Effects of Cyperus articulatus compared to effects of anticonvulsant compounds on the cortical wedge

Bum, Elisabeth Ngo; Rakotonirina, A.; Rakotonirina, S.V.; Herrling, Paul L.

doi:10.1016/s0378-8741(03)00103-x

Cited by 17 publications

(11 citation statements)

References 17 publications

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“…A voucher specimen (Rakotonirina 002, reference 1256/HNC) was authentified and deposited in the National Herbarium of Cameroon. Extracts of Cyperus articulatus used were obtained according to a method described previously by Ngo Bum et al, 2003. Rhizomes were ground in a mill to a grain size of <1 mm. From this powder, the extract was made as follows: the plant material (112 g) was first extracted three times after 10 min of maceration at each time with ethyl acetate (3 × 1.5 l), the extract was filtered.…”

Section: Plant Extractionmentioning

confidence: 99%

Ions and amino acid analysis of Cyperus articulatus L. (Cyperaceae) extracts and the effects of the latter on oocytes expressing some receptors

Bum

Lingenhoehl

Rakotonirina

et al. 2004

Journal of Ethnopharmacology

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Section: Plant Extractionmentioning

confidence: 99%

Ions and amino acid analysis of Cyperus articulatus L. (Cyperaceae) extracts and the effects of the latter on oocytes expressing some receptors

Bum

Lingenhoehl

Rakotonirina

et al. 2004

Journal of Ethnopharmacology

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“…However, such drugs show serious side effects like ischemia, hepatotoxicity depression, cognitive disorders, and motor disability. 9 Additionally, 20–30% of those patients are resistant to treatments with synthetic drugs so, it is necessary to discover new treatments by using the natural medicine to reduce the complications or side effects of antiepileptic drugs.…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant effect of ethanolic extract of Cyperus articulatus L. leaves on pentylenetetrazol induced seizure in mice

Herrera-Calderon

Santiváñez-Acosta

Enciso-Roca

et al. 2018

Journal of Traditional and Complementary Medicine

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Cyperus articulatus (CA) rhizomes have demonstrated different properties on nervous system. However, the leaves still have not studied to treat epilepsy. The aim of this study was to determine the effect of CA ethanolic extract on pentylenetetrazol (PTZ) induced seizures in mice as well as measuring its antioxidant activity in vivo and in vitro. Mice were divided into five groups: (1) control (PTZ 80 mg/kg; i.p.), (2) PTZ-Diazepam (1 mg/kg; i.p.), (3–5) PTZ-CA 50, PTZ-CA 150 and PTZ-CA 300 (50, 150 and 300 mg/kg of CA extract, 30 min prior to each PTZ injection). The PTZ-CA 150 group showed lower seizure scores (P < 0.01), latency (P < 0.01), frequency (P < 0.01) and duration (P < 0.01) than control group. The antioxidant activity of CA extract scavenged DPPH radical showed IC 50 = 16.9 ± 0.1 μg/mL and TEAC = 2.28 ± 0.08, mmol trolox/g of extract, the content of gamma amino butyric acid (GABA) and malondialdehyde (MDA) were significantly high (P < 0.01) at dose of 150 mg/kg (82 ± 1.2 ng/g tissue; 1.0 ± 2.2 mol/g tissue, respectively). The present research demonstrated that CA extract possesses a potential effect to prevent PTZ induced seizures, antioxidant activity in addition to increase GABA levels.

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“…C. articulatus (Cyperaceae), commonly known as Piri piri, is a useful Indian medicinal plant that has been credited with therapeutic properties for the treatment of various diseases such as headaches, migraines and epilepsy (Bum et al 2003).…”

Section: Medicinal and Therapeutic Propertiesmentioning

confidence: 99%

Medical, Therapeutic and Pharmaceutical use of Cyperus articulatus L.

et al. 2020

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Cyperus articulatus L., pertencente à família Cyperaceae, é uma espécie vegetal que tem, em suas extremidades, flores, quase insignificantes. Os talos da espécie produzem tubérculos que, quando cortados, exalam um cheiro fresco, amadeirado e picante; são tradicionalmente usados em banhos e na manufatura de colônias artesanais na região norte do Brasil. Além do uso em cosméticos e perfumaria, a planta também possui propriedades medicinais e farmacológicas. Entre as propriedades farmacológicas estão os efeitos antimalárico, sedativo, hepatoprotetor, contraceptivo, no sistema nervoso central (SNC), insecticida, antimicrobiano, anticancerígeno, antioxidante, anticonvulsante, antioncocercose. Os metabólitos encontrados relacionados às atividades mencionadas foram ciperotundona, alfa-ciperona, mustacona para atividade antimalárica no extrato de clorofórmio dos rizomas da priprioca. Na decocção dos rizomas de C. articulatus foram encontrados flavonóides, saponinas, açúcares, triterpenos e poliuronídeos para propriedades sedativas. Não foram encontrados na literatura metabólitos envolvidos na função hepatoprotetora, no efeito contraceptivo e no efeito do sistema nervoso central. Os metabólitos aromáticos de mono- e sesquiterpenos foram relacionados a propriedades inseticidas no extrato metanólico de rizoma. Nos extratos etanólicos e clorofórmicos dos rizomas, os metabólitos α e β-pineno estavam relacionados à atividade antimicrobiana. Os compostos sesquiterpenos e monoterpenos encontrados no óleo essencial de C. articulatus foram relacionados às propriedades anticâncer. Os compostos fenólicos do óleo essencial de C. articulatus foram relacionados às propriedades antioxidantes. Os compostos alcalóides achados no extrato do rizoma de C. articulatus apresentaram atividade anticonvulsivante. Os metabólitos mustakona e o ácido linoléico encontrados no extrato de rizomas de C. articulatus estavam diretamente relacionados às propriedades antioncocercais. O presente trabalho revisou as propriedades médicas, terapêuticas e farmacológicas de Cyperus articulatus.

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Effects of Cyperus articulatus compared to effects of anticonvulsant compounds on the cortical wedge

Cited by 17 publications

References 17 publications

Ions and amino acid analysis of Cyperus articulatus L. (Cyperaceae) extracts and the effects of the latter on oocytes expressing some receptors

Ions and amino acid analysis of Cyperus articulatus L. (Cyperaceae) extracts and the effects of the latter on oocytes expressing some receptors

Anticonvulsant effect of ethanolic extract of Cyperus articulatus L. leaves on pentylenetetrazol induced seizure in mice

Medical, Therapeutic and Pharmaceutical use of Cyperus articulatus L.

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