Effects of demographic factors on cortical thickness in Alzheimer's disease

Seo, Sang Won; Im, Kiho; Lee, Jongmin; Kim, Sung Tae; Ahn, Hyun Young; Go, Seok Min; Kim, Sook Hui; Na, Duk L.

doi:10.1016/j.neurobiolaging.2009.02.004

Cited by 73 publications

(62 citation statements)

References 49 publications

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“…13,14 In accordance with this finding, the results of cortical thickness analysis demonstrated more severe cortical atrophy in AD dementia subjects with HE. 15 The cognitive reserve thanks to high education would be protective against the beginning of overt clinical symptoms of cognitive decline and impairment of daily activities. 13,14 It may delay the development of dementia although the brain pathology has progressed substantially.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Characteristics according to the Educational Level in the Elderly Patients with Mild Alzheimer's Disease Dementia

Shin

Lee

et al. 2015

Dement Neurocognitive Disord

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Background and Purpose Cognitive reserve is important for the individual susceptibility to dementia. Among the various determinants of cognitive reserve, the number of years of formal education would be of prime importance. We performed this study to explore its contribution to the clinical characteristics of dementia. Methods We included consecutive mild Alzheimer's disease (AD) dementia patients (clinical dementia rating, CDR=0.5 or 1) who visited our memory clinic and were older than 70 years at the evaluation from October 2013 to September 2015. According to the number of years of education, the corresponding subjects was grouped into two extreme educational groups, low education (illiterate or partially illiterate, LE, n=43) vs. high education (more than 9 years of education, HE, n=34). Among these patients, we compared various demographic, neuropsychological and neuroimaging characteristics. Results The groups were comparable in terms of age, frequency of hypertension and diabetes, and CDR and its sum of box. However, female gender was more frequent in the LE group (p=0.000). Also this group showed a more depressive mood on the geriatric depression scale (p=0.007). The raw scores on Korean Version of Mini-Mental State Examination and well-validated neuropsychological tests were lower in the LE group. However, the cognitive performance was found to be more preserved in the LE group than in the HE group when assessed using the z-score in certain specified tests on univariate and multivariate analyses (p<0.05). The Schelten's grade of medial temporal atrophy was similar between the two educational groups. Also, the degree of combined ischemic burden did not differ between the two groups. Conclusions We identified that the prevalence of depressive mood and the extent of decline from the corresponding norm in a particular neuropsychological performance differ according to the educational level of mild AD patients.

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Section: Discussionmentioning

confidence: 99%

The Clinical Characteristics according to the Educational Level in the Elderly Patients with Mild Alzheimer's Disease Dementia

Shin

Lee

et al. 2015

Dement Neurocognitive Disord

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“…From a structural point of view, although negative relationships Bastin et al, 2012;Coffey et al, 1999;Querbes et al, 2009) or null findings (Christensen et al, 2009;Seo et al, 2011) have also been reported, several neuroimaging studies in cognitively healthy elders highlighted positive relationships between brain 5 measures and education. Thus, greater gray matter volume and cortical thickness in temporoparietal areas (Foubert-Samier et al, 2012, Liu et al, 2012, larger cortical thickness in orbitofrontal lobe (Liu et al, 2012) as well as greater white matter volume in regions connecting these latter areas (Foubert-Samier et al, 2012) and decreased mean diffusivity in the bilateral hippocampus (Piras et al, 2011) have been found in elderly with greater education.…”

Section: Introductionmentioning

confidence: 99%

Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders

et al. 2013

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More educated elders are less susceptible to age-related or pathological cognitive changes. We aimed at providing a comprehensive contribution to the neural mechanism underlying this effect thanks to a multimodal approach. Thirtysix healthy elders were selected based on neuropsychological assessments and cerebral amyloid imaging, i.e. as presenting normal cognition and a negative florbetapir-PET scan. All subjects underwent structural MRI, FDG-PET and resting-state functional MRI scans. We assessed the relationships between years of education and i) gray matter volume, ii) gray matter metabolism and iii) functional connectivity in the brain areas showing associations with both volume and metabolism. Higher years of education were related to greater volume in the superior temporal gyrus, insula and anterior cingulate cortex and to greater metabolism in the anterior cingulate cortex. The latter thus showed both volume and metabolism increases with education. Seed connectivity analyses based on this region showed that education was positively related to the functional connectivity between the anterior cingulate cortex and the hippocampus as well as the inferior frontal lobe, posterior cingulate cortex and angular gyrus. Increased connectivity was in turn related with improved cognitive performances. Reinforcement of the connectivity of the anterior cingulate cortex with distant cortical areas of the frontal, temporal and parietal lobes appears as one of the mechanisms underlying education-related reserve in healthy elders.

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“…The early development of dementia in Alzheimer's disease beginning under the age of 65 is related to gene mutations in subsequent generations (sibling, parent, grandparent with Alzheimer's disease) [11]. The research into Alzheimer's disease conducted in Korea shows that the mean age of study participants was 73.5 (±7.3) and the disease was diagnosed more frequently in women 69.4%, the values being lower than those in the current study (79.82 ± 8.05 years; 78.4% women) [12]. Even a lower mean age of patients diagnosed with Alzheimer's disease was reported from Japan (71.1 ± 9.7), with a decreased percentage of women (52.5%) [13].…”

Section: Discussionmentioning

confidence: 63%

The Prevalence of Alzheimer’s Disease and Dementia in Alzheimer’s Disease in Patients of Long-Term Nursing Home Care in the Podlaskie Province in Poland

Mojsa¹

2015

AAD

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The prevalence of Alzheimer's disease and dementia in Alzheimer's disease according to the International Statistical Classification of Diseases and Related Health Problems ICD-10 in patients of long-term nursing home care in the Podlaskie province is not yet known. The aim of the study was the socio-demographic assessment of the long-term nursing home care patients with diagnosed Alzheimer's disease and socio-demographic assessment of the long-term nursing home care patients with dementia in Alzheimer's disease. Data concerning all 7637 patients who received longterm nursing home care benefits in the years from 2008 to 2013 in the Podlaskie province were investigated. Alzheimer's disease was diagnosed in 2.972% of patients at the average age of 79.82 years (±8.05). The disease was diagnosed more frequently (78.4%) and earlier in women (from 44 years of age). Dementia in Alzheimer's disease was diagnosed in 210 patients (2.749%). The mean age of patients with Alzheimer's dementia was 81.72 years (±7.73). Stupor in patients under 65 years more frequently affected women. Research confirms the impact of Alzheimer's disease and dementia in Alzheimer's disease on daily activity performance. Studies suggest that the high rate of Alzheimer's disease and dementia in Alzheimer's disease is due to ethnic and national differences associated with learning at home and in schools in the Podlaskie province.

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Effects of demographic factors on cortical thickness in Alzheimer's disease

Cited by 73 publications

References 49 publications

The Clinical Characteristics according to the Educational Level in the Elderly Patients with Mild Alzheimer's Disease Dementia

The Clinical Characteristics according to the Educational Level in the Elderly Patients with Mild Alzheimer's Disease Dementia

Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders

The Prevalence of Alzheimer’s Disease and Dementia in Alzheimer’s Disease in Patients of Long-Term Nursing Home Care in the Podlaskie Province in Poland

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