Effects of Endotracheal Epinephrine on Pharmacokinetics and Survival in a Swine Pediatric Cardiac Arrest Model
Don Johnson,
Julie G. Hensler,
Joseph O'Sullivan
et al.
Abstract:Objectives
The aim of this study was to compare the endotracheal tube (ET) and intravenous (IV) administration of epinephrine relative to concentration maximum, time to maximum concentration, mean concentration over time (MC), area under the curve, odds, and time to return of spontaneous circulation (ROSC) in a normovolemic pediatric cardiac arrest model.
Methods
Male swine weighing 24–37 kg were assigned to 4 groups: ET (n = 8), IV (n = 7), cardiopulmo… Show more
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