Effects of dietary butylated hydroxytoluene on functional and biochemical properties of platelets and plasma preceding the occurrence of haemorrhage in rats

Final Report on the Safety Assessment of BHT

“…Plasma triglycerides, diglycerides, and lipid hydroperoxides were signi cantly decreased. A signi cant decrease in plasma zinc concentration was also observed in BHT-treated animals (Takahashi and Hiraga 1984).…”

Final Report on the Safety Assessment of BHT

“…Plasma triglycerides, diglycerides, and lipid hydroperoxides were signi cantly decreased. A signi cant decrease in plasma zinc concentration was also observed in BHT-treated animals (Takahashi and Hiraga 1984).…”

Comparative ameliorative actions of extracted bradykinin potentiating fraction from cobra snake venom and synthetic antioxidants on hepatic tissue of aflatoxicosed rats

“…Self-recovery group and treated groups by either BPF, BHT and OPZ showed recovery of CBC by increases of all CBC except neutrophils. This improvement in CBC could be returned to promotion of the activity of proinflammatory cascade reactions (Takahashi and Hiraga 1984;Cottrell et al 1994;Petricevich and Pena 2002;Salman et al 2017).…”

Butylated Hydroxytoluene Toxicity

“…The main mechanism is assumed to be inhibition of 593 vitamin K epoxide reductase resulting in decreased synthesis of the clotting factors II, VII, IX and X (Takahashi 1987). An effect on platelet function (Takahashi & Hiraga, 1984) and on vitamin K absorption (Suzuki et al, 1983) have also been described.…”

“…While inhibition of vitamin K epoxide reductase is assumed to be the main mechanism of bleeding (Takahashi 1987) a disturbance of platelet function has also been described (Takahashi and Hiraga, 1984) . Notably, inhibition of platelet aggregation by BHT is not restricted to the agonist-induced event but is also directed towards phorbolester-induced activation of protein kinase C (PKC) (Alexandre et al, 1986) .…”

Final Report on the Safety Assessment of BHT

“…Plasma triglycerides, diglycerides, and lipid hydroperoxides were signi cantly decreased. A signi cant decrease in plasma zinc concentration was also observed in BHT-treated animals (Takahashi and Hiraga 1984).…”

Comparative ameliorative actions of extracted bradykinin potentiating fraction from cobra snake venom and synthetic antioxidants on hepatic tissue of aflatoxicosed rats

“…Self-recovery group and treated groups by either BPF, BHT and OPZ showed recovery of CBC by increases of all CBC except neutrophils. This improvement in CBC could be returned to promotion of the activity of proinflammatory cascade reactions (Takahashi and Hiraga 1984;Cottrell et al 1994;Petricevich and Pena 2002;Salman et al 2017).…”

Butylated Hydroxytoluene Toxicity

“…The main mechanism is assumed to be inhibition of 593 vitamin K epoxide reductase resulting in decreased synthesis of the clotting factors II, VII, IX and X (Takahashi 1987). An effect on platelet function (Takahashi & Hiraga, 1984) and on vitamin K absorption (Suzuki et al, 1983) have also been described.…”

“…While inhibition of vitamin K epoxide reductase is assumed to be the main mechanism of bleeding (Takahashi 1987) a disturbance of platelet function has also been described (Takahashi and Hiraga, 1984) . Notably, inhibition of platelet aggregation by BHT is not restricted to the agonist-induced event but is also directed towards phorbolester-induced activation of protein kinase C (PKC) (Alexandre et al, 1986) .…”

Final Report on the Safety Assessment of BHT

“…Plasma triglycerides, diglycerides, and lipid hydroperoxides were signi cantly decreased. A signi cant decrease in plasma zinc concentration was also observed in BHT-treated animals (Takahashi and Hiraga 1984).…”

Comparative ameliorative actions of extracted bradykinin potentiating fraction from cobra snake venom and synthetic antioxidants on hepatic tissue of aflatoxicosed rats

“…Self-recovery group and treated groups by either BPF, BHT and OPZ showed recovery of CBC by increases of all CBC except neutrophils. This improvement in CBC could be returned to promotion of the activity of proinflammatory cascade reactions (Takahashi and Hiraga 1984;Cottrell et al 1994;Petricevich and Pena 2002;Salman et al 2017).…”

Butylated Hydroxytoluene Toxicity

“…The main mechanism is assumed to be inhibition of 593 vitamin K epoxide reductase resulting in decreased synthesis of the clotting factors II, VII, IX and X (Takahashi 1987). An effect on platelet function (Takahashi & Hiraga, 1984) and on vitamin K absorption (Suzuki et al, 1983) have also been described.…”

“…While inhibition of vitamin K epoxide reductase is assumed to be the main mechanism of bleeding (Takahashi 1987) a disturbance of platelet function has also been described (Takahashi and Hiraga, 1984) . Notably, inhibition of platelet aggregation by BHT is not restricted to the agonist-induced event but is also directed towards phorbolester-induced activation of protein kinase C (PKC) (Alexandre et al, 1986) .…”