Effects of cross-fostering and developmental exposure to mixtures of environmental contaminants on hepatic gene expression in prepubertal 21 days old and adult male Sprague-Dawley rats

Desaulniers, Daniel; Khan, Nadeem; Cummings-Lorbetskie, Cathy; Leingartner, Karen; Gh, Xiao; Williams, Andrew; Yauk, Carole L.

doi:10.1080/15287394.2018.1542360

Cited by 4 publications

(1 citation statement)

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“…The role played by HEPH in iron metabolism in lung is still poorly characterized, and so is its possible contribution to lung carcinogenesis and growth. We recently identified a single-nucleotide polymorphism within HEPH gene, leading to a missense variation of this multicopper ferroxidase, which confers protection against asbestos-dependent malignant pleural mesothelioma and lung carcinoma in exposed subjects ( 24 , 25 ). Moreover, in breast cancer HEPH expression has been shown to be down-regulated by the histone methyltransferase G9a, leading to changes in iron homeostasis that burst cancer growth ( 26 ).…”

Section: Introductionmentioning

confidence: 99%

The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value

et al. 2021

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Hephaestin (HEPH) belongs to a group of exocytoplasmic ferroxidases which contribute to cellular iron homeostasis by favouring its export. Down-regulation of HEPH expression, possibly by stimulating cell proliferation due to an increase in iron availability, has shown to correlate with poor survival in breast cancer. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tension present, however, HEPH distribution in lung cancer and its influence on prognosis have not been investigated yet. In this study we explored the prognostic value of HEPH and its expression pattern in the most prevalent histotypes of lung cancers, namely lung adenocarcinoma and lung squamous cell carcinoma. In silico analyses, based on UALCAN, Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan–Meier plotter bioinformatics, revealed a significant correlation between higher levels of HEPH expression and favorable prognosis, in both cancer histotypes. Moreover, TIMER web platform showed a statistically significant association between HEPH expression and cell elements belonging to the tumor microenvironment identified as endothelial cells and a subpopulation of cancer-associated fibroblasts, further confirmed by double immunohistochemical labeling with cell type specific markers. Taken together, these data shed a light on the complex mechanisms of local iron handling lung cancer can exploit to support tumorigenesis.

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Section: Introductionmentioning

confidence: 99%

The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value

et al. 2021

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Children's Health and Exposure to Chemicals in the Natural and Built Environment

Goldhaber,

Slover,

Mullikin

et al. 2024

Human and Ecological Risk Assessment

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The extract from the roots of Rose odorata sweet var. gigantean (Coll. et Hemsl.) Rehd. et Wils attenuates DSS-induced ulcerative colitis by regulating the Nrf2/NF-κB signaling pathways

Zhao

et al. 2020

RSC Adv.

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Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease. Many natural medicines or ethnic drugs have been proven to be effective and beneficial in the treatment of UC. Among these, the root of Rose odorata sweet var. gigantean (Coll. et Hemsl.) Rehd. et Wils. (ROS), a kind of Yi nationality medicine called "GU-GONG-GUO," has been shown to be useful as a therapeutic agent for sputum and diarrhea. However, the effects and mechanisms of ROS extract (ROE) on UC remain relatively unknown. The aim of this study was to explore the protective effects and the underlying mechanisms of ROE on UC. First, we established a dextran sulfate sodium (DSS)-induced experimental colitis mouse model and then evaluated the anti-inflammatory effects of ROE in vivo. Then, RAW264.7 cells were stimulated with lipopolysaccharide (LPS) in the presence or absence of ROE to explore its mechanisms in vitro. It was found that ROE attenuated DSS-induced colon length shortening, body weight loss, and colonic pathological damage. Furthermore, ROE inhibited the activity of nitric oxide synthase (NOS), myeloperoxidase (MPO), and malondialdehyde (MDA). Also, ROE decreased several LPS-induced inflammatory cytokines including TNF-a, IL-6, and IL-1b in RAW264.7. In addition, ROE inhibited the expression of p-NF-kB, p-IKKa/b, and Keap1 proteins and increased the expression of Nrf2 and HO-1 proteins. Our study suggested that ROE prevented DSS-induced colitis though the Nrf2/NF-kB pathway.Overall, it can be concluded that ROE may be a promising and effective agent for UC.rsc.li/rsc-advances 9450 | RSC Adv., 2020, 10, 9450-9461This journal is

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Effects of cross-fostering and developmental exposure to mixtures of environmental contaminants on hepatic gene expression in prepubertal 21 days old and adult male Sprague-Dawley rats

Abstract: 2019) Effects of cross-fostering and developmental exposure to mixtures of environmental contaminants on hepatic gene expression in prepubertal 21 days old and adult male Sprague-Dawley rats,

Cited by 4 publications

References 125 publications

The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value

The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value

Children's Health and Exposure to Chemicals in the Natural and Built Environment

The extract from the roots of Rose odorata sweet var. gigantean (Coll. et Hemsl.) Rehd. et Wils attenuates DSS-induced ulcerative colitis by regulating the Nrf2/NF-κB signaling pathways

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