Effects of ethanol extract of Annona muricata on pentylenetetrazol‐induced convulsive seizures in mice

Anxiolytic-like actions of the hexane extract from leaves of Annona cherimolia in two anxiety paradigms: Possible involvement of the GABA/benzodiazepine receptor complex

“…The presence of the isoquinoline-type alkaloids annonaine, nornuciferine and asimilobine in A. muricata accounted for this activity (Hasrat et al, 1997b). In addition, it has been reported that the ethanol extract of leaves of A. muricata and Annona diversifolia possess anticonvulsant activity in mice (N'Gouemo et al, 1997;González-Trujano et al, 1998). Interestingly, the effect of A. diversifolia was due to palmitone (16-hentriacontanone) a lipoid ketone (González-Trujano et al, 2001).…”

Annona muricata (Graviola) (Annonaceae): Phytochemistry, Pharmacology and Future Directions, a Review

“…The results showed that the plant extract significantly reduced the incidence of tonic PTZ seizures and mortality, and prolonged the time to onset of PTZ clonic seizures. This study indicates that the extract of A. muricata leaves contains at least one or more active substances that preferentially suppress the tonic phase of PTZ-induced clonic seizures [218].…”

Role of plants, environmental toxins and physical neurotoxicological factors in Amyotrophic lateral sclerosis, Alzheimer Disease and other Neurodegenerative Diseases

“…The results demonstrated that the plant extract signi icantly reduced the incidence of tonic PTZ seizures and mortality, and lengthened the onset to clonic PTZ seizures. This indicates that extract of the leaves of A. muricata contains active substance(s) that preferentially suppressed the tonic phase of PTZ-induced clonic-tonic seizures" [6].…”