Effects of Curcumin and Its Analogues on Infectious Diseases

Ranjbar, Reza; Bagheri, Hossein; Ghasemi, Faezeh; Guest, Paul C.; Sahebkar, Amirhossein

doi:10.1007/978-3-030-56153-6_5

Cited by 6 publications

(2 citation statements)

References 162 publications

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“…Cur and its analogs have been characterized as multifunctional drugs with antitumoral, antiinfectious, and anti-inflammatory properties. [16,17] In addition, Cur possesses antioxidant, antiapoptotic, and cell-protective effects. These effects are mediated by regulation of various intricate cellular networks as determined by experimental toxicity tests.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of autophagic flux by the curcumin analog EF‐24 and its antiproliferative effect on MCF‐7 cancer cells

Wang

Liu

et al. 2023

J Biochem & Molecular Tox

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5‐Bis[(2‐fluorophenyl)methylene]‐4‐piperidinone (EF‐24) is a curcumin analog, which was identified for its physiochemical stability and diverse pharmacological functions. In the present study, EF‐24 was added to the breast cancer cell line MCF‐7 and its cellular effects were characterized. The results indicated that EF‐24 possessed antiproliferative and antimigratory activities on MCF‐7 cells as determined by MTT assay, wound healing, and transwell assay, respectively. In addition, the autophagosomal vesicles could be detected by acridine orange staining and electron microscope analysis in EF‐24‐treated cells. Conversion of LC3‐I to LC3‐II was also investigated following EF‐24 treatment of the cells. However, the expression analysis of p62 and LC3 revealed that EF‐24 could inhibit autophagic flux in MCF‐7 cells. Confocal microscopy suggested that EF‐24 could inhibit the degradation of autophagic vesicles by blocking the fusion of autophagosomes with lysosomes. EF‐24 could also induce apoptosis of MCF‐7 cells as determined by Hoechst 33342 staining, flow cytometry analysis, and western blot analysis. Moreover, treatment of the cells with the autophagy inhibitor 3‐MA enhanced the PARP1 cleavage of EF‐24‐treated MCF‐7 cells, which indicated the crosstalk between autophagy and apoptosis in breast cancer cells. Additional investigation of EF‐24 should be performed in future studies to assess its antiproliferation and antimigratory effects on MCF‐7 cells. However, the current results provide a solid foundation for the potential in vivo anticancer activity of this compound.

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Section: Discussionmentioning

confidence: 99%

Inhibition of autophagic flux by the curcumin analog EF‐24 and its antiproliferative effect on MCF‐7 cancer cells

Wang

Liu

et al. 2023

J Biochem & Molecular Tox

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“…Researchers have reported that the methoxy and hydroxy derivatives of curcumin are specifically related to its antibacterial efficacy [12,13]. Although many some reviews on the use of curcumin and its analogues that are associated with its antimicrobial and anti-parasitic properties in specific applications (i.e., wound healing, periodontal diseases, tuberculosis, Helicobacter pylori infection) have been published in recent decades [14][15][16], there is a need for a comprehensive literature review that includes both the studies that have been performed on the antimicrobial activity of curcumin and those reporting the technological approaches in order to have a vision of what has been achieved so far and to direct future studies.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

et al. 2022

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Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that exhibit antioxidant properties. It has a broad spectrum of antibacterial actions against a wide range of bacteria, even those resistant to antibiotics. Curcumin has been shown to be effective against the microorganisms that are responsible for surgical infections and implant-related bone infections, primarily Staphylococcus aureus and Escherichia coli. The efficacy of curcumin against Helicobacter pylori and Mycobacterium tuberculosis, alone or in combination with other classic antibiotics, is one of its most promising antibacterial effects. Curcumin is known to have antifungal action against numerous fungi that are responsible for a variety of infections, including dermatophytosis. Candidemia and candidiasis caused by Candida species have also been reported to be treated using curcumin. Life-threatening diseases and infections caused by viruses can be counteracted by curcumin, recognizing its antiviral potential. In combination therapy with other phytochemicals, curcumin shows synergistic effects, and this approach appears to be suitable for the eradication of antibiotic-resistant microbes and promising for achieving co-loaded antimicrobial pro-regenerative coatings for orthopedic implant biomaterials. Poor water solubility, low bioavailability, and rapid degradation are the main disadvantages of curcumin. The use of nanotechnologies for the delivery of curcumin could increase the prospects for its clinical application, mainly in orthopedics and other surgical scenarios. Curcumin-loaded nanoparticles revealed antimicrobial properties against S. aureus in periprosthetic joint infections.

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Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors

Roney,

Huq,

Rullah

et al. 2024

Cell Biochem Biophys

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Effects of Curcumin and Its Analogues on Infectious Diseases

Cited by 6 publications

References 162 publications

Inhibition of autophagic flux by the curcumin analog EF‐24 and its antiproliferative effect on MCF‐7 cancer cells

Inhibition of autophagic flux by the curcumin analog EF‐24 and its antiproliferative effect on MCF‐7 cancer cells

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors

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