2016
DOI: 10.18632/aging.101122
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Abstract: In developing countries the rise of obesity and obesity-related metabolic disorders, such as cardiovascular diseases and type 2 diabetes, reflects the changes in lifestyle habits and wrong dietary choices. Dietary restriction (DR) regimens have been shown to extend health span and lifespan in many animal models including primates. Identifying biomarkers predictive of clinical benefits of treatment is one of the primary goals of precision medicine. To monitor the clinical outcomes of DR interventions in humans,… Show more

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Cited by 47 publications
(25 citation statements)
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“…In line with other studies, Rot did not cause changes in body weight (Inden et al, 2011 ; Liu et al, 2015 ), whereas IF caused about 10% decrease of body weight that was comparable to that observed in Rot/IF-treated mice (Figure 1A ). These findings are in line with previous works revealing the slimming effect of IF (Lettieri-Barbato et al, 2016 ). No alterations in brain weights and other organs, such as liver and heart, were instead observed (data not shown).…”
Section: Resultssupporting
confidence: 94%
“…In line with other studies, Rot did not cause changes in body weight (Inden et al, 2011 ; Liu et al, 2015 ), whereas IF caused about 10% decrease of body weight that was comparable to that observed in Rot/IF-treated mice (Figure 1A ). These findings are in line with previous works revealing the slimming effect of IF (Lettieri-Barbato et al, 2016 ). No alterations in brain weights and other organs, such as liver and heart, were instead observed (data not shown).…”
Section: Resultssupporting
confidence: 94%
“…However, the effect of DR on IGF-1 signaling in humans appears to be more complex. A recent study showed that DR significantly decreased insulin and IGF-1 levels in humans, consistent with observations in rodents [46]. However, DR failed to decrease GH and IGF-1 levels in non-obese men and women [47].…”
Section: Signaling Network Of Foxo In Dr: Insulin/igf-1 Signaling Pasupporting
confidence: 74%
“…Dietary restriction remains one of the most robust methods for lifespan extension and health improvement. Its benefits are widespread, including improved responses in models of cancer (90, 91), neurodegeneration (92), and other age-related disorders (9395). Despite these reported benefits, enthusiasm for DR has been tempered by the observation that model organisms of different genotypes respond differently to DR (32, 77), with some genotypes even showing a reduced lifespan (31) or worsened health (96).…”
Section: Discussionmentioning
confidence: 99%