Effects of cisplatin and thiosulfate upon auditory brainstem responses of guinea pigs

Otto, W. C.; Brown, Ronald D.; Gage‐White, Linda; Kupetz, S A; Anniko, Matti; Penny, J. E.; Henley, Charles M.

doi:10.1016/0378-5955(88)90042-1

Cited by 78 publications

(33 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is consistent with past human (e.g., Blakley and Myers 1993;Madasu et al 1997;Markman et al 1991;Myers et al 1991) and animal studies (e.g., Campbell et al 1999Campbell et al , 2003bChurch et al 1995;Kaltenbach et al 1997;Laurell and Bagger-Sjoback 1991;Marco-Algarra et al 1985;Nakai et al 1982;Otto et al 1988;Schweitzer 1993;Schweitzer et al 1986). …”

Section: Discussionsupporting

confidence: 79%

“…For example, otoprotection has been observed for sodium thiosulfate (Church et al 1995;Otto et al 1988), diethyldithiocarbamate (Church et al 1995;Rybak et al 1995), glutathione (Campbell et al 1996(Campbell et al , 2003a, and D-methionine (Campbell et al 1999(Campbell et al , 2003b. To the best of our knowledge, there are only two previously published studies with proper scientific control groups that investigated WR's chemoprotective effects against CIS-induced ototoxicity (Church et al 1995;Kaltenbach et al 1997).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

WR-2721 (Amifostine) Ameliorates Cisplatin-Induced Hearing Loss But Causes Neurotoxicity In Hamsters: Dose-Dependent Effects

Church

Blakley

Burgio

et al. 2004

JARO

View full text Add to dashboard Cite

Chemoprotective agents reduce the toxic side effects of chemotherapy agents such as cisplatin. The conventional belief is that the chemoprotective agent WR-2721 (Amifostine), while protecting against most cisplatin-induced side effects, does not protect against cisplatin-induced ototoxicity (i.e., hearing loss). There is no knowledge, however, about the efficacy of high doses of WR-2721 (WR) in possibly protecting against cisplatin-induced ototoxicity. Thus, the dose-dependent effects of WR in possibly ameliorating cisplatin-induced ototoxicity were investigated. Hamsters were given a series of 5 cisplatin injections (3 mg/kg/injection once every other day, i.p.) either alone or in combination with 18, 40, 80, or 400 mg/kg/injection of the rescue agent WR (n = 5 or 10/group). Other groups received either 80 mg/kg/injection WR alone (n = 5) or were untreated (n = 14). Ototoxicity was assessed by auditory brain stem responses (ABR). WR provided dose-dependent rescue from cisplatin's ototoxicity with no protection at the low dose of 18 mg/ kg, moderate protection at 40 mg/kg, and nearly complete protection at 80 and 400 mg/kg. However, WR doses of 40 mg/kg or higher caused neurotoxicity as evidenced by prolongations in the ABR's interpeak latencies. Thus, high doses of WR provided the beneficial effect of protecting against cisplatininduced ototoxicity, but had the harmful side effect of neurotoxicity. Previous failures to find chemoprotection from cisplatin-induced ototoxicity were likely due to the use of WR doses that were too small. The clinical implications of the beneficial and harmful effects of high doses of WR are discussed.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

WR-2721 (Amifostine) Ameliorates Cisplatin-Induced Hearing Loss But Causes Neurotoxicity In Hamsters: Dose-Dependent Effects

Church

Blakley

Burgio

et al. 2004

JARO

View full text Add to dashboard Cite

show abstract

“…Sodium thiosul-fate protects against carboplatin ototoxicity in both humans and animals [Neuwelt et al, 1996[Neuwelt et al, , 1998Otto et al, 1988]. In addition, 4-methylthiobenzoic acid and diethylthiocarbamate not only protect against cisplatin ototoxicity in rats, but do so by maintaining the integrity of cellular antioxidant defense systems.…”

Section: Discussionmentioning

confidence: 99%

“…Sodium thiosulfate has been shown to protect against carboplatin ototoxicity in both animal and human studies [Neuwelt et al, 1996[Neuwelt et al, , 1998Otto et al, 1988]. Similarly, D-methionine (D-Met) has been shown to protect rats from the ototoxic effects of cisplatin [Campbell et al, 1996].…”

Section: Introductionmentioning

confidence: 99%

<i>D</i>-Methionine Attenuates Inner Hair Cell Loss in Carboplatin-Treated Chinchillas

Lockwood¹,

Ding²,

Wang³

et al. 2000

Audiol Neurotol

View full text Add to dashboard Cite

Carboplatin, a second-generation platinum-based antineoplastic drug, preferentially destroys inner hair cells (IHCs) in the chinchilla while sparing outer hair cells (OHCs). D-Methionine (D-Met), a sulfur-containing amino acid, has been shown to protect hair cells from cisplatin damage in rats, but its ability to protect IHCs from carboplatin damage has not yet been evaluated in the chinchilla. We tested whether D-Met would protect the hair cells in the chinchilla from carboplatin. Animals were divided into two groups: a control group that only received carboplatin (100 mg/kg, i.p.) and an experimental group that received 300 mg/kg D-Met (i.p.) 30 min before carboplatin treatment. Ototoxicity was assessed by measuring the amount of IHC and OHC loss. Average IHC loss in the group treated with D-Met was 62% compared with 84% in the untreated control group. Thus, D-Met causes a statistically significant reduction in IHC loss induced by carboplatin.

show abstract

“…Sulfur containing compounds such as sodium thiosulfate (STS) and diethyl-dithiocarbamate (DDTC) were reported to provide good otoprotection against cisplatin (Otto et al, 1988), but had significant side effects and/or interference with antitumor activity (Jones et al, 1991;Church et al, 1995;Gandara et al, 1995;Muldoon et al, 2000). D-Methionine (D-Met), also a sulfur-containing nucleophilic antioxidant, has shown to provide effective nephroprotection against cisplatin without interfering with antitumor action (Jones and Basinger, 1989).…”

Section: Introductionmentioning

confidence: 99%

d-Methionine protects against cisplatin-induced neurotoxicity in cortical networks

Gopal

Shrestha

et al. 2012

Neurotoxicology and Teratology

View full text Add to dashboard Cite

Cisplatin is a platinum-based chemotherapeutic agent widely used for the treatment of various types of cancer. Patients undergoing cisplatin treatment often suffer from a condition known as "chemobrain", ototoxicity, peripheral neuropathy, weight loss, nausea, vomiting, nephrotoxicity, seizures, hearing loss and tinnitus.D-Methionine (D-Met), a sulfur-containing nucleophilic antioxidant, has been shown to prevent cisplatininduced side effects in animals without antitumor interference. In this study, we have used an in vitro model of cortical networks (CNs), enriched in auditory cortex cells; to quantify cisplatin neurotoxicity and the protective effects of D-Met. Dissociated neurons from auditory cortices of mouse embryos were grown on microelectrode arrays with 64 transparent indium-tin oxide electrodes, which enabled continuous optical and electrophysiological monitoring of network neurons. Cisplatin at 0.10-0.25 mM induced up to a 200% increase in spontaneous spiking activity, while concentrations at or above 0.5 mM caused irreversible loss of neuronal activity, accompanied by cell death. Pretreatment with D-Met, at a concentration of 1.0 mM, prevented the cisplatin-induced excitation at 0.10-0.25 mM, caused sustained excitation without occurrence of cell death at 0.5 mM, and delayed cell death at 0.75 mM cisplatin. L-Methionine, the optical isomer, showed lower potency and less efficacy than D-Met, was less protective against 0.1 mM cisplatin, and proved ineffective at a concentration of 0.5 mM cisplatin. Pre-exposure time of D-Met was associated with the protective effects at 0.1 and 0.5 mM cisplatin, with longer pre-exposure times exhibiting better protection. This study quantifies as a function of concentration and time that D-Met protects central nervous system tissue from acute cisplatin toxicity.

show abstract

Effects of cisplatin and thiosulfate upon auditory brainstem responses of guinea pigs

Cited by 78 publications

References 10 publications

WR-2721 (Amifostine) Ameliorates Cisplatin-Induced Hearing Loss But Causes Neurotoxicity In Hamsters: Dose-Dependent Effects

WR-2721 (Amifostine) Ameliorates Cisplatin-Induced Hearing Loss But Causes Neurotoxicity In Hamsters: Dose-Dependent Effects

<i>D</i>-Methionine Attenuates Inner Hair Cell Loss in Carboplatin-Treated Chinchillas

d-Methionine protects against cisplatin-induced neurotoxicity in cortical networks

Contact Info

Product

Resources

About