Effects of delta-sleep-inducing peptide in cerebral ischemia in rats

Шандра, А. А.; Godlevskii, L. S.; Brusentsov, A. I.; Vastyanov, R. S.; Karlyuga, V. A.; Dzygal, O. F.; Nikel, B.

doi:10.1007/bf02464804

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…A neuroprotective effect has been demonstrated in rats subjected to bilateral carotid ligation [30]. A reduced mortality was observed together with a reduction in postischaemia function.…”

Section: Non‐sleep Effectsmentioning

confidence: 99%

Delta sleep-inducing peptide

Pollard

Pomfrett

2001

Eur J Anaesthesiol

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“…A neuroprotective effect has been demonstrated in rats subjected to bilateral carotid ligation [30]. A reduced mortality was observed together with a reduction in postischaemia function.…”

Section: Non‐sleep Effectsmentioning

confidence: 99%

Delta sleep-inducing peptide

Pollard

Pomfrett

2001

Eur J Anaesthesiol

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“…In Wistar rats, DSIP has been reported to reduce mortality, decrease the electrical activity of the brain, and increase cerebral blood flow in ischemic brain under conditions of global cerebral ischemia aggravated by pre-stress [4]. An even earlier study demonstrated a high potential of DSIP to reduce mortality when administered preventively 1 h before global cerebral ischemia in Wistar rats [5]. Given that KND is a more active analog of DSIP, it is of high interest to study its effect on the outcome of ischemia-reperfusion injuries that develop after transient myocardial infarction and transient focal cerebral stroke.…”

Section: Introductionmentioning

confidence: 99%

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

et al. 2021

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A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in C57Bl/6 mice. A significant decrease in the myocardial infarction area was registered in KND-treated animals relative to saline-treated control animals (19.1 ± 7.3% versus 42.1 ± 9.2%). The brain infarction volume was significantly lower in animals intranasally treated with KND compared to the control saline-treated animals (7.4 ± 3.5% versus 12.2 ± 5.6%). Injection of KND in the first minute of reperfusion in the models of myocardial infarction and cerebral stroke reduced infarction of these organs, indicating a pronounced cardioprotective and neuroprotective effect of KND and potentiality for the treatment of ischemia-reperfusion injuries after transient ischemic attacks on the heart and brain, when administered during the reperfusion period. A preliminary pilot study using the model of myocardial infarction with the administration of DSIP during occlusion, and the model of cerebral stroke with the administration of KND during occlusion, resulted in 100% mortality in animals. Thus, in the case of ischemia-reperfusion injuries of the myocardium and the brain, use of these peptides is only possible during reperfusion.

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“…DSIP also has neuroprotective properties. Accordingly, the treatment of Wistar rats with DSIP several hours prior to global brain ischemia improved locomotor functions and reduced lethality [ 23 ]. DSIP reduced neuronal activity and improved blood supply of the brain of stressed animals subjected to brain ischemia [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

et al. 2021

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Background and Objectives: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated. Materials and Methods: The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated. DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg. The battery of behavioral tests was performed on 1, 3, 7, 14, and 21 days after MCAO. Motor coordination and balance and bilateral asymmetry were tested. At the end of the study, animals were euthanized, and their brains were perfused, serial cryoslices were made, and infarction volume in them was calculated. Results: Although brain infarction in DSIP-treated animals was smaller than in vehicle-treated animals, the difference was not significant. However, motor performance in the rotarod test significantly recovered in DSIP-treated animals. Conclusions: Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.

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Effects of delta-sleep-inducing peptide in cerebral ischemia in rats

Cited by 9 publications

References 4 publications

Delta sleep-inducing peptide

Delta sleep-inducing peptide

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

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