Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats

Effects of Dexmedetomidine Pretreatment on Bupivacaine Cardiotoxicity in Rats

“…13 Bupivacaine induces several electrophysiologic and hemodynamic disturbances, by causing cardiac conduction blocks, and arrhythmias that can lead to cardiovascular collapse and cardiac arrest. 1,13 De La Coussaye et al 3 demonstrated that the combination of clonidine and dobutamine could reverse both the hemodynamic and the electrophysiologic cardiotoxic effects of bupivacaine in anesthetized dogs. Similarly, De Kock et al 4 showed that pretreatment with clonidine significantly reduced the cardiotoxicity caused by administration of bupivacaine.…”

“…In a previous report comparing saline and clonidine pretreatment in the prevention of bupivacaine-induced cardiotoxicity in rats, the investigators used the same primary outcome as was used in this study. 1 On the basis of these data, 1 to achieve a power of 98% and setting 0.05 as the level of significance, we calculated that it was necessary to include 8 rats in each group.…”

“…B upivacaine is a common local anesthetic agent that is widely used in regional anesthesia. 1,2 Unintentional intravenous injection of an overdose of bupivacaine may lead to serious systemic adverse effects and can cause central nervous system dysfunction, such as convulsions, and cardiotoxic effects, such as severe arrhythmias and cardiac arrest. 1,2 Use of the > 2adrenoceptor agonist clonidine has been shown to have protective effects against bupivacaine cardiotoxicity.…”

“…1,2 Unintentional intravenous injection of an overdose of bupivacaine may lead to serious systemic adverse effects and can cause central nervous system dysfunction, such as convulsions, and cardiotoxic effects, such as severe arrhythmias and cardiac arrest. 1,2 Use of the > 2adrenoceptor agonist clonidine has been shown to have protective effects against bupivacaine cardiotoxicity. 3,4 Dexmedetomidine is a highly selective > 2 -adrenoceptor agonist that can be used as an intraoperative sedative or as an adjuvant medication to local anesthetics during regional anesthetic procedures.…”

Anaesthetic efficacy of lidocaine/clonidine for inferior alveolar nerve block in patients with irreversible pulpitis

“…, Gulec et al . ), and enhanced anaesthesia when combined with local anaesthetics (Bajwa et al . , Singh et al .…”