Effects of corticosteroid on the expressions of neuropeptide and cytokine mRNA and on tenocyte viability in lateral epicondylitis

Han, Soo-Hong; An, Hee Jung; Song, Ji Ye; Shin, Dong Eun; Kwon, Young Do; Shim, Jong Sup; Lee, Soon Chul

doi:10.1186/1476-9255-9-40

Cited by 23 publications

(15 citation statements)

References 28 publications

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“…Treatment with FP has been demonstrated to reduce the expression of sensory neuropeptides such as substance P and CGRP [26,27] and to inhibit the migration of DC [28]. …”

Section: Introductionmentioning

confidence: 99%

Steroid Treatment Reduces Allergic Airway Inflammation and Does Not Alter the Increased Numbers of Dendritic Cells and Calcitonin Gene-Related Peptide-Expressing Neurons in Airway Sensory Ganglia

Funck²,

Wronski³

et al. 2015

Neuroimmunomodulation

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Objectives: Our previous data demonstrated that allergic airway inflammation induces migration of dendritic cells (DC) into airway sensory jugular and nodose ganglia (jugular-nodose ganglion complex; JNC). Here we investigated the effects of steroid treatment regarding the expression and migration of DC and calcitonin gene-related peptide (CGRP)-immunoreactive neurons of vagal sensory ganglia during allergic airway inflammation. Methods: A house dust mite (HDM) model for allergic airway inflammation was used. The mice received 0.3 mg fluticasone propionate per kilogram of body weight in the last 9 days. JNC slices were analyzed on MHC II, the neuronal marker PGP9.5, and the neuropeptide CGRP. Results: Allergic airway inflammation increased the numbers of DC and CGRP-expressing neurons in the JNCsignificantly in comparison to the controls (DC/neurons: HDM 44.58 ± 1.6% vs. saline 33.29 ± 1.6%, p < 0.05; CGRP-positive neurons/total neurons: HDM 30.65 ± 1.9% vs. saline 19.49 ± 2.3%, p < 0.05). Steroid treatmentdid not have any effect on the numbers of DC and CGRP-expressing neurons in the JNC compared to HDM-treated mice. Conclusions: The present findings indicate an important role of DC and CGRP-containing neurons in the pathogenesis of allergic airway inflammation. However, steroid treatment did not have an effect on the population of DC and neurons displaying CGRP in the JNC, whereas steroid treatment was found to suppress allergic airway inflammation.

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“…Treatment with FP has been demonstrated to reduce the expression of sensory neuropeptides such as substance P and CGRP [26,27] and to inhibit the migration of DC [28]. …”

Section: Introductionmentioning

confidence: 99%

Steroid Treatment Reduces Allergic Airway Inflammation and Does Not Alter the Increased Numbers of Dendritic Cells and Calcitonin Gene-Related Peptide-Expressing Neurons in Airway Sensory Ganglia

Funck²,

Wronski³

et al. 2015

Neuroimmunomodulation

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“…Several explanations for the high recurrence rate exist. First, although CSIs could diminish short‐term pain intensity by inhibiting neuropeptides and cytokines, they also may damage the tenocytes and suppress their viability [60,61]. Second, it is possible that some subjects did not strictly follow the doctor's advice and continued to overuse their elbows because of the temporary pain relief experienced after the corticosteroid injection [62].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Autologous Blood Products Compared With Corticosteroid Injections in the Treatment of Lateral Epicondylitis: A Meta‐Analysis of Randomized Controlled Trials

Qian

Lin

Wei

et al. 2016

PM&R

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Limited evidence supports the conclusion that CSIs are superior to ABPs for pain relief in the short term; however, this result was reversed in the intermediate and long term. ABPs seemed to be more effective at restoring function in the intermediate term. Because of the small sample size and the limited number of high-quality RCTs, more high-quality RCTs with large sample sizes are required to validate this result.

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“…In 2 recently published studies, Lin et al 15 and Nazar et al 20 argued that the percutaneous release of extensor origin on the humeral epicondylitis has a high rate of success without complications. Han et al 9 discussed the possibility that corticosteroids have an inhibitory effect on cytokines and neuropeptides such as CGRP, and that the viability of the tenocytes is compromised. Furthermore, Maher 16 found no evidence of the effectiveness of laser therapy for lateral epicondylitis.…”

Section: Discussionmentioning

confidence: 99%

Medium-Term Results After Treatment of Recalcitrant Lateral Epicondylitis

Meknas

Hassoni

Odden-Miland

et al. 2013

Orthopaedic Journal of Sports Medicine

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Background:Recalcitrant lateral epicondylitis (elbow extensor–origin tendinosis) is a common cause of elbow pain with many treatment options. In the present study, the medium-term results after open release and radiofrequency microtenotomy are reported.Hypothesis:Microtenotomy would provide long-term pain relief that was as good as the open release method.Study Design:Prospective, randomized trial.Methods:Twenty-four patients randomized to either open release or microtenotomy were assessed after 5 to 7 years. Clinical examination and dynamic infrared thermography (DIRT) of both elbows were performed preoperatively and at the medium-term follow-up. Magnetic resonance imaging (MRI) of both elbows was performed at the medium-term follow-up.Results:Significant pain reduction was found using a visual analog scale (VAS) at the medium-term follow-up in both groups compared with the preoperative assessment (P < .005). The Mayo Elbow Performance Score (MEPS) increased significantly in both groups (P < .01). The improvement in grip strength was not significant in either group. There was no significant difference between the groups in terms of VAS, strength, and the MEPS. On the DIRT examinations, there were significantly fewer hot spots at the medium-term follow-up than preoperatively (P = .0067, both study groups together). The MRI examinations revealed grade II changes in the operated elbow in 1 patient in each group at the medium-term follow-up, while all the other MRI examinations revealed a normal tendon.Conclusion:In this prospective, randomized trial with a medium-term follow-up, the results were similar after surgical release and microtenotomy in patients with recalcitrant lateral epicondylitis. The hypothesis was thus verified.

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Effects of corticosteroid on the expressions of neuropeptide and cytokine mRNA and on tenocyte viability in lateral epicondylitis

Cited by 23 publications

References 28 publications

Steroid Treatment Reduces Allergic Airway Inflammation and Does Not Alter the Increased Numbers of Dendritic Cells and Calcitonin Gene-Related Peptide-Expressing Neurons in Airway Sensory Ganglia

Steroid Treatment Reduces Allergic Airway Inflammation and Does Not Alter the Increased Numbers of Dendritic Cells and Calcitonin Gene-Related Peptide-Expressing Neurons in Airway Sensory Ganglia

Efficacy and Safety of Autologous Blood Products Compared With Corticosteroid Injections in the Treatment of Lateral Epicondylitis: A Meta‐Analysis of Randomized Controlled Trials

Medium-Term Results After Treatment of Recalcitrant Lateral Epicondylitis

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