2015
DOI: 10.1016/j.chom.2015.03.006
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Abstract: SUMMARY Circadian clocks and metabolism are inextricably intertwined, where central and hepatic circadian clocks coordinate metabolic events in response to light-dark and sleep-wake cycles. We reveal an additional key element involved in maintaining host circadian rhythms, the gut microbiome. Despite persistence of light-dark signals, germ-free mice fed low or high fat diets exhibit markedly impaired central and hepatic circadian clock gene expression and do not gain weight compared to conventionally-raised co… Show more

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Cited by 639 publications
(740 citation statements)
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References 40 publications
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“…Indeed, the SCFA propionate could regulate sympathetic nervous system activity in the sympathetic ganglion via Gpr41, 43 and metabolites produced by the gut microbiota have been linked to the regulation of central circadian rhythm. 44 This is consistent with our findings that support a role for fiber and acetate in the regulation of circadian cycle in both the kidney and heart. Our data also showed that fiber and acetate significantly increased the abundance of the bacteria Bacteroides acidifaciens.…”
Section: Cardiac Transcriptomesupporting
confidence: 93%
“…Indeed, the SCFA propionate could regulate sympathetic nervous system activity in the sympathetic ganglion via Gpr41, 43 and metabolites produced by the gut microbiota have been linked to the regulation of central circadian rhythm. 44 This is consistent with our findings that support a role for fiber and acetate in the regulation of circadian cycle in both the kidney and heart. Our data also showed that fiber and acetate significantly increased the abundance of the bacteria Bacteroides acidifaciens.…”
Section: Cardiac Transcriptomesupporting
confidence: 93%
“…As mentioned above, the gut microbiota is affected by host exercise level, and changes in the microbiota appear to mediate some of the beneficial effects of exercise on host physiology (Mika and Fleshner, 2016). Microbially derived metabolites can also regulate central and hepatic circadian clocks of the host (Leone et al, 2015).…”
Section: Resident (Or Indigenous) Microbesmentioning
confidence: 99%
“…Our physiology is closely tied to our circadian rhythms O the physical, mental, and behavioural changes that follow a roughly 24-h, light-dark cycle. This cycle organizes whole-body energy homeostasis, including energy intake, fat accumulation, caloric expenditure, and even regulates the gut microbiota living within our intestines (Leone et al 2015). Insufficient, short, or disturbed sleep O as happens with shift work O alter the body's hunger and satiety signals, which results in variation in the timing and amount of food consumed.…”
Section: Extended Work Schedules Irregular Work and Shiftwork: Impamentioning
confidence: 99%