Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension

Dohadwala, Mustali M; Hamburg, Naomi M.; Holbrook, Monika; Kim, Brian H; Duess, Mai‐Ann; Levit, Aaron; Titas, Megan; Chung, William; Vincent, Felix B; Caiano, Tara; Frame, Alissa A.; Keaney, John F.; Vita, Joseph A.

doi:10.3945/ajcn.2010.29905

Cited by 71 publications

(85 citation statements)

References 36 publications

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“…However, consumption of grape juice for 8 weeks by human subjects with pre-hypertension or Stage 1 hypertension, did not experience lowering of BP (Dohadwala et al, 2010) whereas an 8 week study of grape juice consumption by Korean hypertensive men indicated favourable lowering of BP (Park, Kim, & Kang, 2004). These results may suggest that as proposed for tea (Dong et al, 2011), process-mediated enrichment of the efficacious fraction may be required for demonstrable in vivo effect.…”

Section: Ace Regulation By Dietary Plantscontrasting

confidence: 46%

Processed dietary plants demonstrate broad capacity for angiotensin converting enzyme and angiotensin II receptor binding inhibition in vitro

Patten

Abeywardena

Head

et al. 2012

Journal of Functional Foods

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Section: Ace Regulation By Dietary Plantscontrasting

confidence: 46%

Processed dietary plants demonstrate broad capacity for angiotensin converting enzyme and angiotensin II receptor binding inhibition in vitro

Patten

Abeywardena

Head

et al. 2012

Journal of Functional Foods

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“…Seven trials [14], [17], [21], [25], [24], [29], [30] were classified as high quality (Jadad score ≥4) and the remaining 12 trials were low quality (Jadad score <4). All 7 high-quality trials had adequate allocation concealment (i.e., conducted by a third-party manufacturer or using opaque envelopes) and 2 high-quality trials reported the generation of random numbers or randomization list.…”

Section: Resultsmentioning

confidence: 99%

Effect of Fruit Juice on Cholesterol and Blood Pressure in Adults: A Meta-Analysis of 19 Randomized Controlled Trials

Xing

Chen

et al. 2013

PLoS ONE

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BackgroundThe effect of fruit juice on serum cholesterol and blood pressure in humans has generated inconsistent results. We aimed to quantitatively evaluate the effect of fruit juice on serum cholesterol and blood pressure in adults.MethodsWe performed a strategic literature search of PubMed, EMBASE, and the Cochrane Library (updated to October, 2012) for randomized controlled trials that evaluated the effects of fruit juice on serum cholesterol and blood pressure. Study quality was assessed by using the Jadad scale. Weighted mean differences were calculated for net changes in cholesterol and blood pressure by using fixed-effects model. Prespecified subgroup and sensitivity analyses were conducted to explore the potential heterogeneity.ResultsNineteen trials comprising a total of 618 subjects were included in this meta-analysis. Fruit juice consumption borderlinely reduced the diastolic blood pressure (DBP) by 2.07 mm Hg (95% CI: −3.75, −0.39 mm Hg; p = 0.02), but did not show significant effects on total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) concentrations or systolic blood pressure (SBP) values. A significant reduction of TC concentration was observed in low-median intake of total polyphenols group. Subgroup analyses for HDL-C and LDL-C concentrations did not show statistically significant results. No significant heterogeneity was detected for all the measures.ConclusionThis meta-analysis suggested that fruit juice had a borderline significant effect on reducing DBP, but had no effect on TC, HDL-C, LDL-C concentrations or SBP.

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“…In contrast, red wine with and without alcohol decreased both DBP and SBP in clinical studies conducted on a population at high cardiovascular risk (Chiva-Blanch et al, 2012), while consumption of grape polyphenol powder significantly reduced only SBP (Barona et al, 2012). Resveratrol (10 mg) consumed by subjects with a history of cardiovascular disease significantly improved left ventricular diastolic pressure (Magyar et al, 2012), but recent studies that included subjects with prehypertension and mild hypertension showed that the consumption of red wine polyphenols, grape juice or grape seed extract had no effect on BP (Botden et al, 2012;Dohadwala et al, 2010;Ras et al, 2013).…”

Section: Discussionmentioning

confidence: 95%

Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: a double blind, placebo-controlled, randomized study

Vaisman

Niv

2015

International Journal of Food Sciences and Nutrition

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Consumption of polyphenol-rich food and food ingredient such as grape and grape products improved various cardiovascular parameters. In this study, we investigate the effect of dietary daily consumption of red grape cell powder (RGC) on blood pressure (BP) and flow-mediated dilatation (FMD) as well as on oxidative stress in 50 subjects with prehypertension and mild hypertension. The subjects were randomized into groups that consumed 200, 400 mg RGC or placebo daily for 12 weeks. RGC consumption was associated with an improvement of FMD (p = 0.013). There was a significant decrease in lipid peroxidation (p = 0.013) after 12 weeks in a combined RGC-treated group. The diastolic BP decreased significantly in the 200 mg RGC group compared to the placebo group (p = 0.032). Our results indicate that a daily supplementation, of red grape cell powder, for 12 weeks affects endothelial function, diastolic BP and oxidative stress without any adverse effects.

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Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension

Cited by 71 publications

References 36 publications

Processed dietary plants demonstrate broad capacity for angiotensin converting enzyme and angiotensin II receptor binding inhibition in vitro

Processed dietary plants demonstrate broad capacity for angiotensin converting enzyme and angiotensin II receptor binding inhibition in vitro

Effect of Fruit Juice on Cholesterol and Blood Pressure in Adults: A Meta-Analysis of 19 Randomized Controlled Trials

Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: a double blind, placebo-controlled, randomized study

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