Effects of environmental enrichment and social isolation on sucrose consumption and preference: Associations with depressive-like behavior and ventral striatum dopamine

Brenes, Juan C.; Fornaguera, Jaime

doi:10.1016/j.neulet.2008.03.045

Cited by 84 publications

(73 citation statements)

References 30 publications

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“…Our finding is consistent with previous results showing that the enriched environments decreased the response to amphetamine-induced stress-related behaviors such as anxiety [12,29], and depressive-like behaviors [4]. Presently, the neurobiological mechanisms underlying the reduced anxiety and depression following enriched environment are still not known.…”

Section: Discussionsupporting

confidence: 93%

“…Presently, the neurobiological mechanisms underlying the reduced anxiety and depression following enriched environment are still not known. It may be due to direct and indirect involvement of a variety of neurotransmitter system including serotonin [4], norepinephrine [10], BDNF [15] and D2 receptor availability [23] in the various regions of brain following enriched environment. Therefore, the enriched environment was able to promote functional recovery in neurotransmitter systems involved in anxiety and depression.…”

Section: Discussionmentioning

confidence: 99%

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Effect of the environmental enrichment on the severity of psychological dependence and voluntary methamphetamine consumption in methamphetamine withdrawn rats

Hajheidari

Miladi‐Gorji

Bigdeli

2015

Neuroscience Letters

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Effect of the environmental enrichment on the severity of psychological dependence and voluntary methamphetamine consumption in methamphetamine withdrawn rats

Hajheidari

Miladi‐Gorji

Bigdeli

2015

Neuroscience Letters

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“…This viewpoint is also supported by animal studies showing that MD but not CUPS induce severe anhedonia in rats (Bai, Zhang, et al., 2014). MD and CUPS also exert dissimilar effects on the expression of D1, D2‐like receptors, and DAT in some of the mesocorticolimbic dopaminergic pathways (Bassareo, De Luca, & Di Chiara, 2007; Brenes & Fornaguera, 2008). In this study, we first demonstrated that different depressive behaviors of rats such as anhedonia, passive coping behavior, and exploratory interest may be related to divergent dopaminergic pathways.…”

Section: Discussionmentioning

confidence: 99%

Divergent anomaly in mesocorticolimbic dopaminergic circuits might be associated with different depressive behaviors, an animal study

et al. 2017

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BackgroundThe mesocorticolimbic dopamine system, which originates from the ventral tegmental area (VTA) and projects primarily to the prefrontal cortex (PFC), olfactory tubercle (OT), nucleus accumbens (NAc), dorsal striatum (ST), and the amygdala (AMy), plays a pivotal role in determining individual motivation and sensitivity to rewards, namely, anhedonia. Not all depressive individuals exhibited anhedonia, thus, it is natural to speculate that the heterogenous manifestations of depression might be related to the mesocorticolimbic dopamine system. Maternal deprivation (MD) and chronic unpredictable stress (CUPS) are two well‐established depressogenic stressors, and they were proven to induce different depressive phenotypes.MethodsThe depressive and anxiety‐like behaviors of MD and CUPS‐treated rats were measured by classical behavioral tests including open field, forced swimming, and sucrose preference test. The expression of D1‐5 dopamine receptors and DAT mRNA and protein in the mesocorticolimbic dopamine system of rats exposed to MD and CUPS were measured by real‐time PCR and Western blot, respectively.ResultsSevere anhedonia was observed in MD but not CUPS rats. Divergent expression of D1 and D2 receptors and DAT mRNA and protein in the mesocorticolimbic dopamine system were found between MD and CUPS rats. Significant correlations between different depressive behaviors and D1‐/D2‐like receptors and DAT protein levels in the mesocorticolimbic dopamine system were observed.ConclusionDifferent depressive behaviors of rats such as anhedonia, passive coping behavior, and declined exploratory interest might be related to divergent dopaminergic pathways. Anhedonia is associated with the dysfunction of VTA‐NAc and VTA‐OT dopaminergic pathways, the passive coping behavior is related to the dysregulation of VTA‐PFC and VTA‐AMy pathways, and individual exploratory interest is associated with abnormal activity of VTA‐PFC and VTA‐ST pathways.

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“…There is consolidated evidence to show that the characteristics of the housing environment have a marked influence on the behaviour and welfare of animals, both those raised for biomedical investigation or farm animals (Beattie et al, 2000;Olsen et al, 2002;Laviola et al, 2004;Dong et al, 2007;Brenes et al, 2008). In particular, the provision of straw seems to represent a suitable strategy to alleviate the presence of injurious behaviours in swine (Petersen et al, 1995;Kelly et al, 2000;Guy et al, 2002;Van de Weerd et al, 2006;Studnitz et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal effects of environmental enrichment on behaviour and physiology of pigs reared on an intensive-stock farm

Manciocco

Sensi

Moscati

et al. 2011

Italian Journal of Animal Science

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The aim of this paper was to provide a longitudinal evaluation of the effects of physical enrichments on the behaviour and physiology of intensive stock-farming pigs. Twenty-eight crossbred pigs of both sexes, were exposed to four types of enrichments (hemp ropes, steel chains, plastic balls, rubber hoses) over a period of eleven weeks. This investigation was based on specific abnormal behaviours and physiological indicators, including hematologic parameters. For behavioural score, focal sampling was used with recording of abnormal behaviours (body-, tail-and ear-biting), belly nosing, running, and interaction with objects (for Enriched pigs). The presence of skin injuries was also recorded. In general, the frequency of abnormal behaviours was significantly reduced in the Enriched group. A timerelated profile appeared in the use of the enrichments. Males showed higher occurrence of skin injuries than females. Physiological measurements, such as levels of complement system, white blood cells and neutrophils, were lower in pigs from the Enriched group.Enriched pigs, as a whole, presented much lower levels of serum DHEA-S concentration over two weeks. The findings of this study show the successful provision of appropriate enrichments to encourage behaviours which may result in satisfactory animal oral interaction with the enriching objects, preventing them biting pen-mates. In this respect, the objects proposed were strongly effective in producing changes in behaviour which could mitigate inadequate conditions, such as the relationship between animal body weight and the available space allowance.

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Effects of environmental enrichment and social isolation on sucrose consumption and preference: Associations with depressive-like behavior and ventral striatum dopamine

Cited by 84 publications

References 30 publications

Effect of the environmental enrichment on the severity of psychological dependence and voluntary methamphetamine consumption in methamphetamine withdrawn rats

Effect of the environmental enrichment on the severity of psychological dependence and voluntary methamphetamine consumption in methamphetamine withdrawn rats

Divergent anomaly in mesocorticolimbic dopaminergic circuits might be associated with different depressive behaviors, an animal study

Longitudinal effects of environmental enrichment on behaviour and physiology of pigs reared on an intensive-stock farm

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