Effects of COVID-19 infection on retinal vascular density and choroidal thickness measured by optical coherence tomography angiography

Gokmen, Onur; Ozgur, Gokhan

doi:10.1016/j.pdpdt.2023.103859

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Oren and Kocabas reported that COVID-19 did not affect ACD or pupil diameter 29 . Firat and Kobat and Gokmen and Ozgur reported that CFT and RFT were not affected in patients with recent mild COVID-19 infection 30 , 31 . Thus, to determine whether COVID-19 infection or vaccination modify the clinical features of VKH disease, further study is needed.…”

Section: Discussionmentioning

confidence: 98%

Effect of the COVID-19 pandemic on Vogt–Koyanagi–Harada disease

Muto,

Sakamoto,

Kusuda

et al. 2024

Sci Rep

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To determine the disease prevalence rate and clinical characteristics of Vogt–Koyanagi–Harada (VKH) disease among new patients before and after the declaration of a state of emergency (April 7, 2020) in Japan. New patients and patients with newly diagnosed VKH disease were categorized into “Before” and “After” groups based on the initial visit. The prevalence rate, sex ratio, and age of patients newly diagnosed with VKH were compared between the groups. Best-corrected visual acuity (BCVA) and recurrence rates were compared among 59 patients observed for > 12 months after receiving pulse steroid therapy. For reference, we also examined the prevalence rate of patients newly diagnosed with acute angle closure (AAC) in the Before and After groups. The prevalence rates of VKH disease among newly diagnosed patients (P < 0.05) or patients with AAC (P < 0.001) were significantly higher in the After group. No significant differences in sex ratio or age of VKH disease were observed in both groups. BCVA and recurrence rates showed no significant differences. The COVID-19 pandemic increased the prevalence of VKH disease among new patients compared with that of AAC. However, the clinical features of VKH disease were unlikely affected by the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 98%

Effect of the COVID-19 pandemic on Vogt–Koyanagi–Harada disease

Muto,

Sakamoto,

Kusuda

et al. 2024

Sci Rep

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“…Besides the initially prevalent hallmarks of olfactory and gustatory disorders, and the characteristic memory impairments of the long COVID 6, 11, 12 , ocular manifestations like conjunctivitis, epiphora and retinal lesions have been reported in COVID-19 patients 4, 13–15 . Clinical studies also reported specific impacts in the retina including microhemorrhages, lesions of ischemic pattern, optic nerve thickening and thinning of the retina 4, 14, 16–20 . While Marinho and cols reported lesions in distinct retina layers 4 , another study found retinal alterations in only one of 43 patients infected with SARS-CoV-2 21 .…”

Section: Introductionmentioning

confidence: 99%

Dissecting the ocular impact of SARS-CoV-2 variants: Analysis of eye globe and retina in animal models

da Silva,

Kersten,

Munhóz Dati

et al. 2024

Preprint

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Neurological and ocular manifestations were reported in COVID-19 patients and in SARS-CoV-2 infected animal models. However, the effects of SARS-CoV-2 variants of concern (VoC) on the eyes and the retina remain unclear. Here, we investigate the cellular and molecular consequences of SARS-CoV-2 VoC infection on the eye and retina in mice and hamsters. Infection with the ancestral SARS-CoV-2 and the Gamma VoC induced a subtle increase in the eye volume of K18-hAce2 mice, but no morphological alteration was observed in hamsters’ eyes. Evaluation of the ocular tropism revealed that distinct SARS-CoV-2 VoC reached the eye globe, but not the retina of K18-hAce2 mice. In contrast, SARS-CoV-2 variants are detected in the hamsters’ retina during both acute infection and after disease recovery. Despite the presence of viral RNA, no inflammation was observed in the hamster retina, as evidenced by unchanged microglial cell density and unaltered gene expression of several immune mediators. Altogether, these findings indicate a limited impact of SARS-CoV-2 variants on the eye and retina.

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Effects of COVID-19 infection on retinal vascular density and choroidal thickness measured by optical coherence tomography angiography

Cited by 2 publications

References 22 publications

Effect of the COVID-19 pandemic on Vogt–Koyanagi–Harada disease

Effect of the COVID-19 pandemic on Vogt–Koyanagi–Harada disease

Dissecting the ocular impact of SARS-CoV-2 variants: Analysis of eye globe and retina in animal models

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