volume 8, issue 12, P3341-3355 2016
DOI: 10.18632/aging.101122
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Daniele Lettieri-Barbato, Esmeralda Giovannetti, Katia Aquilano

Abstract: In developing countries the rise of obesity and obesity-related metabolic disorders, such as cardiovascular diseases and type 2 diabetes, reflects the changes in lifestyle habits and wrong dietary choices. Dietary restriction (DR) regimens have been shown to extend health span and lifespan in many animal models including primates. Identifying biomarkers predictive of clinical benefits of treatment is one of the primary goals of precision medicine. To monitor the clinical outcomes of DR interventions in humans,…

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