Effects of copper toxicity on growth, reproduction and metal accumulation in chosen ornamental fishes

James, R; Sampath, K; Jothilakshmi, Shellam; Vasudhevan, Iyyadurai; Thangarathinam, Ramasamy

doi:10.2478/v10104-009-0007-y

Cited by 23 publications

(8 citation statements)

References 10 publications

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“…Recently, aquatic organisms may suffer from exposure to Cu concentrations that might be ten to fifty times higher than the required concentrations (10) . The danger of Cu is aggravated by their almost indefinite persistence in water because they cannot be destroyed biologically but are only transformed from one state to another (11) . Also, high concentrations of waterborne Cu can be toxic, because perturbations in Cu homoeostasis result in oxidative stress and increased free-radical production (12)(13)(14) .…”

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confidence: 99%

Glutamate ameliorates copper-induced oxidative injury by regulating antioxidant defences in fish intestine

Jiang

Zhou

et al. 2016

Br J Nutr

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The objective of this study was to determine the protective effect of glutamate (Glu) in Cu-induced oxidative injury in fish intestine in vivo and enterocytes in vitro. The results indicated that exposure to 6 mg/l Cu for 72 h induced the production of reactive oxygen species, thereby increasing protein oxidation and lipid peroxidation in enterocytes of grass carp in vitro. Cells exposed to Cu alone resulted in a significant increase in lactate dehydrogenase release, which is accompanied by depletions of antioxidants, including total superoxide dismutase (T-SOD), glutathione S-transferase (GST), glutathione reductase (GR), anti-superoxide anion (ASA), anti-hydroxy radical (AHR) activities and GSH content. Pre-treatment with Glu remarkably prevented the toxic effects of Cu on the T-SOD, GST, GR, AHR, and ASA activities and GSH content in enterocytes. However, Cu induced an adaptive increase in the activities of catalase and glutathione peroxidase (GPx). Glu supplementation further increased GPx activity in enterocytes. Interestingly, the experiment in vivo showed that Glu pre-supplementation significantly elevated SOD, GPx, GST, GR, ASA and AHR activities, as well as GSH content. Further results showed that pre-treatment with Glu could alleviate Cu-induced oxidative injury by elevating antioxidant enzyme activities through regulating the expression of NF-E2-related nuclear factor 2 (Nrf2) mRNA. Together, these results indicated that Glu could attenuate Cu-induced cellular oxidative damage in fish intestine, likely mediated through Nrf2 signalling pathways regulating mRNA expressions of antioxidant enzyme genes and synthesis of GSH.

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confidence: 99%

Glutamate ameliorates copper-induced oxidative injury by regulating antioxidant defences in fish intestine

Jiang

Zhou

et al. 2016

Br J Nutr

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“…However at higher concentrations free cupric ions have been indicated as the most toxic forms of Cu present in the aquatic environment for marine organisms (Nor 1987), as they are supposed to damage intracellular proteins which lead towards apoptotic cell death (Monteiro et al 2009). Other studies (USEPA 1985;James et al 2008;Jorge et al 2013) revealed a strong correlation between the concentration of Cu in the water body and physiological changes such as a lag in growth in the organisms they studied. Further, Cu can influence negatively the reproduction process of different marine organisms (USEPA 1985;James et al 2008) as well as the community structure of phyto -and zooplankton (Moore and Winner 1989).…”

Section: Effects Of Copper On Organismsmentioning

confidence: 80%

“…Other studies (USEPA 1985;James et al 2008;Jorge et al 2013) revealed a strong correlation between the concentration of Cu in the water body and physiological changes such as a lag in growth in the organisms they studied. Further, Cu can influence negatively the reproduction process of different marine organisms (USEPA 1985;James et al 2008) as well as the community structure of phyto -and zooplankton (Moore and Winner 1989). However, Jorge et al (2013) have verified adaptive or compensatory mechanisms when organisms are exposed even to higher concentrations of Cu for longer terms.…”

Section: Effects Of Copper On Organismsmentioning

confidence: 80%

Harmful Elements in Estuarine and Coastal Systems

Khan

Masiol

Hofer

et al. 2014

PHEs, Environment and Human Health

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Estuaries and coastal zones are dynamic transitional systems which provide many economic and ecological benefits to humans, but also are an ideal habitat for other organisms as well. These areas are becoming contaminated by various anthropogenic activities due to a quick economic growth and urbanization. This chapter explores the sources, chemical speciation, sediment accumulation and removal mechanisms of the harmful elements in estuarine and coastal seawaters. It also describes the effects of toxic elements on aquatic flora and fauna. Finally, the toxic element pollution of the Venice Lagoon, a transitional water body located in the northeastern part of Italy, is discussed as a case study, by presenting the procedures adopted to measure the extent of the pollution, the impacts on organisms and the restoration activities.

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“…A study demonstrated that copper accumulation in gonad tissue of Carassius carassius auratus and Xiphophorus helleri increased linearly with the increase in sublethal levels of copper over a given period of exposure. Simultaneously, there was a reduction in the growth rate and reproductive performance in tested fishes [ 103 ]. In the same study, decreases in the mean diameter of eggs of Carassius auratus and the mean weight and body length of Xiphophorus helleri were reported.…”

Section: Overview Of Copper-induced Organ Toxicity In Elected Fishmentioning

confidence: 99%

Review of Copper and Copper Nanoparticle Toxicity in Fish

et al. 2020

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This review summarizes the present knowledge on the toxicity of copper and copper nanoparticles (CuNPs) to various fish species. In previous decades, the excessive usage of metal and metallic nanoparticles has increased significantly, increasing the probability of the accumulation and discharge of metals in various trophic levels of the environment. Due to these concerns, it is important to understand the toxicity mechanisms of metals and metallic nanoparticles before they lead to unhealthy effects on human health. In this review paper, we specifically focus on the effect of metal copper and CuNPs on different fish organs under different physiochemical parameters of various water bodies. Nowadays, different forms of copper have distinctive and specific usages, e.g., copper sulfate is a well-established pesticide which is used to control the growth of algae in lakes and ponds. Deactivating the fungi enzymes prevents fungal spores from germinating. This process of deactivation is achieved via the free cupric ions, which are established as the most toxic forms of copper. Complexes of copper with other ligands may or may not be bioavailable for use in aquatic organisms. On the other hand, CuNPs have shown cost-effectiveness and numerous promising uses, but the toxicity and availability of copper in a nanoparticle form is largely unknown, Additionally, physiochemical factors such as the hardness of the water, alkalinity, presence of inorganic and organic ligands, levels of pH, and temperature in various different water bodies affect the toxicity caused by copper and CuNPs. However, comprehensive knowledge and data regarding the pattern of toxicity for copper metal ions and CuNPs in marine organisms is still limited. In this review, we carry out a critical analysis of the availability of the toxicological profiles of copper metal ions and CuNPs for different fishes in order to understand the toxicity mechanisms of copper and CuNPs. We believe that this review will provide valuable information on the toxicological profile of copper, which will further help in devising safe guidelines for the usage of copper and CuNPs in a sustainable manner.

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Effects of copper toxicity on growth, reproduction and metal accumulation in chosen ornamental fishes

Cited by 23 publications

References 10 publications

Glutamate ameliorates copper-induced oxidative injury by regulating antioxidant defences in fish intestine

Glutamate ameliorates copper-induced oxidative injury by regulating antioxidant defences in fish intestine

Harmful Elements in Estuarine and Coastal Systems

Review of Copper and Copper Nanoparticle Toxicity in Fish

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