Effects of cranberry juice consumption on vascular function in patients with coronary artery disease

Dohadwala, Mustali M; Holbrook, Monika; Hamburg, Naomi M.; Shenouda, Sherene M.; Chung, William; Titas, Megan; Kluge, Matthew A.; Wang, Na; Palmisano, Joseph; Milbury, Paul E.; Blumberg, Jeffrey B.; Vita, Joseph A.

doi:10.3945/ajcn.110.004242

Cited by 229 publications

(262 citation statements)

References 40 publications

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“…The significant increase in acute FMD following consumption of the polyphenol-rich drink is consistent with other studies conducted in non-athlete populations [16][17][18][19]. For instance, FMD was increased after consumption of 477 mg of polyphenols from non-alcoholized red wine in healthy subjects [18].…”

Section: Study 1-polyphenols and Fmdsupporting

confidence: 79%

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Labonté

Couillard

Motard-Belanger

et al. 2013

Sports

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Abstract:We examined how intake of polyphenols modifies brachial artery flow-mediated dilation (FMD) at rest, and cycling anaerobic performance, in elite athletes. In the first randomized cross-over study, FMD was measured over a three-hour period on two occasions in eight elite male and female athletes after acute consumption of either polyphenols from cranberries and grape seeds (600 mg) or a polyphenol-free placebo drink. Consumption of the polyphenol-rich drink led to a significant increase in FMD compared to placebo (p = 0.02), with a peak at 60 min. In a second study, 12 elite male and female athletes completed a threekilometer time trial (TT) on an ergocycle on two occasions in random order, either after consumption of 800 mg of polyphenols or a placebo. Acute intake of the polyphenol extract had no impact on the three-kilometer time trial completion. However, plasma lactate levels were significantly lower before and after the TT when subjects consumed the polyphenols vs. placebo (p < 0.05). Results suggest that polyphenols from cranberries and grape seeds acutely modifies FMD at rest in elite athletes but this does not translate into enhanced cycling anaerobic performance. OPEN ACCESSSports 2013, 1 56

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Section: Study 1-polyphenols and Fmdsupporting

confidence: 79%

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Labonté

Couillard

Motard-Belanger

et al. 2013

Sports

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show abstract

“…However, among patients with the correct RHI, the consumption of olive oil did not contribute to any improvement of this parameter . Another study showed that in patients with the coronary arterial disease the endothelial function improved in 2 h after drinking the cranberry juice (480 ml) but this effect was not found in long-term research (4 weeks) (Dohadwala et al 2011).…”

Section: Resultsmentioning

confidence: 99%

Effect of chokeberry juice consumption on antioxidant capacity, lipids profile and endothelial function in healthy people: a pilot study

Nowak¹,

Grąbczewska²,

Gośliński³

et al. 2016

Czech J. Food Sci.

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Nowak D., Grąbczewska Z., Gośliński M., Obońska K., Dąbrowska A., Kubica J. (2016): Effect of chokeberry juice consumption on antioxidant capacity, lipids profile and endothelial function in healthy people: a pilot study. Czech J. Food Sci., 34: 39-46.Many studies show that the consumption of juices rich in polyphenols may increase serum antioxidant capacity, improve blood lipid profile, and endothelial function. The relation between the consumption of chokeberry juice and changes in the antioxidant capacity, blood lipid profile, and endothelial function as important indicators in the assessment of cardiovascular risk were determined. The study was conducted on a group of 11 healthy volunteers, who consumed chokeberry juice for three weeks. The research included determination of serum antioxidant capacity, blood lipid profile analysis, and measurements of endothelial function. The 3-week consumption of chokeberry juice significantly increased serum antioxidant capacity, and the best results were observed just after one week of the experiment. However, there was no significant change in the blood lipid profile, except for the persons with a higher level of triglycerides, in whom the consumption of chokeberry juice reduced these compounds to normal values. The endothelial function was normal in all patients and did not significantly change during the study.

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“…However, we did not find that CEB consumption for 8 week improved fasting glycemic parameters in healthy overweight adults. Similarly, cranberry juice consumption for 4 week did not affect fasting glucose, insulin, or HOMA-IR in subjects with CAD [19]. Thus, the long-term benefit of cranberry polyphenols on fasting glycemic control may be more evident in people with impaired glucose control.…”

Section: Glucoregulationmentioning

confidence: 92%

“…To date, studies have explored the effect of cranberry juice on CVD risk factors in healthy subjects [10][11][12][13][14][15] as well as in patients with type 2 diabetes (T2DM) [16][17][18], coronary artery disease (CAD) [19], endothelial dysfunction [20], and metabolic syndrome [21]. However, only 2 of these trials have examined people with CVD risk factors other than hypercholesterolemia and T2DM, e.g.…”

Section: Introductionmentioning

confidence: 99%

Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial

et al. 2018

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Purpose We studied the health benefits of low calorie cranberry beverage consumption on glucoregulation, oxidative damage, inflammation, and lipid metabolism in overweight but otherwise healthy humans. Methods 78 overweight or obese men and women (30-70 years; BMI 27-35 kg/m 2 ) with abdominal adiposity (waist: hip > 0.8 for women and > 0.9 for men; waist: height ≥ 0.5) consumed 450 mL placebo or low calorie, high polyphenol cranberry extract beverage (CEB) daily for 8 week in a randomized, double-blind, placebo-controlled, parallel design trial. Blood and urine samples were collected after overnight fast at baseline and after 8 weeks of daily beverage consumption. Blood and urine samples were also collected during 3 oral glucose tolerance test (OGTT) challenges: (1) pre-intervention without the test beverages, (2) following a single dose of placebo or CEB at baseline (week 0), and (3) following a single dose of placebo or CEB at 8 week. Results Compared to placebo, a single CEB dose at baseline lowered endothelin-1 and elevated nitric oxide and the reduced:oxidized glutathione ratio (P < 0.05). Interferon-γ was elevated (P < 0.05) after a single CEB dose at baseline; however, after 8 week of CEB intervention, fasting C-reactive protein was lower (P < 0.05). CEB consumption for 8 week also reduced serum insulin and increased HDL cholesterol compared to placebo (P < 0.05). Conclusions An acute dose of low calorie, high polyphenol cranberry beverage improved antioxidant status, while 8 week daily consumption reduced cardiovascular disease risk factors by improving glucoregulation, downregulating inflammatory biomarkers, and increasing HDL cholesterol.

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Effects of cranberry juice consumption on vascular function in patients with coronary artery disease

Cited by 229 publications

References 40 publications

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Effect of chokeberry juice consumption on antioxidant capacity, lipids profile and endothelial function in healthy people: a pilot study

Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial

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