Effects of Diphenylhydantoin Sodium (Dilantin Sodium) and Phenobarbital Sodium Upon Ectopic Ventricular Tachycardia in Acute Myocardial Infarction

Harris, Andrew; Kokernot, R. H.

doi:10.1152/ajplegacy.1950.163.3.505

Cited by 132 publications

(29 citation statements)

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“…The possible similarity between cerebral impulses in epilepsy and ectopic activity in myocardial infarction was noted by Harris & Kokernot (1950) who were able to demonstrate an antiarrhythmic effect of the antiepileptic agent, phenytoin (diphenylhydantoin). Subsequently, phenytoin has been proved to be effective in correcting various experimental and clinical arrhythmias (see review by Dreifus & Watanabe, 1970) and has gained wide clinical use.…”

Section: Introductionmentioning

confidence: 90%

Investigation of the Antifibrillatory Activity of Some Anticonvulsant Γ‐aminobutyric Acid‐transaminase Inhibitors in the Rabbit Isolated Heart: Comparison With Phenytoin and Mexiletine

Almotrefi

Baker

1980

British J Pharmacology

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IThe electrical stimulation and ventricular fibrillation thresholds were measured in the Langendorff-perfused rabbit heart by application of rectangular impulses of 3 ms duration and increasing current at frequencies of 4 and 20 Hz respectively. 2 Perfusion with either phenytoin or mexiletine produced significant dose-dependent increases in both thresholds.3 Perfusion with four anticonvulsant inhibitors of y-aminobutyric acid (GABA-transaminase, aminooxyacetic acid, y-acetylenic GABA, y-vinyl GABA and sodium valproate, up to a concentration of 20 pg/ml, had no significant effect on either threshold.4 The results suggest that these compounds, unlike phenytoin and mexiletine, are devoid of antifibrillatory activity.

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Section: Introductionmentioning

confidence: 90%

Investigation of the Antifibrillatory Activity of Some Anticonvulsant Γ‐aminobutyric Acid‐transaminase Inhibitors in the Rabbit Isolated Heart: Comparison With Phenytoin and Mexiletine

Almotrefi

Baker

1980

British J Pharmacology

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“…From Withering's administration of a decoction of foxglove to his patients [8] through clinical use of quinidine, procaine and diphenylhydantoin in the first half of the twentieth century [9,10] antiarrhythmic drug therapy was largely empirical. Singh and Vaughan Williams made the first widely accepted attempt to develop antiarrhythmic strategies based on an understanding of mechanism [11], defining drug actions largely via their electrophysiologic effects on isolated tissues.…”

Section: The Status Of Drug and Device Therapies: From Empirical To Mmentioning

confidence: 99%

Regenerative therapies in electrophysiology and pacing

Rosen

Brink

Cohen

et al. 2008

J Interv Card Electrophysiol

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The prevention and treatment of cardiac arrhythmias conferring major morbidity and mortality is far from optimal, and relies heavily on devices and drugs for the partial successes that have been seen. The greatest success has been in the use of electronic pacemakers to drive the hearts of patients having high degree heart block. Recent years have seen the beginnings of attempts to use novel approaches available through gene and cell therapies to treat both brady-and tachyarrhythmias. By far the most successful approaches to date have been seen in the development of biological pacemakers. However, the far more difficult problems posed by atrial fibrillation and ventricular tachycardia are now being addressed. In the following pages we review the approaches now in progress as well as the specific methodologic demands that must be met if these therapies are to be successful.

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“…This information is of some importance since it is known that 61% of electrical deaths arising from myocardial infarction among patients younger than 65 occur within one hour of onset (Gordon & Kannel, 1971 (Schone & Lindner, 1962). This effectively reduces cardiac sympathetic drive which has been implicated in the genesis of early arrhythmias induced either by coronary ligation (Harris, Estandia & Tillotson, 1951;Harris & Bisteni, 1955;Shanks & Dunlop, 1967) or by infusion of cardiac glycosides (Dohadwalla et al, 1969). Secondly, prenylamine causes direct effects on various phases of the cardiac action potential.…”

Section: Anaesthetized Guinea-pigsmentioning

confidence: 99%

The Haemodynamic and Metabolic Effects of Mg 8926, a Prospective Antidysrhythmic and Antianginal Agent

Marshall

Parratt

1977

British J Pharmacology

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The antidysrhythmic, haemodynamic and metabolic effects of a new prospective antianginal and antidysrhythmic agent, N-(3,3-diphenylpropyl)-a-methyl-/B-cyclohexylethylamine hydrochloride (MG 8926), have been compared with the chemically related substance, prenylamine, in anaesthetized greyhounds and guinea-pigs. 2 When given intravenously 20 min beforehand, both MG 8926 and prenylamine (5 mg/kg) significantly suppressed the early dysrhythmias induced by coronary artery ligation in anaesthetized greyhounds. At a dose of 1 mg/kg, MG 8926 also protected anaesthetized guinea-pigs from dysrhythmias induced by ouabain infusions. 3 In dogs pretreated with MG 8926, metabolic changes indicative of myocardial ischaemia (increased Pco2 and potassium efflux, decreased oxygen content and pH) were less marked than those occurring in control animals. 4 Evidence was obtained that MG 8926, when given either before or after coronary occlusion, was capable of decreasing the severity of myocardial ischaemia as assessed by ST-segment changes in epicardial electrocardiograms.

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Effects of Diphenylhydantoin Sodium (Dilantin Sodium) and Phenobarbital Sodium Upon Ectopic Ventricular Tachycardia in Acute Myocardial Infarction

Cited by 132 publications

References 0 publications

Investigation of the Antifibrillatory Activity of Some Anticonvulsant Γ‐aminobutyric Acid‐transaminase Inhibitors in the Rabbit Isolated Heart: Comparison With Phenytoin and Mexiletine

Investigation of the Antifibrillatory Activity of Some Anticonvulsant Γ‐aminobutyric Acid‐transaminase Inhibitors in the Rabbit Isolated Heart: Comparison With Phenytoin and Mexiletine

Regenerative therapies in electrophysiology and pacing

The Haemodynamic and Metabolic Effects of Mg 8926, a Prospective Antidysrhythmic and Antianginal Agent

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