Effects of Collagen Peptide Ingestion on UV-B-Induced Skin Damage

Tanaka, Midori; Koyama, Yoh-ichi; Nomura, Yasuya

doi:10.1271/bbb.80649

Cited by 148 publications

(119 citation statements)

References 11 publications

(10 reference statements)

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…CP ingestion also improves the mechanical properties of the Achilles tendon (Minaguchi et al, 2005) and the skin (Matsuda et al, 2006). Skin damage induced by repeated UVB irradiation in mice is suppressed by CP ingestion (Tanaka et al, 2009). Brittle nails are improved (Rosenburg et al, 1957), and hair diameter increases following the ingestion of gelatin (Scala et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

Effects of Collagen-Derived Oligopeptide Prolylhydroxyproline on Differentiation of Mouse 3T3-L1 Preadipocytes

Minaguchi

Tometsuka

Koyama

et al. 2012

FSTR

Self Cite

View full text Add to dashboard Cite

Beneficial effects of collagen peptide ingestion to reduce serum triacylglycerides have been reported, suggesting that the physiological conditions of adipocytes are modulated following collagen peptide ingestion. In this study, the effects of prolylhydroxyproline, a major digestive product of ingested collagen peptide in the blood, on the differentiation of mouse 3T3-L1 preadipocytes in vitro were investigated. 3T3-L1 preadipocytes were induced to differentiate to adipocytes and treated with prolylhydroxyproline, or with an amino acid mixture of proline and hydroxyproline as a control. The amount of lipid was not affected by these treatments. However, the size of the lipid droplet was significantly smaller when treated with prolylhydroxyproline compared to the amino acid mixture or the non-treated control. Proton-coupled oligopeptide transporters were expressed in non-differentiated and/or differentiated 3T3-L1 cells. These results suggest that prolylhydroxyproline might modulate the morphology of lipid droplets by incorporation into adipocytes through the transporters.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Collagen-Derived Oligopeptide Prolylhydroxyproline on Differentiation of Mouse 3T3-L1 Preadipocytes

Minaguchi

Tometsuka

Koyama

et al. 2012

FSTR

Self Cite

View full text Add to dashboard Cite

show abstract

“…이전의 연구에서 부산 물인 Labeo rohita, Catla catla, Pogonias cromis, Archosargus probatocephalus, Lates calcarifer 등 각종 어류 비늘을 이용하여 단 백질, 콜라겐, 아미노산 등 유용한 물질들이 확인되었다 [17,21,22,25]. 그리고 Tilapia zillii의 비늘 추출물에서 콜라겐 펩타 이드 성분이 UVB로 유도된 피부 손상을 억제하였다 [27]. 또 한, Otolithes ruber 추출 펩타이드에서 항 산화 효과가 보고되 었다 [18].…”

Section: 서 론unclassified

Peptides-derived from Scales of Branchiostegus japonicus Inhibit Ultraviolet B-induced Oxidative Damage and Photo-aging in Skin Cells

오민창¹,

김기천²,

고창익³

et al. 2015

Journal of Life Science

View full text Add to dashboard Cite

Collagen peptides, which are found at high concentrations in the human body, are present in animal bones and the skin of marine organisms, namely, fish scales. Collagen is the most abundant structural protein of various connective tissues in animals. Furthermore, it is widely used in biomedical material, pharmaceutical, cosmetic, food, and leather industries. Peptides extracted from scales of various fish protect against ultraviolet B (UVB)-induced skin damage and photo-aging. However, the protective effects of collagen peptides derived from the scales of Branchiostegus japonicus against UVB exposure are unclear. This study investigated the effects of peptides larger than 1 kDa (high-molecular weight peptides [HMP]) and smaller than 1 kDa (low-molecular weight peptides [LMP]), derived from extracts of B. japonicus scales, against UVB-induced skin damage and photo-aging. These peptides scavenged 1,1-diphenyl-2-picrylhydrazyl radicals in a dose-dependent manner. In UVB-exposed HaCaT human keratinocytes, LMP inhibited 8-isoprostane generation, a marker of cellular lipid peroxidation. The peptides also suppressed the UVB-induced increase in tyrosinase activity and melanin content in B16F10 mouse melanoma cells. In addition, the LMP and HMP treatment suppressed UVB-induced elastase and matrix metalloproteinase-1 activities in the HaCaT cells. These results indicate that peptides derived from B. japonicus scales have antioxidant, antiphoto-aging, and skin-whitening effects.

show abstract

“…For example, the effects of the oral intake of various compounds in defense against skin damage caused by UV have been examined. Oral administration of collagen peptide was reported to induce an increase in fibroblast density and to enhance the formation of dermal collagen fibrils in piglet skin (4), as well as to suppress the UVB-induced decreases in skin hydration, epidermal hypertrophy, and amount of soluble type I collagen in mouse skin (5). Oral intake of soy isoflavones was shown to suppress UVB-induced matrix metalloproteinase expression and the subsequent collagen degradation in mouse skin (6).…”

Section: Introductionmentioning

confidence: 99%

Anti-aging effects of high molecular weight proteoglycan from salmon nasal cartilage in hairless mice

et al. 2012

View full text Add to dashboard Cite

Abstract. Proteoglycans comprise a family of complex macromolecules consisting of a core protein with covalently attached glycosaminoglycan (GAG) chains. The skin antiaging effects of oral administration of proteoglycan fractions with different molecular weights from salmon nasal cartilage were investigated in a hairless mouse model of skin aging; aging was caused by repeated ultraviolet B (UVB) irradiation. Three proteoglycan fractions of different molecular weights were prepared from salmon nasal cartilage water extract by ion-exchange column chromatography and gel filtration column chromatography. Physiological and histological analysis of the skin indicated that oral administration of high molecular weight proteoglycan inhibited UVB-induced skin aging, defined as increased erythema, increased transepidermal water loss (TEWL), decreased hydration, and epidermal and dermal hypertrophies. The serum and dorsal skin inflammatory cytokine levels indicated that high molecular weight proteoglycan acts on gut immunity and improves skin by inhibiting surplus inflammatory cytokines produced by UVB irradiation. These results suggest that high molecular weight proteoglycan from salmon nasal cartilage is effective in preventing skin aging.

show abstract

Effects of Collagen Peptide Ingestion on UV-B-Induced Skin Damage

Cited by 148 publications

References 11 publications

Effects of Collagen-Derived Oligopeptide Prolylhydroxyproline on Differentiation of Mouse 3T3-L1 Preadipocytes

Effects of Collagen-Derived Oligopeptide Prolylhydroxyproline on Differentiation of Mouse 3T3-L1 Preadipocytes

Peptides-derived from Scales of Branchiostegus japonicus Inhibit Ultraviolet B-induced Oxidative Damage and Photo-aging in Skin Cells

Anti-aging effects of high molecular weight proteoglycan from salmon nasal cartilage in hairless mice

Contact Info

Product

Resources

About