volume 93, issue 0, P3-P-269 2020
DOI: 10.1254/jpssuppl.93.0_3-p-269
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Abstract: We have recently found that CNB-001, a synthetic curcumin derivative, suppresses thrombin-induced nitric oxide (NO) production in cultured microglia, demonstrating that it exerts anti-neuroinflammatory effects by regulating microglial activation. In the present study, we investigated the molecular mechanisms underlying the suppressive effects of CNB-001 on thrombin-induced inflammatory responses. Western blotting analysis demonstrated that thrombin (10 U/mL) induced rapid phosphorylation of extracellular signa…

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