Effects of different types of stress on histamine-H3 receptors in the rat cortex

Ghi, Piera; Ferretti, Carlo; Blengio, M.

doi:10.1016/0006-8993(95)00542-x

Cited by 16 publications

(13 citation statements)

References 23 publications

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“…The possible involvement of H 3 R function in depression has been described previously 10,11. Lamberti et al found that the highly selective H 1 R agonist 2-(3-trifluoromethylphenyl) histamine, the better known H 1 R agonist 2-thiazolylethylamine, and the standard H 3 R antagonist/inverse agonist thioperamide had antidepressant-like activity in the mouse forced swim test (FST) 12.…”

Section: Introductionmentioning

confidence: 85%

Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283

Bahí¹,

Schwed²,

Walter³

et al. 2014

DDDT

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Previous studies have suggested a potential link between histamine H3 receptors (H3R) signaling and anxiolytic-like and antidepressant-like effects. The aim of this study was to investigate the acute effects of ST-1283, a novel H3R antagonist, on anxiety-related and depression-related behaviors in comparison with those of diazepam and fluoxetine. The effects of ST-1283 were evaluated using the elevated plus maze test, open field test, marbles burying test, tail suspension test, novelty suppressed feeding test, and forced swim test in male C57BL/6 mice. The results showed that, like diazepam, ST-1283 (7.5 mg/kg) significantly modified all the parameters observed in the elevated plus maze test. In addition, ST-1283 significantly increased the amount of time spent in the center of the arena without altering general motor activity in the open field test. In the same vein, ST-1283 reduced the number of buried marbles as well as time spent digging in the marbles burying test. The tail suspension test and forced swim test showed that ST-1283 was able to reduce immobility time, like the recognized antidepressant drug fluoxetine. In the novelty suppressed feeding test, treatment with ST-1283 decreased latency to feed with no effect on food intake in the home cage. Importantly, pretreatment with the H3R agonist R-α-methylhistamine abrogated the anxiolytic and antidepressant effects of ST-1283. Taken together, the present series of studies demonstrates the novel effects of this newly synthesized H3R antagonist in a number of preclinical models of psychiatric disorders and highlights the histaminergic system as a potential therapeutic target for the treatment of anxiety-related and depression-related disorders.

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Section: Introductionmentioning

confidence: 85%

Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283

Bahí¹,

Schwed²,

Walter³

et al. 2014

DDDT

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“…CMS is a naturalistic paradigm of a hostile environment which models anhedonia, a core symptom of depression defined as the diminished preference by rats for palatable sweetened solution (sucrose solution) in a free choice trial with water. The animal model of anhedonia has proven to be especially successful in the functional identification of antidepressant drugs and, therefore, has a high degree of predictive validity Ghi et al, 1995;Papp et al, 1996;Przegalinski et al, 1995). It has also been reported by Zurita et al (2000) that early exposure to successive, dissimilar, and unescapable stressors facilitates the occurrence of anhedonia and disturbed emotional reactions when the rats are later exposed to a novel threatening situation.…”

Section: Introductionmentioning

confidence: 99%

Quetiapine Prevents Anhedonia Induced by Acute or Chronic Stress

Orsetti

Canonico

Dellarole

et al. 2007

Neuropsychopharmacol

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The role of atypical antipsychotics as add-on treatments and as primary mood stabilizers in different phases of bipolar disorder is an important current research area. Although in bipolar patients the main therapeutic indication of quetiapine (QTP) is the management of acute mania, several observations suggest that this agent may exert antidepressant as well as antimanic effects. However, in our knowledge, there are no preclinical studies supporting this hypothesis. Thus, the main goal of the present work was to evaluate the putative antidepressant effect of QTP (0.4, 2.0, or 10 mg/kg/day), in comparison to amitriptyline (AMI) (2 or 5 mg/kg/day), in rats exposed to acute or chronic stress. The administration of QTP, 2 mg/kg/day, prevents the onset of anhedonia in rats exposed to a 6-week chronic mild stress (CMS) protocol. The effect of QTP has a slow onset, beginning at week 5, and causes a complete recovery from anhedonia. In this respect, the effect of QTP is similar to that obtained after chronic administration of AMI 2 or 5 mg/kg/day. Our findings also indicate that a 6-week administration of QTP, 2 or 10 mg/kg/day, has protective effects against the onset of anhedonia caused by the exposure to an acute subthreshold stressful event in rats that have previously experienced the CMS procedure. The results suggest that QTP is able to prevent both the transient mood depression caused by acute stress and the long-lasting anhedonic state induced by exposure, over a period of weeks, to a variety of unpredictable mild stressors.

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“…For example, several stress models are commonly used to evoke depression-like symptoms in animals, including restraint (reviewed in (Thiebot et al, 1992)) and chronic mild stress (CMS), a widely used regimen that consists of a schedule of confinement, food/water restriction, novel environment, wet bedding, and overnight cage tilt (Konkle et al, 2003). Furthermore, chronic unpredictable stress has been used to test nociception (Pinto-Ribeiro et al, 2004), gene expression (Qin et al, 2004), and cortical histamine receptor expression (Ghi et al, 1995) in rats; however, different stress paradigms were operationally defined as "chronic unpredictable stress" for each study. The extent to which each of these stressors affects the HPA axis or immune function remains unspecified.…”

Section: Introductionmentioning

confidence: 99%

“…Recent work, however, suggests that different types of stressors may not necessarily elicit parallel biochemical and physiological changes. Specific stressors induce differential physiological responses, including: brain activation patterns (Dayas et al, 2001;Reyes et al, 2003), Fos immunoreactivity (Pacak and Palkovits, 2001), , receptor expression (Ghi et al, 1995), and neurotransmitter release (Pacak, 2000). More specifically, the immune system has been found to be differentially influenced by stressors, particularly in macrophage activity (Palermo-Neto et al, 2003), antibody production (Karp et al, 2000), and sensitivity to the antigen DNFB (Blecha et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

Stressor-specific alterations in corticosterone and immune responses in mice

Bowers

Bilbo

Dhabhar

et al. 2008

Brain, Behavior, and Immunity

197

122

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Different stressors likely elicit different physiological and behavioral responses. Previously reported differences in the effects of stressors on immune function may reflect qualitatively different physiological responses to stressors; alternatively, both large and subtle differences in testing protocols and methods among laboratories may make direct comparisons among studies difficult. Here we examine the effects of chronic stressors on plasma corticosterone concentrations, leukocyte redistribution, and skin delayed-type hypersensitivity (DTH) and the effects of acute stressors on plasma corticosterone and leukocyte redistribution. The effects of several commonly used laboratory stressors including restraint, forced swim, isolation, and low ambient temperatures (4°C) were examined. Exposure to each stressor elevated corticosterone concentrations, with restraint (a putative psychological stressor) evoking a significantly higher glucocorticoid response than other stressors. Chronic restraint and forced swim enhanced the DTH response compared to the handled, low temperature, or isolation conditions. Restraint, low temperature, and isolation significantly increased trafficking of lymphocytes and monocytes compared to forced swim or handling. Generally, acute restraint, low temperature, isolation, and handling increased trafficking of lymphocytes and monocytes. Considered together, our results suggest that the different stressors commonly used in psychoneuroimmunology research may not activate the physiological stress response to the same extent. The variation observed in the measured immune responses may reflect differential glucocorticoid activation, differential metabolic adjustments, or both processes in response to specific stressors.

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Effects of different types of stress on histamine-H3 receptors in the rat cortex

Cited by 16 publications

References 23 publications

Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283

Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283

Quetiapine Prevents Anhedonia Induced by Acute or Chronic Stress

Stressor-specific alterations in corticosterone and immune responses in mice

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