Effects of combined exposure to formaldehyde and benzene on immune cells in the blood and spleen in Balb/c mice

Wen, Huaxiao; Yuan, Langyue; Wei, Chenxi; Zhao, Yun; Qian, Yan; Ma, Ping; Ding, Shuzhe; Yang, Xu; Wang, Xianliang

doi:10.1016/j.etap.2016.05.007

Cited by 43 publications

(25 citation statements)

References 24 publications

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“…Матлина [7]. Был применен триоксииндоловый флуори-метрический метод определения адреналина (А), норадреналина (НА), дофамина (ДА) и ди-оксифенилаланина (ДОФА) в одной порции мо-чи [13]. Для выяснения состояния свертываю-щей системы крови определялось время свер-тывания крови (ВСК), ретракция кровяного сгустка (РКС), время рекальцификации плазмы (ВРП), толерантность плазмы к гепарину (ТПГ), протромбиновое время и протромбиновый ин-декс, концентрация фибриногена, фибриноли-тическая активность крови (ФА) [1,6].…”

Section: __________________________unclassified

“…в больших концентрациях действует на цен-тральную нервную систему (ЦНС) как нарко-тик, а при хроническом действии малых доз -становится ядом крови и кроветворных органов [13,14,17]. Также известно, что в зависимости от концентрации бензол, попадая в организм, может приводить к различным патологическим реакциям.…”

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“…Режим повышающихся концентраций соз-давался путем введения в камеру по 0,25 поро-говой концентрации каждые 15 минут, учиты-вая, что порог вредного действия бензола со-ставляет 2000 мг/м 3 [13]. При режиме колеблющихся концентраций бензол в камеру подавался через 30 мин в таком количестве, чтобы концентрации резко колеба-лись.…”

unclassified

“…4). Результаты наших исследований и работы других ученых [8,12,13,17] показывают, что первичная реакция организма на токсическое действие бензола проявляется со стороны систе-мы периферической крови, которая в свою оче-редь дает информацию о состоянии симпатиче-ской нервной системы. Следовательно, первичная реакция организма на эндогенное раздражение выражается в возбуждении симпатической нерв-ной системы с соответствующим повышением симпатической активности крови.…”

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Changes in the Nervous System State and Peripheral Blood Parameters Under Benzene Intoxication During an Experiment

Orujov¹,

Dzhafarova²

2017

Health Risk Analysis

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Ключевые слова : затравка бензолом, интоксикация, нервная система, наркотическое состояние, гемато-грамма, катехоламины, ацетилхолин, холинэстеразы. Предприятия нефтеперерабатывающей и нефтехимической промышленности с гигиени-ческой точки зрения характеризуются наличи-ем в воздухе рабочей зоны многочисленных потенциально опасных веществ, являющихся химическими факторами риска как для здоро-вья работников этих предприятий, так и для всего населения [12,15].Среди продукции нефтехимической про-мышленности наиболее широко применяемыми считаются бензин, ацетон и бензол. Самый ток-сичный из них -бензол [5, 10]. Это вещество __________________________

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Changes in the Nervous System State and Peripheral Blood Parameters Under Benzene Intoxication During an Experiment

Orujov¹,

Dzhafarova²

2017

Health Risk Analysis

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“…After the oxidative damage caused by lipid peroxidation and protein biotransformation presented by individuals exposed to FA, there was recruitment of inflammatory cells [15]. In addition to the lungs, FA induced oxidative stress in the uterus and spleen [16–18]. Repeated treatments with 50 μ M FA changed the expression of more than 100 liver genes, showing that repeated inhalation of FA has widespread effects on major organs [19].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats

Tang

Rong

et al. 2017

BioMed Research International

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Formaldehyde (FA) is an occupational and indoor pollutant. Long-term exposure to FA can irritate the respiratory mucosa, with potential carcinogenic effects on the airways. The effects of acute FA poisoning on the activities of CYP450 isoforms CYP1A2, CYP2C11, CYP2E1, and CYP3A2 were assessed by determining changes in the pharmacokinetic parameters of the probe drugs phenacetin, tolbutamide, chlorzoxazone, and testosterone, respectively. Rats were randomly divided into three groups: control, low FA dose (exposure to 110 ppm for 2 h for 3 days), and high FA dose (exposure to 220 ppm for 2 h for 3 days). A mixture of the four probe drugs was injected into rats and blood samples were taken at a series of time points. Plasma concentrations of the probe drugs were measured by HPLC. The pharmacokinetic parameters t1/2, AUC(0−t), and Cmax of tolbutamide, chlorzoxazone, and testosterone increased significantly in the high dose versus control group (P < 0.05), whereas the CL of chlorzoxazone and testosterone decreased significantly (P < 0.05). However, t1/2, AUC(0−t), and Cmax of phenacetin decreased significantly (P < 0.05), whereas the CL of phenacetin increased significantly (P < 0.05) compared to controls. Thus, acute FA poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats. And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways.

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Immunotoxicology in Industrial Hygiene and Occupational Exposures

2023

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Immunotoxicology is the study of drugs and chemicals that produce adverse effects on the immune system. Adverse immune effects include suppression, leading to compromised ability to fight infections, or enhancement, which could be involved in hypersensitivity (allergy) or autoimmunity. It has been appreciated for hundreds of years that diseases are associated with various occupations, such as respiratory diseases in those working with grains, coal, metals, or animals. We now understand that many of these occupational diseases are the result of an unregulated immune response to a specific agent. Similarly, occupational exposures to various chemicals can produce dermatitis, again due in part to unregulated immune responses in the skin. Additionally, occupational chemical exposures have been demonstrated to induce immune suppression. This chapter provides an overview of the immune system, a synopsis of standard assays to evaluate immunotoxic potential of occupational chemicals, and descriptions of effects of several occupational immunotoxicants with a focus on human exposures and doses. Consideration is given to current data gaps and potential use of novel technologies to more precisely define effects and mechanisms of occupational immunotoxicants.

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Effects of combined exposure to formaldehyde and benzene on immune cells in the blood and spleen in Balb/c mice

Cited by 43 publications

References 24 publications

Changes in the Nervous System State and Peripheral Blood Parameters Under Benzene Intoxication During an Experiment

Changes in the Nervous System State and Peripheral Blood Parameters Under Benzene Intoxication During an Experiment

The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats

Immunotoxicology in Industrial Hygiene and Occupational Exposures

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