Effects of enalapril on vasoactive intestinal peptide metabolism and tissue levels

Duggan, Karen; Ye, Victor Z. C.

doi:10.1016/s0014-2999(98)00583-4

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…The conclusion that VIP has a more important function in the right atrium than in the left ventricle is also supported by previous studies on mammalian cardiac tissue, showing more dense innervation with VIP-immunoreactive nerve fibres in the atriae than in the left ventricle [1,8,26]. From an interesting clinical point of view, it has been proposed that the increased cardiac output seen during treatment with angiotensin-converting enzyme (ACE) inhibitors may be due in part to increased cardiac levels of VIP [34]. Given that atrial contraction is particularly important in order to maintain cardiac output and exercise performance under critical conditions, increased responsiveness of the atria to positive inotropic agents may serve a physiological purpose under such conditions [33].…”

Section: Discussionsupporting

confidence: 53%

Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae

Opgaard¹,

Knutsson²,

Vries³

et al. 2001

Clinical Science

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The aim of the present study was to assess the inotropic effects of vasoactive intestinal peptide (VIP) on isolated myocardial trabeculae from the right atrium and the left ventricle of human hearts. Furthermore, using reverse transcriptase-PCR, we wanted to determine the presence of mRNAs encoding the three cloned human VIP receptors, VPAC(1), VPAC(2) and PAC(1). The trabeculae were paced at 1.0 Hz in tissue baths, and changes in isometric contractile force upon exposure to agonist were studied. VIP had a potent positive inotropic effect in some of the atrial and ventricular trabeculae tested. This effect was almost completely blocked by the VIP-receptor antagonist VIP-(6-28). mRNAs encoding the human VPAC(1), VPAC(2) and PAC(1) receptors were detected in human myocardial trabeculae from both the right atrium and the left ventricle. In conclusion, VIP has a direct positive inotropic effect in both the atria and the ventricles of the human heart. The presence of mRNAs for the VPAC(1), VPAC(2) and PAC(1) receptors suggest that VIP may mediate its effect via these receptors.

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Section: Discussionsupporting

confidence: 53%

Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae

Opgaard¹,

Knutsson²,

Vries³

et al. 2001

Clinical Science

View full text Add to dashboard Cite

show abstract

“…Given that atrial contraction is particularly important in order to maintain cardiac output and exercise performance under critical conditions, increased responsiveness of the atria to positive inotropic agents may serve a physiological purpose under such conditions [33]. From an interesting clinical point of view, it has been proposed that the increased cardiac output seen during treatment with angiotensin-converting enzyme (ACE) inhibitors may be due in part to increased cardiac levels of VIP [34].…”

Section: Discussionmentioning

confidence: 99%

Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae

et al. 2001

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A B S T R A C TThe aim of the present study was to assess the inotropic effects of vasoactive intestinal peptide (VIP) on isolated myocardial trabeculae from the right atrium and the left ventricle of human hearts. Furthermore, using reverse transcriptase-PCR, we wanted to determine the presence of mRNAs encoding the three cloned human VIP receptors, VPAC 1 , VPAC 2 and PAC 1 . The trabeculae were paced at 1.0 Hz in tissue baths, and changes in isometric contractile force upon exposure to agonist were studied. VIP had a potent positive inotropic effect in some of the atrial and ventricular trabeculae tested. This effect was almost completely blocked by the VIP-receptor antagonist VIP-(6-28). mRNAs encoding the human VPAC 1 , VPAC 2 and PAC 1 receptors were detected in human myocardial trabeculae from both the right atrium and the left ventricle. In conclusion, VIP has a direct positive inotropic effect in both the atria and the ventricles of the human heart. The presence of mRNAs for the VPAC 1 , VPAC 2 and PAC 1 receptors suggest that VIP may mediate its effect via these receptors.

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“…1996 ) around the small cerebral vessels suggests that these peptides have roles in the regulation of the cerebral circulation. The plasma concentration of VIP ( Duggan & Ye 1998) is in the picomolar range (in the literature there are no data concerning the plasma concentration of PACAP, but presumably its concentration in the same range as VIP), but the concentration of the neuropeptides can be much more higher at the site of the release (e.g. around the microvessels).…”

Section: Discussionmentioning

confidence: 99%

Pituitary adenylate cyclase‐activating polypeptide inhibits the cyclooxygenase pathway of rat cerebral microvessels

Kis

Gáspár

Mezei

et al. 1999

Acta Physiologica Scandinavica

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The presence of nerve endings containing pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) around cerebral microvessels suggests that these peptides have regulatory roles in the cerebral microcirculation. Prostanoids synthesized by the cerebrovascular endothelium have a determining role in the regulation of the brain circulation. In the present study, the effects of PACAP and VIP on the cyclooxygenase pathway of cerebral microvessels were investigated. The isolated microvessels were incubated with 1-14C-arachidonic acid and different concentrations of the peptides. The prostanoids formed were separated by means of overpressure thin-layer chromatography, and were quantitatively determined by liquid scintillation. Higher concentrations (10-7 and 10-6 mol L-1) of PACAP significantly inhibited the activity of the cyclooxygenase pathway, whereas VIP had no significant effect on it. As regards the cyclooxygenase metabolites, the syntheses of thromboxane A2 and prostaglandin D2 were inhibited significantly. PACAP and VIP are known to increase the intracellular cAMP level in the cerebral microvessels and in the present experiments the protein kinase A inhibitor H-89 attenuated the effect of PACAP on prostanoid synthesis. It is concluded that the cyclooxygenase pathway of rat cerebral microvessels is more sensitive to PACAP than to VIP. The inhibitory effect of PACAP on prostanoid synthesis is mediated via a cAMP-dependent pathway. By inhibiting the formation of vasoactive prostanoids, PACAP can decrease the vasoreactivity of the microvessels.

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Effects of enalapril on vasoactive intestinal peptide metabolism and tissue levels

Cited by 6 publications

References 31 publications

Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae

Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae

Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae

Pituitary adenylate cyclase‐activating polypeptide inhibits the cyclooxygenase pathway of rat cerebral microvessels

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