2004
DOI: 10.1159/000078444
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Abstract: Objectives: Opiates, which serve an integral role in anesthesia, suppress immune function, particularly natural killer cell cytotoxicity (NKCC). NK cells play an important role in tumor and metastasis surveillance. We reported that large-dose fentanyl anesthesia induced prolonged suppression of NKCC in patients undergoing abdominal surgery. The immune modulatory effects of opiates may depend on the interaction between dose and time of administration. The present study examined the effects of different doses of… Show more

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Cited by 164 publications
(109 citation statements)
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“…The surgical procedure, which is a necessary and crucial step in the treatment of most solid cancers, has long been suspected to facilitate the metastatic process (1), and numerous mechanisms were implicated. These mechanisms include dissemination of tumor cells during surgery (3), decreased levels of antiangiogenic factors, local and systemic increase in proangiogenic and growth factors (e.g., VEGF) (4), blood loss and transfusion (5,6), anesthetic and analgesic drugs (7)(8)(9), and the suppression of cell-mediated immunity (CMI) (1). Generally, the more extensive the surgical procedure, the more pronounced the paracrine, neuroendocrine, and immunosuppressive effects of surgery (1,10).…”
mentioning
confidence: 99%
“…The surgical procedure, which is a necessary and crucial step in the treatment of most solid cancers, has long been suspected to facilitate the metastatic process (1), and numerous mechanisms were implicated. These mechanisms include dissemination of tumor cells during surgery (3), decreased levels of antiangiogenic factors, local and systemic increase in proangiogenic and growth factors (e.g., VEGF) (4), blood loss and transfusion (5,6), anesthetic and analgesic drugs (7)(8)(9), and the suppression of cell-mediated immunity (CMI) (1). Generally, the more extensive the surgical procedure, the more pronounced the paracrine, neuroendocrine, and immunosuppressive effects of surgery (1,10).…”
mentioning
confidence: 99%
“…This difference may be secondary to the µ3 receptor, which is not bind by synthetic opioids such as fentanyl [119]. Although suppressive effects of fentanyl on NK cell have been reported in animals [120], in humans it has shown that fentanyl increases activity and number of NK cells, and CD8 + cytotoxic T-lymphocytes [121]. However, neither polymorphonuclear cells (PMNC) activity [122] nor cellular adhesion is affected [123].…”
Section: Opioidsmentioning
confidence: 99%
“…Opioids could potentially be associated with a longer survival due to improvements in pain, as higher pain scores in patients with cancer are associated with a shorter survival [17][18][19][20]. The chronic effects of opioids on survival could include effects on cancer growth which might be mediated by direct effects of opioids on host cells (including angiogenesis or actions on immune cells) or cancer cells (including cancer cell development, apoptosis and metastasis) [21][22][23][24][25], Figure 1. Opioids can inhibit components of both innate and adaptive immunity [21,22,26,27], although a recent systematic review of non-surgical patients with cancer did not find any studies which correlated immune function to clinical outcomes (e.g.…”
Section: Introductionmentioning
confidence: 99%