Effects of exercise on sleep in neurodegenerative disease

Memon, Amanullah; Coleman, Juliana; Amara, Amy W.

doi:10.1016/j.nbd.2020.104859

Cited by 45 publications

(37 citation statements)

References 131 publications

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“…A congeries of studies have supported the role of exercise in the therapeutic effects of neurological diseases, such as stroke, Parkinson's disease, and Alzheimer's disease ( 29 , 30 ). Moreover, gut microbiota may play a key role in modulating the oxidative stress and inflammatory responses during endurance exercise ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota

et al. 2021

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Exercise therapy including endurance training and resistance training is a promising non-pharmacological therapy in patients with multiple sclerosis (MS). Recent studies have revealed that exercise exerts beneficial impacts on gut microbiota. However, the role of gut microbiota in the immune benefits of strength exercise (SE; one of resistance training) in central nervous system (CNS) autoimmunity is barely known. Here, we observed that 60-min SE ameliorated disease severity and neuropathology in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. SE increased the abundance and diversity of the gut microbiota, and decreased Firmicutes/Bacteroidetes ratio (F/B ratio) and intestinal mucosal permeability, and enrichment of several short-chain fatty acid (SCFA)-producing bacteria. Furthermore, SE reduced Th17 responses and increased Treg responses in the small intestine lymphoid tissues. Compared to the control group, microbiota-depleted mice receiving SE microbiome fecal transplants had lower disease severity and neuropathology scores. These results uncovered a protective role of SE in neuroimmunomodulation effects partly via changes to the gut microbiome.

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Section: Discussionmentioning

confidence: 99%

Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota

et al. 2021

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“…In a literature review of the effects of exercise on sleep in neurodegenerative diseases, Memon et al identified several studies that show the promising effects of exercise on the disruptive sleep symptoms associated with PD. 27 One study examined a group of 89 patients with PD who completed a 4 week multidisciplinary intensive rehabilitation treatment in the inpatient setting. The treatment consisted of a variety of exercises including aerobic exercise, stretching, occupational therapy and other interventions.…”

Section: Methodsmentioning

confidence: 99%

“…Patients in the exercise group showed significant improvement in PDSS scores in all areas except for two, hallucinations and daytime sleepiness, which were both in normal ranges prior to the intervention when compared to patients in the control group who received no therapy. 27…”

Section: Methodsmentioning

confidence: 99%

“…Another study measuring sleep quality improvement in PD patients compared 2 groups, with an exercise group of 23 participants and a non-exercise control group of 19. 27 The exercise group received moderate intensity aerobic exercise for 1 hour a day, 3 times per week for 6 months. The exercise group demonstrated significant improvement as measured by the Brazilian Mini-Sleep Questionnaire while the control group showed no changes.…”

Section: Methodsmentioning

confidence: 99%

“…The exercise group demonstrated significant improvement as measured by the Brazilian Mini-Sleep Questionnaire while the control group showed no changes. 27 A similar study compared changes in sleep quality in PD patients who completed either 30 minute walking sessions for 6 months or who underwent 4 instructor-led sessions of Qigong for 45 minutes each, followed by 4 times weekly home-based Qigong sessions lasting 20 minutes. 27 Participants who were allocated to the Qigong group reported significant improvement on their PDSS where the walking group reported no changes.…”

Section: Methodsmentioning

confidence: 99%

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The Role of Exercise in Parkinson’s Disease

Emig

George

Zhang

et al. 2021

J Geriatr Psychiatry Neurol

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Parkinson’s disease (PD) is a progressive, neurodegenerative disorder of the central nervous system. While it primarily affects motor function, patients eventually develop non-motor symptoms including depression, anxiety, and eventually dementia. Although there is currently no cure, treatment is aimed largely at improving quality of life though medication or surgical techniques to reduce motor symptoms. However, there is vast evidence of the benefits of physical activity as adjunct therapy for Parkinson’s disease. In this review, we analyze 31 studies or reviews and highlight the role of exercise and rehabilitation in PD treatment. This study serves to provide clinicians with a comprehensive resource of the wide variety of exercises with proven benefit for patients affected by Parkinson’s disease. Specifically, patients report significant improvements in motor function, cognition, mood and sleep habits.

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Glymphatic pathway: An emerging perspective in the pathophysiology of neurodegenerative diseases

Rehman,

Sehar,

Rasool

et al. 2024

Int J Geriat Psychiatry

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The central nervous system (CNS) is widely recognized as the only organ system without lymphatic capillaries to promote the removal of interstitial metabolic by‐products. Thus, the newly identified glymphatic system which provides a pseudolymphatic activity in the nervous system has been focus of latest research in neurosciences. Also, findings reported that, sleep stimulates the elimination actions of glymphatic system and is linked to normal brain homeostatis. The CNS is cleared of potentially hazardous compounds via the glymphatic system, particularly during sleep. Any age‐related alterations in brain functioning and pathophysiology of various neurodegenerative illnesses indicates the disturbance of the brain's glymphatic system. In this context, β‐amyloid as well as tau leaves the CNS through the glymphatic system, it's functioning and CSF discharge markedly altered in elderly brains as per many findings. Thus, glymphatic failure may have a potential mechanism which may be therapeutically targetable in several neurodegenerative and age‐associated cognitive diseases. Therefore, there is an urge to focus for more research into the connection among glymphatic system and several potential brain related diseases. Here, in our current review paper, we reviewed current research on the glymphatic system's involvement in a number of prevalent neurodegenerative and neuropsychiatric diseases and, we also discussed several therapeutic approaches, diet and life style modifications which might be used to acquire a more thorough performance and purpose of the glymphatic system to decipher novel prospects for clinical applicability for the management of these diseases.

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Effects of exercise on sleep in neurodegenerative disease

Cited by 45 publications

References 131 publications

Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota

Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota

The Role of Exercise in Parkinson’s Disease

Glymphatic pathway: An emerging perspective in the pathophysiology of neurodegenerative diseases

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