Effects of Collagen Peptide Ingestion on Blood Lipids in Rats Fed a High-Lipid and High-Sucrose Diet

Koyama, Yoh-ichi; Kusubata, Masashi

doi:10.3136/fstr.19.1149

Cited by 10 publications

(11 citation statements)

References 18 publications

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“…1(A-C)). This is consistent with previous studies that examined the lipid-lowering effects of collagen ingestion in humans and animals (3,(11)(12)(13)(14)(15) . In the present study, significant differences were observed neither in the level of blood TAG nor in liver lipid contents, although our DNA microarray data suggest that liver lipid metabolism is enhanced by CP ingestion.…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, significant differences were observed neither in the level of blood TAG nor in liver lipid contents, although our DNA microarray data suggest that liver lipid metabolism is enhanced by CP ingestion. Similar results that reduction in blood cholesterol without changes in TAG were also observed in our previous study in rats ( 14 ) . On the other hand, there are several reports that serum TAG is reduced by CP ingestion ( 11 , 13 ) , and one explanation for the reduction is described as increase in faecal excretion ( 13 ) .…”

Section: Discussionsupporting

confidence: 92%

“…Collagen ingestion suppresses the activity of angiotensin I-converting enzyme, resulting in decreased blood pressure ( 9 , 10 ) . Ingestion of collagen also reportedly modulates blood lipid profiles in rats ( 3 , 11 , 12 , 14 ) , mice ( 13 ) and rabbits ( 15 ) ; TAG and/or total cholesterol levels are markedly reduced in these animals when fed a CP-containing diet. It has been expected that the ingestion of collagen, which has been shown to elicit effects in various parts of the body ( 2 – 15 ) , likely affects the liver, which is involved in various biological functions including lipid metabolism, detoxification, protein synthesis, hormone production and production of biochemicals necessary for digestion ( 16 ) .…”

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confidence: 99%

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Collagen peptide ingestion alters lipid metabolism-related gene expression and the unfolded protein response in mouse liver

et al. 2017

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Ingestion of collagen peptide (CP) elicits beneficial effects on the body, including improvement in blood lipid profiles, but the underlying mechanisms remain unclear. The purpose of this study was to investigate the effects of CP ingestion on the liver, which controls lipid metabolism in the body. Male BALB/cCrSlc mice were bred with the AIN-93M diet containing 14 % casein or the AIN-93M-based low-protein diet containing 10 % casein or a diet containing 6 % casein+4 % CP for 10 weeks (n 12/group). Total, free and esterified cholesterol levels in the blood decreased in the CP group. DNA microarray analysis of the liver revealed that expressions of genes related to lipid metabolic processes such as the PPAR signalling pathway and fatty acid metabolism increased in the CP group compared with the 10 % casein group. The expressions of several genes involved in steroid metabolic process, including Cyp7a1 and Cyp8b1, were decreased, despite being targets of transcriptional regulation by PPAR. These data suggest that lipid metabolism in the liver is altered by CP ingestion, and the decrease in blood cholesterol levels in the CP group is not due to enhancement of the steroid metabolic process. On the other hand, expressions of genes related to the unfolded protein response (UPR) significantly decreased at the mRNA level, suggesting that CP ingestion lowers endoplasmic reticulum stress. Indeed, protein levels of phosphorylated inositol-requiring enzyme 1 decreased after CP ingestion. Taken together, CP affects the broader pathways in the liver - not only lipid metabolism but also UPR.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

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confidence: 99%

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Collagen peptide ingestion alters lipid metabolism-related gene expression and the unfolded protein response in mouse liver

et al. 2017

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“…The Col-Pep groups were administered food containing 0.15% or 0.3% Col-Pep (MW: 4,000–6,000; nitrogen content: 16.9%; fish-derived; Nippi Inc., Tokyo, Japan) such that a daily Col-Pep intake of 0.1 or 0.2 g/kg body weight was attained in the finisher period, respectively. The dose of 0.2 g/kg body weight was selected based on the effect reported in the porcine skin (62-day intake), the mouse skin (56-day intake), human skin (42-day intake), the rabbit Achilles tendon (56-day intake) and the rat blood lipids (29-day intake) [ 9 , 10 , 13 , 14 , 21 ]. To examine whether the effect of Col-Pep ingestion was collagen-specific or caused by ingestion of protein in general, the crude protein levels were adjusted to approximately equal amounts (days 0–21: 23.5%; days 22–49: 18.0%) using maize (Marui-Sangyo Co., Ltd., Nagano, Japan).…”

Section: Methodsmentioning

confidence: 99%

Oral ingestion of collagen peptide causes change in width of the perimysium of the chicken iliotibialis lateralis muscle

Watanabe

Nishimura

Takeuchi

et al. 2015

The Journal of Veterinary Medical Science

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Skeletal muscle is mainly composed of myofibers and intramuscular connective tissue. Bundles composed of many myofibers, with each myofiber sheathed in connective tissue called the endomysium, are packed in the perimysium, which occupies the vast bulk of the intramuscular connective tissue. The perimysium is a major determination factor for muscle texture. Some studies have reported that collagen peptide (Col-Pep) ingestion improves the connective tissue architecture, such as the tendon and dermis. The present study evaluated the effects of Col-Pep ingestion on the chicken iliotibialis lateralis (ITL) muscle. Chicks were allocated to three groups: the 0.15% or 0.3% Col-Pep groups and a control group. Col-Pep was administered by mixing in with commercial food. On day 49, the ITL muscles were analyzed by morphological observation and the textural property test. The width of the perimysium in the 0.3% Col-Pep group was significantly larger than other two groups. Although scanning electron microscopic observations did not reveal any differences in the architecture of the endomysium, elastic improvement of the ITL muscle was observed as suggested by an increase of the width of perimysium and improved rheological properties. Our results indicate that ingestion of Col-Pep improves the textural property of ITL muscle of chickens by changing structure of the perimysium.

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“…However, this method has several side effects such as pain, erythema, and an infectious granulomatous reaction (15,16). Alternatively, several natural polymers including low-molecular-weight chitosan, gelatin, and chondroitin sulfate have been used as dietary supplements to accelerate fat reduction through several pathways (17–19). Gelatin is an inexpensive alternative, readily available in nature, and widely used in diverse biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue

Kim

Seong

et al. 2019

ToxicolRes

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Subcutaneous adipose tissue (SAT) accumulation is a constitutional disorder resulting from metabolic syndrome. Although surgical and non-surgical methods for reducing SAT exist, patients remain non-compliant because of potential adverse effects and cost. In this study, we developed a new minimally-invasive approach to achieve SAT reduction, using a microneedle (MN) patch prepared from gelatin, which is capable of regulating fat metabolism. Four gelatin types were used: three derived from fish (SA-FG, GT-FG 220, and GT-FG 250), and one from swine (SM-PG 280). We applied gelatin-based MN patches five times over 4 weeks to rats with high-fat diet (HD)-induced obesity, and determined the resulting amount of SAT. We also investigated the histological features and determined the expression levels of fat metabolism-associated genes in SAT using hematoxylin and eosin staining and western blotting, respectively. SAT decreased following treatment with all four gelatin MN patches. Smaller adipocytes were observed in the regions treated with SA-FG, GT-FG 250, and SM-PG 280 MNs, demonstrating a decline in fat accumulation. The expression levels of fat metabolism-associated genes in the MN-treated SAT revealed that GT-FG 220 regulates fatty acid synthase (FASN) protein levels. These findings suggest that gelatin MN patches aid in decreasing the quantity of unwanted SAT by altering lipid metabolism and fat deposition.

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Effects of Collagen Peptide Ingestion on Blood Lipids in Rats Fed a High-Lipid and High-Sucrose Diet

Cited by 10 publications

References 18 publications

Collagen peptide ingestion alters lipid metabolism-related gene expression and the unfolded protein response in mouse liver

Collagen peptide ingestion alters lipid metabolism-related gene expression and the unfolded protein response in mouse liver

Oral ingestion of collagen peptide causes change in width of the perimysium of the chicken iliotibialis lateralis muscle

Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue

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