Effects of Fe-YM1504 on iron deficiency anemia in rats

Abstract

Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. It is possible that some strains present in the natural environment possess a higher tolerance to inorganic iron and a higher ability to convert and accumulate iron compared with Saccharomyces cerevisiae wild-type strain. In the present study, the strain no. YM1504, able to grow in an iron-rich environment, was used as a potential organic iron supplement, and its efficacy in alleviating IDA in rats was investigated. Sixty female weanling Sprague-Dawley rats were randomly divided into a normal control group fed with a standard diet and a model group fed with an iron-deficient diet to create the IDA model. After the model was established, IDA rats were further randomly divided into five subgroups: the IDA group, the ferrous sulfate (FeSO4) group and Fe-YM1504 low-, medium- or high-dose groups receiving different concentrations of Fe-YM1504 supplements. Our results showed that Fe-YM1504 has an effective restorative function by returning the hemoglobin (Hb), hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), serum iron (SI), total iron binding capacity (TIBC), serum ferritin (SF), etc. in IDA animals to the normal level. Moreover, malondialdehyde and the enzyme activities of superoxide dismutase and glutathione peroxidase in both plasma and liver homogenate were improved. Finally, compared with the FeSO4 group, the Fe-YM1504 middle-dose was more effective in alleviating IDA and fewer side effects were observed. The present study indicated that iron-enriched strain no. YM1504 might play a significant role in ameliorating IDA rats and might be exploited as a new iron supplement.

Effect of duck egg white peptide‐ferrous chelate on iron bioavailability in vivo and structure characterization

“…However, in contrast to the liver and renal, no significant differences ( P > 0.05) were observed in the spleen coefficients of rats in different iron supplement groups and IDA group. This result was similar with that reported by Zhang et al . which confirmed that iron deficiency had no adverse effect on the spleen weight.…”

“…MCH in all doses of iron supplements showed no significant differences ( P > 0.05) compared with the control group. This result was also observed by Zhang et al . The SI and SF levels in the model group were less than that of the control group ( P < 0.05, Fig.…”

“…Organ coefficient could be used to assess the safety of the drugs . The organ coefficients of rats are presented in Table .…”

“…Organ coefficient could be used to assess the safety of the drugs. 31 The organ coefficients of rats are presented in Table 3. It was observed that the relative weights of the renal and liver for IDA group were higher (P < 0.05) than those of control group.…”

Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression

“…Serum total iron binding capacity (TIBC) was determined using commercially available kits (Nanjing Jiancheng Bioengineering Institute, Nanjing, China). 30 The limit of detection of this kit was 0.05 mg L À1 .…”