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Cited by 50 publications
(42 citation statements)
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References 36 publications
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“…In a previous 28-d study, we demonstrated effects on growth in early life stage (ELS) medaka following exposure to environmentally relevant concentrations of metformin (Ussery et al 2018). Therefore, one goal of the present study was to characterize the developmental toxicity of environmentally relevant concentrations of guanylurea on the growth of ELS medaka, as well as to examine the persistence of ELS effects on growth into adulthood.…”
Section: Introductionmentioning
confidence: 98%
“…In a previous 28-d study, we demonstrated effects on growth in early life stage (ELS) medaka following exposure to environmentally relevant concentrations of metformin (Ussery et al 2018). Therefore, one goal of the present study was to characterize the developmental toxicity of environmentally relevant concentrations of guanylurea on the growth of ELS medaka, as well as to examine the persistence of ELS effects on growth into adulthood.…”
Section: Introductionmentioning
confidence: 98%
“…Metformin, the parent compound of guanylurea, clearly reduced the growth of fish. This was shown for early life stages of Japanese medaka (Ussery et al 2018), but also for brown trout (Jacob et al 2018) and adult male fathead minnow in a full life cycle test . This metformin-induced effect might be explained by the appetite reducing capacity of metformin which also explains its use as a weight loss drug (Malin & Kashyap 2014).…”
Section: Discussionmentioning
confidence: 59%
“…Metformin, the parent compound of guanylurea, clearly reduced the growth of fish. This was shown for early life stages of Japanese medaka (Ussery et al, 2018), but also for brown trout (Jacob et al, 2018) and adult male fathead minnows in a full life cycle test (Niemuth & Klaper, 2015). This metformin-induced effect might be explained by the appetite reducing capacity of metformin, which also explains its use as a weight loss drug (Malin & Kashyap, 2014).…”
Section: Discussionmentioning
confidence: 83%