Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress

Liu, Dexiang; Wang, Zhen; Ze, Gao; Xie, Kai; Zhang, Qingrui; Jiang, Hong; Pang, Qi

doi:10.1016/j.bbr.2014.05.068

Cited by 135 publications

(91 citation statements)

References 45 publications

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“…15,41,42,[56][57][58] ERK1/2, a member of mitogen-activated protein kinases family, is widely distributed in the mammalian nervous system. It has been reported that ERK1/2 is critical for the functions of normal brain, cell survival, and major depression.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Zhu

Wang

et al. 2016

IJN

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Major depression is a complex neuropsychiatric disorder with few treatment approaches. The use of nontargeted antidepressants induced many side effects with their low efficacy. A more precise targeting strategy is to develop nanotechnology-based drug delivery systems; hence, we employed solid lipid nanoparticles (SLNs) to encapsulate HU-211 and curcumin (Cur). The antidepressant effects of the dual-drug nanoparticles (Cur/SLNs-HU-211) for major depression treatment were investigated in corticosterone-induced cellular and animal models of major depression. Cur/SLNs-HU-211 can effectively protect PC12 cells from corticosterone-induced apoptosis and can release more dopamine, which may be associated with the higher uptake of Cur/SLNs-HU-211 shown by cellular uptake behavior analysis. Additionally, Cur/SLNs-HU-211 significantly reduced the immobility time in forced swim test, enhanced fall latency in rotarod test, and improved the level of dopamine in mice blood. Cur/SLNs-HU-211 can deliver more Cur to the brain and thus produce a significant increase in neurotransmitters level in brain tissue, especially in the hippocampus and striatum. The results of Western blot and immunofluorescence revealed that Cur/SLNs-HU-211 can significantly enhance the expression of CB1, p-MEK1, and p-ERK1/2. Our study suggests that Cur/SLNs-HU-211 may have great potential for major depression treatment.

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Section: Discussionmentioning

confidence: 99%

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Zhu

Wang

et al. 2016

IJN

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“…Several studies have shown the involvement of this signaling pathway in MDD. Animal models of depression induced by chronic stress or corticosterone treatment are associated with decreased levels of ERK1/2 in prefrontal cortex and hippocampus of mice [63,64]. Also, the inhibition of MEK/ERK cascade induces a depressive-like behavior and abolishes the effect of some antidepressants including desipramine, sertraline, and ketamine [65,66].…”

Section: Discussionmentioning

confidence: 99%

Signaling pathways underlying the antidepressant-like effect of inosine in mice

Gonçalves

Neis

Rieger

et al. 2016

Purinergic Signalling

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Inosine is a purine nucleoside formed by the breakdown of adenosine that elicits an antidepressant-like effect in mice through activation of adenosine A 1 and A 2A receptors. However, the signaling pathways underlying this effect are largely unknown. To address this issue, the present study investigated the influence of extracellular-regulated protein kinase (ERK)1/2, Ca 2+ /calmoduline-dependent protein kinase (CaMKII), protein kinase A (PKA), phosphoinositide 3-kinase (PI3K)/Akt, and glycogen synthase kinase 3beta (GSK-3β) modulation in the antiimmobility effect of inosine in the tail suspension test (TST) in mice. In addition, we attempted to verify if inosine treatment was capable of altering the immunocontent and phosphorylation of the transcription factor cyclic adenosine monophosphatate (cAMP) responsebinding element protein (CREB) in mouse prefrontal cortex and hippocampus. Intracerebroventricular administration of U0126 (5 μg/mouse, MEK1/2 inhibitor), KN-62 (1 μg/ mouse, CaMKII inhibitor), H-89 (1 μg/mouse, PKA inhibitor), and wortmannin (0.1 μg/mouse, PI3K inhibitor) prevented the antiimmobility effect of inosine (10 mg/kg, intraperitoneal (i.p.)) in the TST. Also, administration of a subeffective dose of inosine (0.1 mg/kg, i.p.) in combination with a sub-effective dose of AR-A014418 (0.001 μg/mouse, GSK-3β inhibitor) induced a synergic antidepressant-like effect. None of the treatments altered locomotor activity of mice. Moreover, 24 h after a single administration of inosine (10 mg/kg, i.p.), CREB phosphorylation was increased in the hippocampus. Our findings provided new evidence that the antidepressant-like effect of inosine in the TST involves the activation of PKA, PI3K/Akt, ERK1/2, and CaMKII and the inhibition of GSK-3β. These results contribute to the comprehension of the mechanisms underlying the purinergic system modulation and indicate the intracellular signaling pathways involved in the antidepressant-like effect of inosine in a preclinical test of depression.

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“…Chronic mild stress does not only lead to depression-like behaviors suggesting alteration in affective processes but also impaired cognitive performance as assessed in several learning and memory paradigms such as Morris water maze and object recognition test [8][9][10]. Among the multiple neurochemical changes that occur in response to stressors, excessive inflammation processes is thought to play a major role in resultant cognitive impairments [11].…”

Section: Introductionmentioning

confidence: 98%

TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

Şahin

Karson

Balcı

et al. 2015

Behavioural Brain Research

100

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Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress

Cited by 135 publications

References 45 publications

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Signaling pathways underlying the antidepressant-like effect of inosine in mice

TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

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