolk weight, egg shell weight, shell thickness and egg yolk color between the groups. Those groups which were supplemented with 10.0 and 20.0 g/kg dried CMWM showed significantly decreased egg cholesterol compared to the control group at 9-12 weeks. On the basis of these observations, we concluded that CMWM, a by-product of Cordyceps militaris, could be employed as a new feed additive that offers potential benefits for elevating egg mass and producing lower cholesterol eggs by laying hens.

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Effects of fermentation products ofCordyceps militarison growth performance and bone mineralization of broiler chicks

Cited by 19 publications

References 18 publications

Effect of Spent Mushroom (Cordyceps militaris) on Growth Performance, Immunity, and Intestinal Microflora in Weaning Pigs

Effect of Spent Mushroom (Cordyceps militaris) on Growth Performance, Immunity, and Intestinal Microflora in Weaning Pigs

Acremonium terricola culture plays anti-inflammatory and antioxidant roles by modulating MAPK signaling pathways in rats with lipopolysaccharide-induced mastitis

Effect of <i>Cordyceps Militaris </i>Waster Medium on Production Performance, Egg Traits and Egg Yolk Cholesterol of Laying Hens

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