Effects of diabetes mellitus and aluminum toxicity on myocardial calcium transport

Dyslipidemia and Disruption of L-Carnitine in Aluminum Exposed Workers

“…Aluminum was reported to decrease the activity of (Ca+Mg)-ATPase, key enzyme involved in myocardial calcium transport. However, aluminum alone had no such effect, but its toxicity might potentiate the adverse effects of other stressful conditions or diseases on calcium regulatory myocardial protein calmodulin activity that may contribute to reduced sarcoplasmic reticulum calcium uptake (Levine et al, 1990). Many cases of arrhythmias, similar to our findings, have been recently reported among aluminum workers, thus suggesting the presence of toxic effects exerted by the metal on heart and blood vessels (Yildiz et al, 2012).…”

Dyslipidemia and Disruption of L-Carnitine in Aluminum Exposed Workers

“…Aluminum was reported to decrease the activity of (Ca+Mg)-ATPase, key enzyme involved in myocardial calcium transport. However, aluminum alone had no such effect, but its toxicity might potentiate the adverse effects of other stressful conditions or diseases on calcium regulatory myocardial protein calmodulin activity that may contribute to reduced sarcoplasmic reticulum calcium uptake (Levine et al, 1990). Many cases of arrhythmias, similar to our findings, have been recently reported among aluminum workers, thus suggesting the presence of toxic effects exerted by the metal on heart and blood vessels (Yildiz et al, 2012).…”

Aluminium alters excitability by inhibiting calcium, sodium and potassium currents in bovine chromaffin cells

“…Al 3+ seem to be able of altering long-term potentiation (LTP), affecting synaptic plasticity and, thus, memory (Li et al, 2020;Wang et al, 2010). In fact, Al 3+ interferes with phosphorylating processes affecting cAMP (Johnson et al, 1987), alters Ca 2+ /calmodulin-dependent enzymes (Levine et al, 1990), interferes with G-proteins (Haug et al, 1994;Shafer et al, 1993); all of them, targets involved in LTP process (Harris et al, 1984;Frey and Kandel, 1993;Malenka et al, 1989, Matthies andReymann, 1993). Moreover, Al 3+ alter calcium influx (Koenig and Jope, 1987), modifies the calcium binding to calmodulin (Siegel and Haug, 1982), and displaces calcium from phospholipid binding sites (Farnell et al,1985).…”

Pilot Study of Trace Elements in the Infusion of Medicinal Plants Used for Diabetes Treatment

“…Another study [ 40 ] suggested that exposure to arsenic causes oxidative stress, which, in turn, causes β -cell dysfunction and glucose homeostasis, and then induces diabetes, although this remains a hypothesis. It was found that aluminum toxicity causes adverse diabetic effects, in a study that investigated the effects of diabetes mellitus and aluminum toxicity [ 41 ]. A previous study [ 42 ] investigated the effect of aluminum exposure on rats' testicular tissue.…”

Dyslipidemia and Disruption of L-Carnitine in Aluminum Exposed Workers

“…Aluminum was reported to decrease the activity of (Ca+Mg)-ATPase, key enzyme involved in myocardial calcium transport. However, aluminum alone had no such effect, but its toxicity might potentiate the adverse effects of other stressful conditions or diseases on calcium regulatory myocardial protein calmodulin activity that may contribute to reduced sarcoplasmic reticulum calcium uptake (Levine et al, 1990). Many cases of arrhythmias, similar to our findings, have been recently reported among aluminum workers, thus suggesting the presence of toxic effects exerted by the metal on heart and blood vessels (Yildiz et al, 2012).…”

Aluminium alters excitability by inhibiting calcium, sodium and potassium currents in bovine chromaffin cells

“…Al 3+ seem to be able of altering long-term potentiation (LTP), affecting synaptic plasticity and, thus, memory (Li et al, 2020;Wang et al, 2010). In fact, Al 3+ interferes with phosphorylating processes affecting cAMP (Johnson et al, 1987), alters Ca 2+ /calmodulin-dependent enzymes (Levine et al, 1990), interferes with G-proteins (Haug et al, 1994;Shafer et al, 1993); all of them, targets involved in LTP process (Harris et al, 1984;Frey and Kandel, 1993;Malenka et al, 1989, Matthies andReymann, 1993). Moreover, Al 3+ alter calcium influx (Koenig and Jope, 1987), modifies the calcium binding to calmodulin (Siegel and Haug, 1982), and displaces calcium from phospholipid binding sites (Farnell et al,1985).…”

Pilot Study of Trace Elements in the Infusion of Medicinal Plants Used for Diabetes Treatment

“…Another study [ 40 ] suggested that exposure to arsenic causes oxidative stress, which, in turn, causes β -cell dysfunction and glucose homeostasis, and then induces diabetes, although this remains a hypothesis. It was found that aluminum toxicity causes adverse diabetic effects, in a study that investigated the effects of diabetes mellitus and aluminum toxicity [ 41 ]. A previous study [ 42 ] investigated the effect of aluminum exposure on rats' testicular tissue.…”

Dyslipidemia and Disruption of L-Carnitine in Aluminum Exposed Workers

“…Aluminum was reported to decrease the activity of (Ca+Mg)-ATPase, key enzyme involved in myocardial calcium transport. However, aluminum alone had no such effect, but its toxicity might potentiate the adverse effects of other stressful conditions or diseases on calcium regulatory myocardial protein calmodulin activity that may contribute to reduced sarcoplasmic reticulum calcium uptake (Levine et al, 1990). Many cases of arrhythmias, similar to our findings, have been recently reported among aluminum workers, thus suggesting the presence of toxic effects exerted by the metal on heart and blood vessels (Yildiz et al, 2012).…”

Aluminium alters excitability by inhibiting calcium, sodium and potassium currents in bovine chromaffin cells

“…Al 3+ seem to be able of altering long-term potentiation (LTP), affecting synaptic plasticity and, thus, memory (Li et al, 2020;Wang et al, 2010). In fact, Al 3+ interferes with phosphorylating processes affecting cAMP (Johnson et al, 1987), alters Ca 2+ /calmodulin-dependent enzymes (Levine et al, 1990), interferes with G-proteins (Haug et al, 1994;Shafer et al, 1993); all of them, targets involved in LTP process (Harris et al, 1984;Frey and Kandel, 1993;Malenka et al, 1989, Matthies andReymann, 1993). Moreover, Al 3+ alter calcium influx (Koenig and Jope, 1987), modifies the calcium binding to calmodulin (Siegel and Haug, 1982), and displaces calcium from phospholipid binding sites (Farnell et al,1985).…”

Pilot Study of Trace Elements in the Infusion of Medicinal Plants Used for Diabetes Treatment

“…Another study [ 40 ] suggested that exposure to arsenic causes oxidative stress, which, in turn, causes β -cell dysfunction and glucose homeostasis, and then induces diabetes, although this remains a hypothesis. It was found that aluminum toxicity causes adverse diabetic effects, in a study that investigated the effects of diabetes mellitus and aluminum toxicity [ 41 ]. A previous study [ 42 ] investigated the effect of aluminum exposure on rats' testicular tissue.…”